7C41

KRAS G12V and H-REV107 peptide complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding
G	0007165	biological_process	signal transduction
G	0016020	cellular_component	membrane
J	0003924	molecular_function	GTPase activity
J	0005525	molecular_function	GTP binding
J	0007165	biological_process	signal transduction
J	0016020	cellular_component	membrane
M	0003924	molecular_function	GTPase activity
M	0005525	molecular_function	GTP binding
M	0007165	biological_process	signal transduction
M	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue GDP A 201

Chain	Residue
A	GLY13
A	ASN116
A	LYS117
A	ASP119
A	LEU120
A	SER145
A	ALA146
A	LYS147
A	MG202
A	HOH301
A	HOH307
A	VAL14
D	TYR66
D	GLY70
D	SER71
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	VAL29
A	ASP30

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 202

Chain	Residue
A	LYS16
A	SER17
A	ASP57
A	THR58
A	GDP201
D	TYR66

---

site_id	AC3
Number of Residues	18
Details	binding site for residue GDP J 201

Chain	Residue
J	GLY13
J	VAL14
J	GLY15
J	LYS16
J	SER17
J	ALA18
J	PHE28
J	ASP30
J	TYR32
J	ASN116
J	LYS117
J	ASP119
J	LEU120
J	SER145
J	ALA146
J	LYS147
J	MG202
J	HOH305

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG J 202

Chain	Residue
J	PRO34
J	GDP201

---

site_id	AC5
Number of Residues	18
Details	binding site for residue GDP M 201

Chain	Residue
M	ALA11
M	GLY13
M	VAL14
M	GLY15
M	LYS16
M	SER17
M	ALA18
M	PHE28
M	ASP30
M	TYR32
M	ASN116
M	LYS117
M	ASP119
M	SER145
M	ALA146
M	LYS147
M	MG202
M	HOH307

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG M 202

Chain	Residue
M	SER17
M	PRO34
M	GDP201
M	HOH321

---

site_id	AC7
Number of Residues	20
Details	binding site for residue GDP G 201

Chain	Residue
G	VAL12
G	GLY13
G	VAL14
G	GLY15
G	LYS16
G	SER17
G	ALA18
G	PHE28
G	VAL29
G	ASP30
G	TYR32
G	ASN116
G	LYS117
G	ASP119
G	LEU120
G	SER145
G	ALA146
G	HOH305
G	HOH307
G	HOH309

---

site_id	AC8
Number of Residues	5
Details	binding site for residue MG G 202

Chain	Residue
G	SER17
G	TYR32
G	ASP33
G	PRO34
G	ILE36

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140

Chain	Residue	Details
A	GLY10
M	VAL29
M	ALA59
M	ASN116
G	GLY10
G	VAL29
G	ALA59
G	ASN116
A	VAL29
A	ALA59
A	ASN116
J	GLY10
J	VAL29
J	ALA59
J	ASN116
M	GLY10

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17

Chain	Residue	Details
A	MET1
J	MET1
M	MET1
G	MET1

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17

Chain	Residue	Details
A	THR2
J	THR2
M	THR2
G	THR2

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838

Chain	Residue	Details
A	LYS104
J	LYS104
M	LYS104
G	LYS104

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486

Chain	Residue	Details
A	THR35
J	THR35
M	THR35
G	THR35

---