7C41
KRAS G12V and H-REV107 peptide complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| G | 0003924 | molecular_function | GTPase activity |
| G | 0005525 | molecular_function | GTP binding |
| G | 0007165 | biological_process | signal transduction |
| G | 0016020 | cellular_component | membrane |
| J | 0003924 | molecular_function | GTPase activity |
| J | 0005525 | molecular_function | GTP binding |
| J | 0007165 | biological_process | signal transduction |
| J | 0016020 | cellular_component | membrane |
| M | 0003924 | molecular_function | GTPase activity |
| M | 0005525 | molecular_function | GTP binding |
| M | 0007165 | biological_process | signal transduction |
| M | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue GDP A 201 |
| Chain | Residue |
| A | GLY13 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG202 |
| A | HOH301 |
| A | HOH307 |
| A | VAL14 |
| D | TYR66 |
| D | GLY70 |
| D | SER71 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| A | ASP30 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | LYS16 |
| A | SER17 |
| A | ASP57 |
| A | THR58 |
| A | GDP201 |
| D | TYR66 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue GDP J 201 |
| Chain | Residue |
| J | GLY13 |
| J | VAL14 |
| J | GLY15 |
| J | LYS16 |
| J | SER17 |
| J | ALA18 |
| J | PHE28 |
| J | ASP30 |
| J | TYR32 |
| J | ASN116 |
| J | LYS117 |
| J | ASP119 |
| J | LEU120 |
| J | SER145 |
| J | ALA146 |
| J | LYS147 |
| J | MG202 |
| J | HOH305 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MG J 202 |
| Chain | Residue |
| J | PRO34 |
| J | GDP201 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue GDP M 201 |
| Chain | Residue |
| M | ALA11 |
| M | GLY13 |
| M | VAL14 |
| M | GLY15 |
| M | LYS16 |
| M | SER17 |
| M | ALA18 |
| M | PHE28 |
| M | ASP30 |
| M | TYR32 |
| M | ASN116 |
| M | LYS117 |
| M | ASP119 |
| M | SER145 |
| M | ALA146 |
| M | LYS147 |
| M | MG202 |
| M | HOH307 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG M 202 |
| Chain | Residue |
| M | SER17 |
| M | PRO34 |
| M | GDP201 |
| M | HOH321 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | binding site for residue GDP G 201 |
| Chain | Residue |
| G | VAL12 |
| G | GLY13 |
| G | VAL14 |
| G | GLY15 |
| G | LYS16 |
| G | SER17 |
| G | ALA18 |
| G | PHE28 |
| G | VAL29 |
| G | ASP30 |
| G | TYR32 |
| G | ASN116 |
| G | LYS117 |
| G | ASP119 |
| G | LEU120 |
| G | SER145 |
| G | ALA146 |
| G | HOH305 |
| G | HOH307 |
| G | HOH309 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MG G 202 |
| Chain | Residue |
| G | SER17 |
| G | TYR32 |
| G | ASP33 |
| G | PRO34 |
| G | ILE36 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 72 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
