7BV5

Crystal structure of the yeast heterodimeric ADAT2/3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002100	biological_process	tRNA wobble adenosine to inosine editing
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006400	biological_process	tRNA modification
A	0008033	biological_process	tRNA processing
A	0008251	molecular_function	tRNA-specific adenosine deaminase activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0052717	molecular_function	tRNA-specific adenosine-34 deaminase activity
A	0052718	cellular_component	tRNA-specific adenosine-34 deaminase complex
B	0002100	biological_process	tRNA wobble adenosine to inosine editing
B	0003824	molecular_function	catalytic activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006400	biological_process	tRNA modification
B	0008033	biological_process	tRNA processing
B	0008251	molecular_function	tRNA-specific adenosine deaminase activity
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0052717	molecular_function	tRNA-specific adenosine-34 deaminase activity
B	0052718	cellular_component	tRNA-specific adenosine-34 deaminase complex
C	0002100	biological_process	tRNA wobble adenosine to inosine editing
C	0003824	molecular_function	catalytic activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005777	cellular_component	peroxisome
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006400	biological_process	tRNA modification
C	0008033	biological_process	tRNA processing
C	0008251	molecular_function	tRNA-specific adenosine deaminase activity
C	0008270	molecular_function	zinc ion binding
C	0016814	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
C	0019239	molecular_function	deaminase activity
C	0052718	cellular_component	tRNA-specific adenosine-34 deaminase complex
D	0002100	biological_process	tRNA wobble adenosine to inosine editing
D	0003824	molecular_function	catalytic activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005777	cellular_component	peroxisome
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006400	biological_process	tRNA modification
D	0008033	biological_process	tRNA processing
D	0008251	molecular_function	tRNA-specific adenosine deaminase activity
D	0008270	molecular_function	zinc ion binding
D	0016814	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
D	0019239	molecular_function	deaminase activity
D	0052718	cellular_component	tRNA-specific adenosine-34 deaminase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS54
A	CYS88
A	CYS91
A	HOH416

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS54
B	CYS88
B	CYS91
B	HOH412

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 401

Chain	Residue
C	CYS254
C	CYS257
C	CYS322
C	HIS216

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN D 401

Chain	Residue
D	HIS216
D	CYS254
D	CYS257
D	CYS322

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Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGdDYRTCFA

Chain	Residue	Details
A	PHE198-ALA207

---

site_id	PS00903
Number of Residues	42
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEfmGIdqikamlgsrgvvdvfkditlyvtve.......PCim......CasaL

Chain	Residue	Details
A	HIS54-LEU95

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	478
Details	Domain: {"description":"CMP/dCMP-type deaminase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33272269","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7BV5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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