7BQ0

X-ray structure of human PPARalpha ligand binding domain-fenofibric acid-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue F5A A 501

Chain	Residue
A	PHE273
A	ALA454
A	ALA455
A	LEU456
A	TYR464
A	CYS276
A	GLN277
A	SER280
A	TYR314
A	HIS440
A	VAL444
A	ILE447
A	LYS448

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site_id	AC2
Number of Residues	8
Details	binding site for residue F5A A 502

Chain	Residue
A	LEU247
A	LEU254
A	LYS257
A	CYS275
A	THR279
A	ALA333
A	TYR334
A	HOH680

---

site_id	AC3
Number of Residues	12
Details	binding site for residue F5A C 501

Chain	Residue
C	PHE273
C	GLN277
C	SER280
C	TYR314
C	HIS440
C	VAL444
C	ILE447
C	LYS448
C	ALA454
C	ALA455
C	LEU456
C	TYR464

---

site_id	AC4
Number of Residues	9
Details	binding site for residue F5A C 502

Chain	Residue
C	LEU247
C	LYS257
C	CYS275
C	THR279
C	GLU282
C	ALA333
C	TYR334
C	HOH613
C	HOH618

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1

Chain	Residue	Details
A	SER280
A	TYR314
A	TYR464
C	SER280
C	TYR314
C	TYR464

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Essential for heterodimerization with RXRA

Chain	Residue	Details
A	LEU433
C	LEU433

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