7BJU
Crystal structure of the ligand-binding domains of the heterodimer EcR/USP bound to the synthetic agonist BYI08346
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004879 | molecular_function | nuclear receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0035076 | biological_process | ecdysone receptor signaling pathway |
| D | 0035100 | molecular_function | ecdysone binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue EPH A 501 |
| Chain | Residue |
| A | LEU230 |
| A | LEU435 |
| A | PHE438 |
| A | PRO239 |
| A | PHE242 |
| A | LEU249 |
| A | GLY328 |
| A | SER335 |
| A | GLN338 |
| A | ALA339 |
| A | HIS434 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue PEG D 601 |
| Chain | Residue |
| A | LYS355 |
| D | ASP448 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue 834 D 602 |
| Chain | Residue |
| D | THR343 |
| D | MET380 |
| D | MET381 |
| D | VAL384 |
| D | TYR403 |
| D | TYR408 |
| D | VAL416 |
| D | ASP419 |
| D | LEU420 |
| D | GLN503 |
| D | ASN504 |
| D | MET507 |
| D | CYS508 |
| D | LEU522 |
| D | TRP526 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PE8 D 603 |
| Chain | Residue |
| D | SER296 |
| D | SER296 |
| D | ALA299 |
| D | ARG300 |
| D | TYR303 |
| D | TYR303 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue PGE D 604 |
| Chain | Residue |
| D | LYS362 |
| D | TYR464 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue MG D 605 |
| Chain | Residue |
| D | PHE353 |
| D | GLY356 |
