7BI2

PI3KC2aDeltaN and DeltaC-C2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016301	molecular_function	kinase activity
A	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
A	0035091	molecular_function	phosphatidylinositol binding
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue EDO A 1201

Chain	Residue
A	LEU18
A	LYS21

---

site_id	AC2
Number of Residues	12
Details	binding site for residue 17G A 1202

Chain	Residue
A	VAL805
A	SER808
A	THR810
A	MET875
A	ILE885
A	PHE730
A	SER732
A	PRO736
A	MET754
A	LYS756
A	VAL802
A	LEU804

---

site_id	AC3
Number of Residues	2
Details	binding site for residue IOD A 1203

Chain	Residue
A	THR307
A	ASP457

---

site_id	AC4
Number of Residues	1
Details	binding site for residue IOD A 1204

Chain	Residue
A	LEU804

---

site_id	AC5
Number of Residues	3
Details	binding site for residue IOD A 1205

Chain	Residue
A	GLU56
A	ILE57
A	LEU60

---

site_id	AC6
Number of Residues	2
Details	binding site for residue IOD A 1206

Chain	Residue
A	HIS523
A	ASN525

---

site_id	AC7
Number of Residues	2
Details	binding site for residue IOD A 1207

Chain	Residue
A	GLN305
A	PRO459

---

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKvg.EDLRQDmlalQ

Chain	Residue	Details
A	PHE755-GLN769

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgccVatYVLgIcDRHndN

Chain	Residue	Details
A	SER853-ASN873

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O00443","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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