7BBF

Crystal structure of ubiquitin charged Ube2N (Ube2N~Ub) in complex with Ube2V2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000151	cellular_component	ubiquitin ligase complex
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000729	biological_process	DNA double-strand break processing
A	0003723	molecular_function	RNA binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006282	biological_process	regulation of DNA repair
A	0006301	biological_process	DNA damage tolerance
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0006974	biological_process	DNA damage response
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0031371	cellular_component	ubiquitin conjugating enzyme complex
A	0031372	cellular_component	UBC13-MMS2 complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032991	cellular_component	protein-containing complex
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043130	molecular_function	ubiquitin binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045739	biological_process	positive regulation of DNA repair
A	0050852	biological_process	T cell receptor signaling pathway
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070062	cellular_component	extracellular exosome
A	0070534	biological_process	protein K63-linked ubiquitination
A	0097027	molecular_function	ubiquitin-protein transferase activator activity
A	0140374	biological_process	antiviral innate immune response
A	1902523	biological_process	positive regulation of protein K63-linked ubiquitination
A	1902533	biological_process	positive regulation of intracellular signal transduction
A	1904262	biological_process	negative regulation of TORC1 signaling
A	2000781	biological_process	positive regulation of double-strand break repair
B	0000209	biological_process	protein polyubiquitination
B	0000729	biological_process	DNA double-strand break processing
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006282	biological_process	regulation of DNA repair
B	0006301	biological_process	DNA damage tolerance
B	0016567	biological_process	protein ubiquitination
B	0031371	cellular_component	ubiquitin conjugating enzyme complex
B	0031372	cellular_component	UBC13-MMS2 complex
B	0042275	biological_process	error-free postreplication DNA repair
B	0070062	cellular_component	extracellular exosome
B	0070534	biological_process	protein K63-linked ubiquitination
B	1902523	biological_process	positive regulation of protein K63-linked ubiquitination
B	2000781	biological_process	positive regulation of double-strand break repair
D	0000151	cellular_component	ubiquitin ligase complex
D	0000166	molecular_function	nucleotide binding
D	0000209	biological_process	protein polyubiquitination
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000729	biological_process	DNA double-strand break processing
D	0003723	molecular_function	RNA binding
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006282	biological_process	regulation of DNA repair
D	0006301	biological_process	DNA damage tolerance
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006974	biological_process	DNA damage response
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0031371	cellular_component	ubiquitin conjugating enzyme complex
D	0031372	cellular_component	UBC13-MMS2 complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032991	cellular_component	protein-containing complex
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043130	molecular_function	ubiquitin binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0045739	biological_process	positive regulation of DNA repair
D	0050852	biological_process	T cell receptor signaling pathway
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0061631	molecular_function	ubiquitin conjugating enzyme activity
D	0070062	cellular_component	extracellular exosome
D	0070534	biological_process	protein K63-linked ubiquitination
D	0097027	molecular_function	ubiquitin-protein transferase activator activity
D	0140374	biological_process	antiviral innate immune response
D	1902523	biological_process	positive regulation of protein K63-linked ubiquitination
D	1902533	biological_process	positive regulation of intracellular signal transduction
D	1904262	biological_process	negative regulation of TORC1 signaling
D	2000781	biological_process	positive regulation of double-strand break repair
E	0000209	biological_process	protein polyubiquitination
E	0000729	biological_process	DNA double-strand break processing
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0006282	biological_process	regulation of DNA repair
E	0006301	biological_process	DNA damage tolerance
E	0016567	biological_process	protein ubiquitination
E	0031371	cellular_component	ubiquitin conjugating enzyme complex
E	0031372	cellular_component	UBC13-MMS2 complex
E	0042275	biological_process	error-free postreplication DNA repair
E	0070062	cellular_component	extracellular exosome
E	0070534	biological_process	protein K63-linked ubiquitination
E	1902523	biological_process	positive regulation of protein K63-linked ubiquitination
E	2000781	biological_process	positive regulation of double-strand break repair
G	0000151	cellular_component	ubiquitin ligase complex
G	0000166	molecular_function	nucleotide binding
G	0000209	biological_process	protein polyubiquitination
G	0000724	biological_process	double-strand break repair via homologous recombination
G	0000729	biological_process	DNA double-strand break processing
G	0003723	molecular_function	RNA binding
G	0004842	molecular_function	ubiquitin-protein transferase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006281	biological_process	DNA repair
G	0006282	biological_process	regulation of DNA repair
G	0006301	biological_process	DNA damage tolerance
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006513	biological_process	protein monoubiquitination
G	0006974	biological_process	DNA damage response
G	0016567	biological_process	protein ubiquitination
G	0016740	molecular_function	transferase activity
G	0031371	cellular_component	ubiquitin conjugating enzyme complex
G	0031372	cellular_component	UBC13-MMS2 complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032991	cellular_component	protein-containing complex
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043130	molecular_function	ubiquitin binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0045739	biological_process	positive regulation of DNA repair
G	0050852	biological_process	T cell receptor signaling pathway
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0061631	molecular_function	ubiquitin conjugating enzyme activity
G	0070062	cellular_component	extracellular exosome
G	0070534	biological_process	protein K63-linked ubiquitination
G	0097027	molecular_function	ubiquitin-protein transferase activator activity
G	0140374	biological_process	antiviral innate immune response
G	1902523	biological_process	positive regulation of protein K63-linked ubiquitination
G	1902533	biological_process	positive regulation of intracellular signal transduction
G	1904262	biological_process	negative regulation of TORC1 signaling
G	2000781	biological_process	positive regulation of double-strand break repair
H	0000209	biological_process	protein polyubiquitination
H	0000729	biological_process	DNA double-strand break processing
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0006282	biological_process	regulation of DNA repair
H	0006301	biological_process	DNA damage tolerance
H	0016567	biological_process	protein ubiquitination
H	0031371	cellular_component	ubiquitin conjugating enzyme complex
H	0031372	cellular_component	UBC13-MMS2 complex
H	0042275	biological_process	error-free postreplication DNA repair
H	0070062	cellular_component	extracellular exosome
H	0070534	biological_process	protein K63-linked ubiquitination
H	1902523	biological_process	positive regulation of protein K63-linked ubiquitination
H	2000781	biological_process	positive regulation of double-strand break repair

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
I	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	697
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"PubMed","id":"16112642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16122702","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	75
Details	Domain: {"description":"Ubiquitin-like 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---