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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7B75

Cryo-EM Structure of Human Thyroglobulin

Functional Information from PROSITE/UniProt
site_idPS00484
Number of Residues31
DetailsTHYROGLOBULIN_1_1 Thyroglobulin type-1 repeat signature. YvpqCaed.GsFqtvQcqndgrsc....WCVgangS
ChainResidueDetails
ATYR48-SER78
ATYR116-GLY145
ATYR315-GLY343
APHE616-GLY643
APHE683-GLY710
ATYR1027-GLY1057
APHE1104-GLY1132
ATYR1165-GLY1195
AALA1519-GLY1548
site_idPS00941
Number of Residues11
DetailsCARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNVFiP
ChainResidueDetails
AGLU2279-PRO2289
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues122
DetailsDomain: {"description":"Thyroglobulin type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00500","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues272
DetailsDomain: {"description":"Thyroglobulin type-1 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00500","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues120
DetailsDomain: {"description":"Thyroglobulin type-1 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00500","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues106
DetailsDomain: {"description":"Thyroglobulin type-1 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00500","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues134
DetailsDomain: {"description":"Thyroglobulin type-1 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00500","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues302
DetailsDomain: {"description":"Thyroglobulin type-1 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00500","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues142
DetailsDomain: {"description":"Thyroglobulin type-1 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00500","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues128
DetailsDomain: {"description":"Thyroglobulin type-1 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00500","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues90
DetailsRepeat: {"description":"Type II","evidences":[{"source":"PubMed","id":"8797845","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues108
DetailsDomain: {"description":"Thyroglobulin type-1 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00500","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues318
DetailsRepeat: {"description":"Type IIIA","evidences":[{"source":"PubMed","id":"8797845","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues266
DetailsRepeat: {"description":"Type IIIB","evidences":[{"source":"PubMed","id":"8797845","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsSite: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"8615697","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Iodotyrosine; alternate","evidences":[{"source":"PubMed","id":"2760035","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32025030","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsModified residue: {"description":"Iodotyrosine","evidences":[{"source":"PubMed","id":"32025030","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues10
DetailsModified residue: {"description":"Iodotyrosine","evidences":[{"source":"PubMed","id":"2760035","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsModified residue: {"description":"Triiodothyronine; alternate","evidences":[{"source":"PubMed","id":"2760035","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues6
DetailsModified residue: {"description":"Iodotyrosine; alternate","evidences":[{"source":"PubMed","id":"2760035","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsModified residue: {"description":"Diiodotyrosine","evidences":[{"source":"PubMed","id":"2760035","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"Thyroxine","evidences":[{"source":"PubMed","id":"2760035","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32025030","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues26
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32025030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8615697","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SCJ","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8615697","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8615697","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32025030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SCJ","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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