Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| B | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue IMD A 1101 |
| Chain | Residue |
| A | ARG568 |
| A | LEU569 |
| A | PRO570 |
| A | PRO651 |
| A | GLU652 |
| A | PRO653 |
| A | PHE677 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue IMD A 1102 |
| Chain | Residue |
| A | IMD1103 |
| A | S2Z1105 |
| A | HOH1225 |
| A | TYR884 |
| A | PHE890 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue IMD A 1103 |
| Chain | Residue |
| A | TYR884 |
| A | GLU902 |
| A | IMD1102 |
| A | S2Z1105 |
| A | HOH1529 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue IMD A 1104 |
| Chain | Residue |
| A | LEU872 |
| A | VAL875 |
| A | SER876 |
| A | ASN879 |
| A | SER908 |
| A | TYR912 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue S2Z A 1105 |
| Chain | Residue |
| A | ASN879 |
| A | TYR884 |
| A | PHE890 |
| A | LEU901 |
| A | GLU902 |
| A | HIS905 |
| A | GLU906 |
| A | IMD1102 |
| A | IMD1103 |
| A | HOH1515 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue IMD B 1101 |
| Chain | Residue |
| B | ARG568 |
| B | LEU569 |
| B | PRO570 |
| B | PRO651 |
| B | GLU652 |
| B | PRO653 |
| B | PHE677 |
| B | HOH1311 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue IMD B 1102 |
| Chain | Residue |
| B | TYR884 |
| B | PHE890 |
| B | IMD1103 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue IMD B 1103 |
| Chain | Residue |
| B | TYR884 |
| B | GLU902 |
| B | IMD1102 |
| B | S2Z1104 |
| B | HOH1208 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue S2Z B 1104 |
| Chain | Residue |
| B | ASN879 |
| B | TYR884 |
| B | PHE890 |
| B | GLU902 |
| B | HIS905 |
| B | GLU906 |
| B | IMD1103 |
Functional Information from PROSITE/UniProt
| site_id | PS00720 |
| Number of Residues | 34 |
| Details | RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK |
| Chain | Residue | Details |
| A | VAL927-LYS960 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 288 |
| Details | Domain: {"description":"N-terminal Ras-GEF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00135","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 478 |
| Details | Domain: {"description":"Ras-GEF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00168","evidenceCode":"ECO:0000255"}]} |
