7AK5

Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0006979	biological_process	response to oxidative stress
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0009060	biological_process	aerobic respiration
A	0009642	biological_process	response to light intensity
A	0009725	biological_process	response to hormone
A	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
A	0045271	cellular_component	respiratory chain complex I
A	0071385	biological_process	cellular response to glucocorticoid stimulus
A	1902600	biological_process	proton transmembrane transport
B	0002020	molecular_function	protease binding
B	0003954	molecular_function	NADH dehydrogenase activity
B	0004497	molecular_function	monooxygenase activity
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0009060	biological_process	aerobic respiration
B	0015990	biological_process	electron transport coupled proton transport
B	0016491	molecular_function	oxidoreductase activity
B	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
B	0043025	cellular_component	neuronal cell body
B	0045271	cellular_component	respiratory chain complex I
B	0046872	molecular_function	metal ion binding
B	0048038	molecular_function	quinone binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0097060	cellular_component	synaptic membrane
C	0003954	molecular_function	NADH dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016604	cellular_component	nuclear body
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0031966	cellular_component	mitochondrial membrane
C	0032981	biological_process	mitochondrial respiratory chain complex I assembly
C	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
C	0043209	cellular_component	myelin sheath
C	0045271	cellular_component	respiratory chain complex I
C	0072593	biological_process	reactive oxygen species metabolic process
C	1902600	biological_process	proton transmembrane transport
D	0003954	molecular_function	NADH dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0009060	biological_process	aerobic respiration
D	0016491	molecular_function	oxidoreductase activity
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0019826	molecular_function	oxygen sensor activity
D	0022008	biological_process	neurogenesis
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D	0042063	biological_process	gliogenesis
D	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045271	cellular_component	respiratory chain complex I
D	0046872	molecular_function	metal ion binding
D	0048038	molecular_function	quinone binding
D	0051287	molecular_function	NAD binding
D	0051536	molecular_function	iron-sulfur cluster binding
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0061351	biological_process	neural precursor cell proliferation
D	0071453	biological_process	cellular response to oxygen levels
D	1902600	biological_process	proton transmembrane transport
E	0003954	molecular_function	NADH dehydrogenase activity
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
E	0007399	biological_process	nervous system development
E	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
E	0009060	biological_process	aerobic respiration
E	0016491	molecular_function	oxidoreductase activity
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0043209	cellular_component	myelin sheath
E	0045271	cellular_component	respiratory chain complex I
E	0046872	molecular_function	metal ion binding
E	0048738	biological_process	cardiac muscle tissue development
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	1902600	biological_process	proton transmembrane transport
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0009060	biological_process	aerobic respiration
F	0010181	molecular_function	FMN binding
F	0016491	molecular_function	oxidoreductase activity
F	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045271	cellular_component	respiratory chain complex I
F	0046872	molecular_function	metal ion binding
F	0051287	molecular_function	NAD binding
F	0051536	molecular_function	iron-sulfur cluster binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	1902600	biological_process	proton transmembrane transport
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005758	cellular_component	mitochondrial intermembrane space
G	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0009055	molecular_function	electron transfer activity
G	0009060	biological_process	aerobic respiration
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0032981	biological_process	mitochondrial respiratory chain complex I assembly
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
G	0043209	cellular_component	myelin sheath
G	0045271	cellular_component	respiratory chain complex I
G	0045333	biological_process	cellular respiration
G	0046872	molecular_function	metal ion binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	1902600	biological_process	proton transmembrane transport
H	0001666	biological_process	response to hypoxia
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0009410	biological_process	response to xenobiotic stimulus
H	0016020	cellular_component	membrane
H	0030425	cellular_component	dendrite
H	0031966	cellular_component	mitochondrial membrane
H	0032981	biological_process	mitochondrial respiratory chain complex I assembly
H	0033194	biological_process	response to hydroperoxide
H	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
H	0043025	cellular_component	neuronal cell body
H	0045271	cellular_component	respiratory chain complex I
H	1902600	biological_process	proton transmembrane transport
I	0003954	molecular_function	NADH dehydrogenase activity
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0009060	biological_process	aerobic respiration
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0032981	biological_process	mitochondrial respiratory chain complex I assembly
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0045271	cellular_component	respiratory chain complex I
I	0046872	molecular_function	metal ion binding
I	0051536	molecular_function	iron-sulfur cluster binding
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
I	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0009060	biological_process	aerobic respiration
J	0032981	biological_process	mitochondrial respiratory chain complex I assembly
J	0035094	biological_process	response to nicotine
J	0042220	biological_process	response to cocaine
J	0042542	biological_process	response to hydrogen peroxide
J	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
J	0045271	cellular_component	respiratory chain complex I
J	1902600	biological_process	proton transmembrane transport
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0009060	biological_process	aerobic respiration
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
K	0045271	cellular_component	respiratory chain complex I
K	1902600	biological_process	proton transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0009060	biological_process	aerobic respiration
L	0015990	biological_process	electron transport coupled proton transport
L	0032981	biological_process	mitochondrial respiratory chain complex I assembly
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
L	0045271	cellular_component	respiratory chain complex I
M	0001666	biological_process	response to hypoxia
M	0001701	biological_process	in utero embryonic development
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0015990	biological_process	electron transport coupled proton transport
M	0021549	biological_process	cerebellum development
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0035094	biological_process	response to nicotine
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
M	0045271	cellular_component	respiratory chain complex I
M	0045471	biological_process	response to ethanol
M	0048039	molecular_function	ubiquinone binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009060	biological_process	aerobic respiration
N	0019901	molecular_function	protein kinase binding
N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N	0035255	molecular_function	ionotropic glutamate receptor binding
N	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
N	0045271	cellular_component	respiratory chain complex I
N	0072593	biological_process	reactive oxygen species metabolic process
N	1902600	biological_process	proton transmembrane transport
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005759	cellular_component	mitochondrial matrix
O	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
O	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
O	0009060	biological_process	aerobic respiration
O	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
O	0043209	cellular_component	myelin sheath
O	0045271	cellular_component	respiratory chain complex I
O	1902600	biological_process	proton transmembrane transport
P	0003954	molecular_function	NADH dehydrogenase activity
P	0005515	molecular_function	protein binding
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005759	cellular_component	mitochondrial matrix
P	0006744	biological_process	ubiquinone biosynthetic process
P	0007623	biological_process	circadian rhythm
P	0009060	biological_process	aerobic respiration
P	0031966	cellular_component	mitochondrial membrane
P	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
P	0044877	molecular_function	protein-containing complex binding
P	0045271	cellular_component	respiratory chain complex I
Q	0003016	biological_process	respiratory system process
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0006099	biological_process	tricarboxylic acid cycle
Q	0006954	biological_process	inflammatory response
Q	0007420	biological_process	brain development
Q	0007601	biological_process	visual perception
Q	0007605	biological_process	sensory perception of sound
Q	0007628	biological_process	adult walking behavior
Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Q	0009060	biological_process	aerobic respiration
Q	0014876	biological_process	response to injury involved in regulation of muscle adaptation
Q	0022900	biological_process	electron transport chain
Q	0022904	biological_process	respiratory electron transport chain
Q	0030534	biological_process	adult behavior
Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Q	0036343	biological_process	psychomotor behavior
Q	0042417	biological_process	dopamine metabolic process
Q	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Q	0045087	biological_process	innate immune response
Q	0045271	cellular_component	respiratory chain complex I
Q	0048666	biological_process	neuron development
Q	0050890	biological_process	cognition
Q	0051402	biological_process	neuron apoptotic process
Q	0051591	biological_process	response to cAMP
Q	0051881	biological_process	regulation of mitochondrial membrane potential
Q	0071453	biological_process	cellular response to oxygen levels
Q	0072593	biological_process	reactive oxygen species metabolic process
Q	1902600	biological_process	proton transmembrane transport
R	0001822	biological_process	kidney development
R	0003674	molecular_function	molecular_function
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
R	0006631	biological_process	fatty acid metabolic process
R	0006936	biological_process	muscle contraction
R	0007005	biological_process	mitochondrion organization
R	0009060	biological_process	aerobic respiration
R	0010467	biological_process	gene expression
R	0017145	biological_process	stem cell division
R	0022904	biological_process	respiratory electron transport chain
R	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
R	0032981	biological_process	mitochondrial respiratory chain complex I assembly
R	0035264	biological_process	multicellular organism growth
R	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
R	0045271	cellular_component	respiratory chain complex I
R	0051881	biological_process	regulation of mitochondrial membrane potential
R	0061458	biological_process	reproductive system development
R	0072359	biological_process	circulatory system development
R	0072497	biological_process	mesenchymal stem cell differentiation
R	0072593	biological_process	reactive oxygen species metabolic process
R	0090398	biological_process	cellular senescence
R	0097168	biological_process	mesenchymal stem cell proliferation
S	0001835	biological_process	blastocyst hatching
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S	0009060	biological_process	aerobic respiration
S	0031966	cellular_component	mitochondrial membrane
S	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
S	0045271	cellular_component	respiratory chain complex I
S	1902600	biological_process	proton transmembrane transport
T	0000035	molecular_function	acyl binding
T	0000036	molecular_function	acyl carrier activity
T	0005198	molecular_function	structural molecule activity
T	0005654	cellular_component	nucleoplasm
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0006629	biological_process	lipid metabolic process
T	0006631	biological_process	fatty acid metabolic process
T	0006633	biological_process	fatty acid biosynthetic process
T	0009060	biological_process	aerobic respiration
T	0009249	biological_process	protein lipoylation
T	0016226	biological_process	iron-sulfur cluster assembly
T	0031966	cellular_component	mitochondrial membrane
T	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
T	0044571	biological_process	[2Fe-2S] cluster assembly
T	0045271	cellular_component	respiratory chain complex I
T	0099128	cellular_component	mitochondrial [2Fe-2S] assembly complex
T	0140978	molecular_function	mitochondrial large ribosomal subunit binding
T	1990229	cellular_component	iron-sulfur cluster assembly complex
U	0000035	molecular_function	acyl binding
U	0000036	molecular_function	acyl carrier activity
U	0005198	molecular_function	structural molecule activity
U	0005654	cellular_component	nucleoplasm
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006629	biological_process	lipid metabolic process
U	0006631	biological_process	fatty acid metabolic process
U	0006633	biological_process	fatty acid biosynthetic process
U	0009060	biological_process	aerobic respiration
U	0009249	biological_process	protein lipoylation
U	0016226	biological_process	iron-sulfur cluster assembly
U	0031966	cellular_component	mitochondrial membrane
U	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
U	0044571	biological_process	[2Fe-2S] cluster assembly
U	0045271	cellular_component	respiratory chain complex I
U	0099128	cellular_component	mitochondrial [2Fe-2S] assembly complex
U	0140978	molecular_function	mitochondrial large ribosomal subunit binding
U	1990229	cellular_component	iron-sulfur cluster assembly complex
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0009060	biological_process	aerobic respiration
V	0022904	biological_process	respiratory electron transport chain
V	0032991	cellular_component	protein-containing complex
V	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
V	0045271	cellular_component	respiratory chain complex I
W	0003674	molecular_function	molecular_function
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0009060	biological_process	aerobic respiration
W	0031966	cellular_component	mitochondrial membrane
W	0032981	biological_process	mitochondrial respiratory chain complex I assembly
W	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
W	0045271	cellular_component	respiratory chain complex I
X	0005739	cellular_component	mitochondrion
X	0005743	cellular_component	mitochondrial inner membrane
X	0005758	cellular_component	mitochondrial intermembrane space
X	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
X	0009060	biological_process	aerobic respiration
X	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
X	0044877	molecular_function	protein-containing complex binding
X	0045271	cellular_component	respiratory chain complex I
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Y	0045271	cellular_component	respiratory chain complex I
Z	0005524	molecular_function	ATP binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005739	cellular_component	mitochondrion
Z	0005743	cellular_component	mitochondrial inner membrane
Z	0006915	biological_process	apoptotic process
Z	0009060	biological_process	aerobic respiration
Z	0031966	cellular_component	mitochondrial membrane
Z	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Z	0035458	biological_process	cellular response to interferon-beta
Z	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Z	0045039	biological_process	protein insertion into mitochondrial inner membrane
Z	0045202	cellular_component	synapse
Z	0045271	cellular_component	respiratory chain complex I
Z	0045732	biological_process	positive regulation of protein catabolic process
Z	0045892	biological_process	negative regulation of DNA-templated transcription
Z	0071300	biological_process	cellular response to retinoic acid
Z	0097191	biological_process	extrinsic apoptotic signaling pathway
Z	0098803	cellular_component	respiratory chain complex
Z	1900119	biological_process	positive regulation of execution phase of apoptosis
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0009060	biological_process	aerobic respiration
a	0031966	cellular_component	mitochondrial membrane
a	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
a	0045271	cellular_component	respiratory chain complex I
b	0003674	molecular_function	molecular_function
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0009060	biological_process	aerobic respiration
b	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
b	0045271	cellular_component	respiratory chain complex I
c	0003674	molecular_function	molecular_function
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0009060	biological_process	aerobic respiration
c	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
c	0045271	cellular_component	respiratory chain complex I
d	0005737	cellular_component	cytoplasm
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0009060	biological_process	aerobic respiration
d	0010918	biological_process	positive regulation of mitochondrial membrane potential
d	0032981	biological_process	mitochondrial respiratory chain complex I assembly
d	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
d	0045271	cellular_component	respiratory chain complex I
d	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
d	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
d	2001171	biological_process	positive regulation of ATP biosynthetic process
e	0003674	molecular_function	molecular_function
e	0005739	cellular_component	mitochondrion
e	0005743	cellular_component	mitochondrial inner membrane
e	0005758	cellular_component	mitochondrial intermembrane space
e	0009060	biological_process	aerobic respiration
e	0032981	biological_process	mitochondrial respiratory chain complex I assembly
e	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
e	0045271	cellular_component	respiratory chain complex I
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0009060	biological_process	aerobic respiration
f	0016607	cellular_component	nuclear speck
f	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
f	0045271	cellular_component	respiratory chain complex I
g	0003674	molecular_function	molecular_function
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0009060	biological_process	aerobic respiration
g	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
g	0045271	cellular_component	respiratory chain complex I
h	0003674	molecular_function	molecular_function
h	0005654	cellular_component	nucleoplasm
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0009060	biological_process	aerobic respiration
h	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
h	0045271	cellular_component	respiratory chain complex I
i	0005654	cellular_component	nucleoplasm
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0009060	biological_process	aerobic respiration
i	0031966	cellular_component	mitochondrial membrane
i	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
i	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
i	0045271	cellular_component	respiratory chain complex I
j	0003674	molecular_function	molecular_function
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0009060	biological_process	aerobic respiration
j	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
j	0045271	cellular_component	respiratory chain complex I
k	0003674	molecular_function	molecular_function
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0009060	biological_process	aerobic respiration
k	0022900	biological_process	electron transport chain
k	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
k	0045271	cellular_component	respiratory chain complex I
l	0003674	molecular_function	molecular_function
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0009060	biological_process	aerobic respiration
l	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
l	0045271	cellular_component	respiratory chain complex I
m	0003674	molecular_function	molecular_function
m	0005654	cellular_component	nucleoplasm
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0009060	biological_process	aerobic respiration
m	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
m	0045271	cellular_component	respiratory chain complex I
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0009060	biological_process	aerobic respiration
n	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
n	0045271	cellular_component	respiratory chain complex I
o	0003674	molecular_function	molecular_function
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005758	cellular_component	mitochondrial intermembrane space
o	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
o	0009060	biological_process	aerobic respiration
o	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
o	0045271	cellular_component	respiratory chain complex I
o	1902600	biological_process	proton transmembrane transport
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0009060	biological_process	aerobic respiration
p	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
p	0045271	cellular_component	respiratory chain complex I
q	0003674	molecular_function	molecular_function
q	0005739	cellular_component	mitochondrion
q	0005743	cellular_component	mitochondrial inner membrane
q	0009060	biological_process	aerobic respiration
q	0016020	cellular_component	membrane
q	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
q	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
q	0045271	cellular_component	respiratory chain complex I
r	0005739	cellular_component	mitochondrion
r	0005743	cellular_component	mitochondrial inner membrane
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0009060	biological_process	aerobic respiration
r	0042773	biological_process	ATP synthesis coupled electron transport
r	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
r	0045271	cellular_component	respiratory chain complex I
s	0005739	cellular_component	mitochondrion
s	0005743	cellular_component	mitochondrial inner membrane
s	0009060	biological_process	aerobic respiration
s	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
s	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
s	0045271	cellular_component	respiratory chain complex I

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
T	ASP39-MET54

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
T	ASP64-ILE76

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP

Chain	Residue	Details
I	CYS79-PRO90
I	CYS118-PRO129

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
D	LEU83-LYS94

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvwDMFgvfffnHpdlRrIL

Chain	Residue	Details
C	GLU131-LEU152

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
G	PRO38-CYS55

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS105-GLN117

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
G	ARG152-PHE162

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
F	GLY180-SER195

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
F	GLU357-GLY368

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GILQpFaDAMKLFmKE

Chain	Residue	Details
H	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
H	PRO197-GLY210

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
E	ASP134-PRO152

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
B	GLY145-PRO161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1279
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38575788","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	19
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Symmetric dimethylarginine","evidences":[{"source":"UniProtKB","id":"P17694","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29915388","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6G72","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"UniProtKB","id":"P19404","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	57
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	78
Details	Domain: {"description":"2Fe-2S ferredoxin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00465","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	39
Details	Domain: {"description":"4Fe-4S His(Cys)3-ligated-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	56
Details	Domain: {"description":"4Fe-4S Mo/W bis-MGD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01004","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38575788","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38575788","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38575788","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38575788","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PINK1","evidences":[{"source":"PubMed","id":"24652937","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20433953","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	75
Details	Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q16718","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q63362","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	41
Details	Domain: {"description":"CHCH 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	43
Details	Domain: {"description":"CHCH 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	30
Details	Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	30
Details	Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	10
Details	Motif: {"description":"Cx9C motif 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	10
Details	Motif: {"description":"Cx9C motif 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	86
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	12
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q9Y6M9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9Y6M9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	10
Details	Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O96000","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O95182","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P56181","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---