7AE9

Crystal structure of mono-AMPylated HEPN(R46E) toxin in complex with MNT antitoxin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0016787	molecular_function	hydrolase activity
A	0110001	cellular_component	toxin-antitoxin complex
B	0000166	molecular_function	nucleotide binding
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004540	molecular_function	RNA nuclease activity
B	0016787	molecular_function	hydrolase activity
B	0110001	cellular_component	toxin-antitoxin complex
C	0000166	molecular_function	nucleotide binding
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004540	molecular_function	RNA nuclease activity
C	0016787	molecular_function	hydrolase activity
C	0110001	cellular_component	toxin-antitoxin complex
D	0000166	molecular_function	nucleotide binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004540	molecular_function	RNA nuclease activity
D	0016787	molecular_function	hydrolase activity
D	0110001	cellular_component	toxin-antitoxin complex
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0005524	molecular_function	ATP binding
G	0016740	molecular_function	transferase activity
G	0016779	molecular_function	nucleotidyltransferase activity
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0005524	molecular_function	ATP binding
H	0016740	molecular_function	transferase activity
H	0016779	molecular_function	nucleotidyltransferase activity
H	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Active site: {"evidences":[{"source":"PubMed","id":"33290744","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"O-di-AMP-tyrosine","evidences":[{"source":"PubMed","id":"33290744","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AE6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Motif: {"description":"RX(4)HXY motif","evidences":[{"source":"PubMed","id":"33290744","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Motif: {"description":"Y-loop","evidences":[{"source":"PubMed","id":"33290744","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8ECH7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Motif: {"description":"GSX(10)DXD motif","evidences":[{"source":"UniProtKB","id":"Q8ECH7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---