7A0D

The Crystal Structure of Bovine Thrombin in complex with Hirudin (C16U/C28U) at 1.6 Angstroms Resolution

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
HHH	0004252	molecular_function	serine-type endopeptidase activity
HHH	0005509	molecular_function	calcium ion binding
HHH	0006508	biological_process	proteolysis
HHH	0007596	biological_process	blood coagulation
III	0004857	molecular_function	enzyme inhibitor activity
III	0004867	molecular_function	serine-type endopeptidase inhibitor activity
LLL	0004252	molecular_function	serine-type endopeptidase activity
LLL	0005576	cellular_component	extracellular region
LLL	0006508	biological_process	proteolysis
LLL	0007596	biological_process	blood coagulation

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
HHH	LEU39-CYS44

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
HHH	ASP199-VAL210

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by factor Xa => ECO:0000250|UniProtKB:P00734

Chain	Residue	Details
LLL	ARG36
HHH	ASP99
HHH	SER205

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000250

Chain	Residue	Details
III	THR45

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