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6ZEH

Structure of PP1-spectrin alpha II chimera [PP1(7-304) + linker (G/S)x9 + spectrin alpha II (1025-1039)] bound to Phactr1 (516-580)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000164cellular_componentprotein phosphatase type 1 complex
A0000781cellular_componentchromosome, telomeric region
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0005977biological_processglycogen metabolic process
A0005979biological_processregulation of glycogen biosynthetic process
A0005981biological_processregulation of glycogen catabolic process
A0006338biological_processchromatin remodeling
A0006357biological_processregulation of transcription by RNA polymerase II
A0006470biological_processprotein dephosphorylation
A0008157molecular_functionprotein phosphatase 1 binding
A0010288biological_processresponse to lead ion
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0017018molecular_functionmyosin phosphatase activity
A0030324biological_processlung development
A0032922biological_processcircadian regulation of gene expression
A0033192molecular_functioncalmodulin-dependent protein phosphatase activity
A0042587cellular_componentglycogen granule
A0042752biological_processregulation of circadian rhythm
A0043021molecular_functionribonucleoprotein complex binding
A0043025cellular_componentneuronal cell body
A0043153biological_processentrainment of circadian clock by photoperiod
A0043197cellular_componentdendritic spine
A0043204cellular_componentperikaryon
A0043247biological_processtelomere maintenance in response to DNA damage
A0043558biological_processregulation of translational initiation in response to stress
A0044877molecular_functionprotein-containing complex binding
A0045725biological_processpositive regulation of glycogen biosynthetic process
A0046872molecular_functionmetal ion binding
A0046914molecular_functiontransition metal ion binding
A0048754biological_processbranching morphogenesis of an epithelial tube
A0051301biological_processcell division
A0060828biological_processregulation of canonical Wnt signaling pathway
A0070062cellular_componentextracellular exosome
A0072357cellular_componentPTW/PP1 phosphatase complex
A0098609biological_processcell-cell adhesion
A0098641molecular_functioncadherin binding involved in cell-cell adhesion
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0140791molecular_functionhistone H2AXS140 phosphatase activity
A0180004molecular_functionRNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
A0180005molecular_functionRNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
A0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
A0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
A1990439molecular_functionMAP kinase serine/threonine phosphatase activity
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0000164cellular_componentprotein phosphatase type 1 complex
B0000781cellular_componentchromosome, telomeric region
B0004721molecular_functionphosphoprotein phosphatase activity
B0004722molecular_functionprotein serine/threonine phosphatase activity
B0005506molecular_functioniron ion binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005912cellular_componentadherens junction
B0005977biological_processglycogen metabolic process
B0005979biological_processregulation of glycogen biosynthetic process
B0005981biological_processregulation of glycogen catabolic process
B0006338biological_processchromatin remodeling
B0006357biological_processregulation of transcription by RNA polymerase II
B0006470biological_processprotein dephosphorylation
B0008157molecular_functionprotein phosphatase 1 binding
B0010288biological_processresponse to lead ion
B0016311biological_processdephosphorylation
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0017018molecular_functionmyosin phosphatase activity
B0030324biological_processlung development
B0032922biological_processcircadian regulation of gene expression
B0033192molecular_functioncalmodulin-dependent protein phosphatase activity
B0042587cellular_componentglycogen granule
B0042752biological_processregulation of circadian rhythm
B0043021molecular_functionribonucleoprotein complex binding
B0043025cellular_componentneuronal cell body
B0043153biological_processentrainment of circadian clock by photoperiod
B0043197cellular_componentdendritic spine
B0043204cellular_componentperikaryon
B0043247biological_processtelomere maintenance in response to DNA damage
B0043558biological_processregulation of translational initiation in response to stress
B0044877molecular_functionprotein-containing complex binding
B0045725biological_processpositive regulation of glycogen biosynthetic process
B0046872molecular_functionmetal ion binding
B0046914molecular_functiontransition metal ion binding
B0048754biological_processbranching morphogenesis of an epithelial tube
B0051301biological_processcell division
B0060828biological_processregulation of canonical Wnt signaling pathway
B0070062cellular_componentextracellular exosome
B0072357cellular_componentPTW/PP1 phosphatase complex
B0098609biological_processcell-cell adhesion
B0098641molecular_functioncadherin binding involved in cell-cell adhesion
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0140791molecular_functionhistone H2AXS140 phosphatase activity
B0180004molecular_functionRNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
B0180005molecular_functionRNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
B0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
B0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
B0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
B1990439molecular_functionMAP kinase serine/threonine phosphatase activity
B2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue MN A 501
ChainResidue
AASP92
AASN124
AHIS173
AHIS248
AMN502
APO4503

site_idAC2
Number of Residues6
Detailsbinding site for residue MN A 502
ChainResidue
AMN501
APO4503
AHOH766
AASP64
AHIS66
AASP92

site_idAC3
Number of Residues14
Detailsbinding site for residue PO4 A 503
ChainResidue
AASP64
AHIS66
AASP92
AASN124
AHIS125
AARG221
AHIS248
AALA328
ASER329
AMN501
AMN502
AHOH621
AHOH670
AHOH766

site_idAC4
Number of Residues6
Detailsbinding site for residue MN B 501
ChainResidue
BASP92
BASN124
BHIS173
BHIS248
BMN502
BPO4503

site_idAC5
Number of Residues6
Detailsbinding site for residue MN B 502
ChainResidue
BASP64
BHIS66
BASP92
BMN501
BPO4503
BHOH767

site_idAC6
Number of Residues14
Detailsbinding site for residue PO4 B 503
ChainResidue
BASP64
BHIS66
BASP92
BASN124
BHIS125
BARG221
BHIS248
BALA328
BSER329
BMN501
BMN502
BHOH617
BHOH621
BHOH767

site_idAC7
Number of Residues7
Detailsbinding site for residue SO4 B 504
ChainResidue
BPRO58
BLEU59
BLYS60
BSER85
BASN86
BHOH604
BHOH698

Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
ALEU121-GLU126

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:P36873
ChainResidueDetails
AHIS125
BHIS125

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0007744|PDB:6CZO, ECO:0007744|PDB:7TVF, ECO:0007744|PDB:7TXH, ECO:0007744|PDB:7UPI
ChainResidueDetails
AASP64
BASN124
BHIS173
BHIS248
AHIS66
AASP92
AASN124
AHIS173
AHIS248
BASP64
BHIS66
BASP92

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER22
BSER22

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P16546
ChainResidueDetails
ASER327
BSER327

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER329
BSER329

229183

PDB entries from 2024-12-18

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