6ZEE

Structure of PP1(7-300) bound to Phactr1 (507-580) at pH8.4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
B	0016787	molecular_function	hydrolase activity
I	0016787	molecular_function	hydrolase activity
K	0016787	molecular_function	hydrolase activity
P	0016787	molecular_function	hydrolase activity
Q	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MN P 501

Chain	Residue
P	ASP92
P	ASN124
P	HIS173
P	HIS248
P	MN502
P	SO4512

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MN P 502

Chain	Residue
P	MN501
P	SO4512
P	HOH623
P	ASP64
P	HIS66
P	ASP92

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO P 503

Chain	Residue
P	VAL28
P	LEU30
P	ILE35
P	GLU102
P	ARG143
P	TYR144

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO P 504

Chain	Residue
P	PHE81
P	PRO82
P	TYR110
P	TYR114
Q	PRO178

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO P 505

Chain	Residue
P	PRO60
P	LEU60
P	SER85
P	ASN86

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO P 506

Chain	Residue
P	ARG132
P	ILE133
P	ASP138

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO P 507

Chain	Residue
P	PRO196
P	ASP197
P	GLN198
W	HIS573
W	LEU574
W	THR575

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO P 508

Chain	Residue
P	PRO196
P	LEU200
P	LEU201
P	HOH647
W	LEU574

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL P 509

Chain	Residue
P	PRO196
P	TRP206
P	HOH634
P	HOH656
W	ARG576

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO P 510

Chain	Residue
P	SER182
P	MET183
P	GLU184
P	ARG187
P	HIS239

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO P 511

Chain	Residue
P	ASN271
P	GLY274
W	TYR534
W	ASP535
W	ARG536

---

site_id	AD3
Number of Residues	11
Details	binding site for residue SO4 P 512

Chain	Residue
P	HIS66
P	ASP92
P	ARG96
P	ASN124
P	HIS125
P	ARG221
P	HIS248
P	MN501
P	MN502
P	HOH623
P	HOH667

---

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 P 513

Chain	Residue
P	GLU18
Q	GLU218

---

site_id	AD5
Number of Residues	7
Details	binding site for residue MN Q 501

Chain	Residue
Q	ASP92
Q	ASN124
Q	HIS173
Q	HIS248
Q	MN502
Q	SO4508
Q	HOH601

---

site_id	AD6
Number of Residues	6
Details	binding site for residue MN Q 502

Chain	Residue
Q	ASP64
Q	HIS66
Q	ASP92
Q	MN501
Q	SO4508
Q	HOH601

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO Q 503

Chain	Residue
P	GLU218
P	HOH606
Q	GLU18

---

site_id	AD8
Number of Residues	4
Details	binding site for residue EDO Q 504

Chain	Residue
Q	ARG132
Q	ILE133
Q	ASP138
V	TRP542

---

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO Q 505

Chain	Residue
Q	GLN249
Q	GLU256
Q	PHE257
Q	HOH604

---

site_id	AE1
Number of Residues	5
Details	binding site for residue EDO Q 506

Chain	Residue
Q	SER182
Q	MET183
Q	GLU184
Q	ARG187
Q	HIS239

---

site_id	AE2
Number of Residues	5
Details	binding site for residue EDO Q 507

Chain	Residue
Q	GLY21
Q	ARG74
Q	GLU77
V	GLN532
P	GLN214

---

site_id	AE3
Number of Residues	11
Details	binding site for residue SO4 Q 508

Chain	Residue
Q	HIS66
Q	ASP92
Q	ARG96
Q	ASN124
Q	HIS125
Q	ARG221
Q	HIS248
Q	MN501
Q	MN502
Q	HOH601
Q	HOH624

---

site_id	AE4
Number of Residues	7
Details	binding site for residue MN B 501

Chain	Residue
B	ASP92
B	ASN124
B	HIS173
B	HIS248
B	MN502
B	SO4516
B	HOH632

---

site_id	AE5
Number of Residues	7
Details	binding site for residue MN B 502

Chain	Residue
B	ASP64
B	HIS66
B	ASP92
B	MN501
B	SO4516
B	HOH632
B	HOH644

---

site_id	AE6
Number of Residues	5
Details	binding site for residue EDO B 503

Chain	Residue
B	LEU17
B	PHE81
B	PRO82
B	TYR110
B	TYR114

---

site_id	AE7
Number of Residues	5
Details	binding site for residue EDO B 504

Chain	Residue
B	SER182
B	MET183
B	GLU184
B	HIS239
B	HOH602

---

site_id	AE8
Number of Residues	3
Details	binding site for residue EDO B 505

Chain	Residue
B	GLN249
B	GLU256
B	HOH634

---

site_id	AE9
Number of Residues	6
Details	binding site for residue EDO B 506

Chain	Residue
B	GLY21
B	TYR70
B	ARG74
B	GLU77
B	HOH613
D	GLN532

---

site_id	AF1
Number of Residues	6
Details	binding site for residue EDO B 507

Chain	Residue
B	VAL28
B	LEU30
B	ILE35
B	GLU102
B	ARG143
B	TYR144

---

site_id	AF2
Number of Residues	4
Details	binding site for residue EDO B 508

Chain	Residue
B	ARG132
B	ILE133
B	ASP138
D	TRP542

---

site_id	AF3
Number of Residues	7
Details	binding site for residue EDO B 509

Chain	Residue
B	ASP208
B	GLU218
B	ASN219
B	ASP220
B	THR226
B	GLN249
B	HOH614

---

site_id	AF4
Number of Residues	6
Details	binding site for residue EDO B 510

Chain	Residue
B	PRO58
B	LEU59
B	SER85
B	ASN86
B	VAL285
B	HOH669

---

site_id	AF5
Number of Residues	4
Details	binding site for residue EDO B 511

Chain	Residue
B	ARG96
B	TYR272
B	SO4516
B	HOH685

---

site_id	AF6
Number of Residues	6
Details	binding site for residue EDO B 512

Chain	Residue
B	PRO196
B	ASP197
B	GLN198
D	HIS573
D	LEU574
D	THR575

---

site_id	AF7
Number of Residues	5
Details	binding site for residue EDO B 513

Chain	Residue
B	ARG96
B	GLY97
B	HOH606
D	ALA538
D	ASP539

---

site_id	AF8
Number of Residues	5
Details	binding site for residue EDO B 514

Chain	Residue
B	GLU18
B	ASP210
B	HOH601
B	HOH614
B	HOH622

---

site_id	AF9
Number of Residues	2
Details	binding site for residue EDO B 515

Chain	Residue
B	GLN29
B	ARG143

---

site_id	AG1
Number of Residues	14
Details	binding site for residue SO4 B 516

Chain	Residue
B	HIS66
B	ASP92
B	ARG96
B	ASN124
B	HIS125
B	ARG221
B	HIS248
B	MN501
B	MN502
B	EDO511
B	HOH632
B	HOH644
B	HOH670
B	HOH691

---

site_id	AG2
Number of Residues	5
Details	binding site for residue SO4 B 517

Chain	Residue
B	ALA259
B	LYS260
B	HOH624
B	HOH647
U	ASP539

---

site_id	AG3
Number of Residues	7
Details	binding site for residue MN A 501

Chain	Residue
A	ASP92
A	ASN124
A	HIS173
A	HIS248
A	MN502
A	SO4518
A	HOH604

---

site_id	AG4
Number of Residues	7
Details	binding site for residue MN A 502

Chain	Residue
A	ASP64
A	HIS66
A	ASP92
A	MN501
A	SO4518
A	HOH604
A	HOH606

---

site_id	AG5
Number of Residues	5
Details	binding site for residue EDO A 503

Chain	Residue
A	PHE81
A	PRO82
A	TYR110
A	TYR114
A	PRO178

---

site_id	AG6
Number of Residues	2
Details	binding site for residue EDO A 504

Chain	Residue
A	THR31
A	ASN33

---

site_id	AG7
Number of Residues	6
Details	binding site for residue EDO A 505

Chain	Residue
A	VAL28
A	LEU30
A	ILE35
A	GLU102
A	ARG143
A	TYR144

---

site_id	AG8
Number of Residues	5
Details	binding site for residue EDO A 506

Chain	Residue
A	SER182
A	MET183
A	GLU184
A	ARG187
A	HOH681

---

site_id	AG9
Number of Residues	4
Details	binding site for residue EDO A 507

Chain	Residue
A	ARG132
A	ILE133
A	ASP138
A	EDO517

---

site_id	AH1
Number of Residues	7
Details	binding site for residue EDO A 508

Chain	Residue
A	HIS248
A	GLN249
A	VAL250
A	TYR272
A	SO4518
A	HOH606
A	HOH703

---

site_id	AH2
Number of Residues	12
Details	binding site for residue 16P A 509

Chain	Residue
A	LEU47
A	ILE51
A	ARG187
A	ILE189
A	MET190
A	ARG191
A	EDO510
A	HOH710
B	LEU47
B	SER48
B	HOH603
B	HOH630

---

site_id	AH3
Number of Residues	4
Details	binding site for residue EDO A 510

Chain	Residue
A	PRO50
A	16P509
B	LEU47
B	SER48

---

site_id	AH4
Number of Residues	3
Details	binding site for residue EDO A 511

Chain	Residue
A	GLU116
A	HOH608
A	HOH659

---

site_id	AH5
Number of Residues	4
Details	binding site for residue EDO A 512

Chain	Residue
A	ARG132
A	TRP149
A	HOH687
C	GLU556

---

site_id	AH6
Number of Residues	3
Details	binding site for residue EDO A 513

Chain	Residue
A	GLU18
A	ASP220
A	HOH610

---

site_id	AH7
Number of Residues	6
Details	binding site for residue EDO A 514

Chain	Residue
A	ASP197
A	GLY222
A	VAL223
A	HOH607
A	HOH692
C	GOL601

---

site_id	AH8
Number of Residues	6
Details	binding site for residue EDO A 515

Chain	Residue
A	PRO196
A	ASP197
C	HIS573
C	LEU574
C	THR575
C	ARG576

---

site_id	AH9
Number of Residues	5
Details	binding site for residue EDO A 516

Chain	Residue
A	ARG96
A	TYR134
A	TRP206
A	ARG221
A	SO4518

---

site_id	AI1
Number of Residues	2
Details	binding site for residue EDO A 517

Chain	Residue
A	ARG132
A	EDO507

---

site_id	AI2
Number of Residues	14
Details	binding site for residue SO4 A 518

Chain	Residue
A	HIS66
A	ASP92
A	ARG96
A	ASN124
A	HIS125
A	ARG221
A	HIS248
A	MN501
A	MN502
A	EDO508
A	EDO516
A	HOH604
A	HOH606
A	HOH677

---

site_id	AI3
Number of Residues	7
Details	binding site for residue MN I 501

Chain	Residue
I	ASP92
I	ASN124
I	HIS173
I	HIS248
I	MN502
I	SO4505
I	HOH603

---

site_id	AI4
Number of Residues	6
Details	binding site for residue MN I 502

Chain	Residue
I	ASP64
I	HIS66
I	ASP92
I	MN501
I	SO4505
I	HOH603

---

site_id	AI5
Number of Residues	5
Details	binding site for residue EDO I 503

Chain	Residue
I	GLU218
I	ASN219
I	GLY222
K	ASN8
K	SER11

---

site_id	AI6
Number of Residues	3
Details	binding site for residue EDO I 504

Chain	Residue
I	GLU18
K	GLU218
K	ASP220

---

site_id	AI7
Number of Residues	9
Details	binding site for residue SO4 I 505

Chain	Residue
I	HIS66
I	ASP92
I	ARG96
I	ASN124
I	HIS125
I	ARG221
I	HIS248
I	MN501
I	MN502

---

site_id	AI8
Number of Residues	4
Details	binding site for residue SO4 I 506

Chain	Residue
I	ALA259
I	LYS260
P	LYS98
W	ASP539

---

site_id	AI9
Number of Residues	3
Details	binding site for residue EDO I 507

Chain	Residue
I	ARG132
I	ILE133
I	ASP138

---

site_id	AJ1
Number of Residues	6
Details	binding site for residue EDO I 508

Chain	Residue
I	ASP210
I	VAL213
I	GLU218
I	HOH635
I	HOH640
K	GLU18

---

site_id	AJ2
Number of Residues	4
Details	binding site for residue EDO I 509

Chain	Residue
I	SER129
I	ILE133
U	HIS578
U	EDO601

---

site_id	AJ3
Number of Residues	3
Details	binding site for residue EDO I 510

Chain	Residue
I	GLN249
I	GLU256
I	HOH604

---

site_id	AJ4
Number of Residues	6
Details	binding site for residue EDO I 511

Chain	Residue
I	VAL28
I	LEU30
I	ILE35
I	GLU102
I	ARG143
I	TYR144

---

site_id	AJ5
Number of Residues	7
Details	binding site for residue MN K 501

Chain	Residue
K	ASP92
K	ASN124
K	HIS173
K	HIS248
K	MN502
K	SO4509
K	HOH606

---

site_id	AJ6
Number of Residues	6
Details	binding site for residue MN K 502

Chain	Residue
K	ASP64
K	HIS66
K	ASP92
K	MN501
K	SO4509
K	HOH606

---

site_id	AJ7
Number of Residues	2
Details	binding site for residue EDO K 503

Chain	Residue
K	ALA259
K	LYS260

---

site_id	AJ8
Number of Residues	7
Details	binding site for residue GOL K 504

Chain	Residue
K	GLN20
K	GLY21
K	SER22
K	TYR70
K	ARG74
K	GLU77
X	GLN532

---

site_id	AJ9
Number of Residues	3
Details	binding site for residue EDO K 505

Chain	Residue
K	ARG132
K	ILE133
K	ASP138

---

site_id	AK1
Number of Residues	3
Details	binding site for residue EDO K 506

Chain	Residue
K	PRO50
K	LEU53
K	GLU116

---

site_id	AK2
Number of Residues	5
Details	binding site for residue EDO K 507

Chain	Residue
K	PRO196
K	ASP197
X	HIS573
X	LEU574
X	THR575

---

site_id	AK3
Number of Residues	7
Details	binding site for residue GOL K 508

Chain	Residue
K	LEU47
K	ILE189
K	MET190
K	ARG191
K	HOH650
P	SER48
P	HOH619

---

site_id	AK4
Number of Residues	10
Details	binding site for residue SO4 K 509

Chain	Residue
K	HIS66
K	ASP92
K	ARG96
K	ASN124
K	HIS125
K	ARG221
K	HIS248
K	MN501
K	MN502
K	HOH606

---

site_id	AK5
Number of Residues	5
Details	binding site for residue SO4 W 601

Chain	Residue
Q	SER6
W	ARG576
W	HIS578
W	ARG579
W	HOH712

---

site_id	AK6
Number of Residues	6
Details	binding site for residue GOL X 601

Chain	Residue
K	SER129
K	ILE130
K	VAL223
K	HOH662
X	ARG576
X	HIS578

---

site_id	AK7
Number of Residues	8
Details	binding site for residue GOL D 601

Chain	Residue
B	VAL195
B	PRO196
B	TRP206
B	HOH628
D	ARG576
D	HOH701
D	HOH706
D	HOH710

---

site_id	AK8
Number of Residues	2
Details	binding site for residue EDO D 602

Chain	Residue
D	LYS550
D	HOH708

---

site_id	AK9
Number of Residues	4
Details	binding site for residue SO4 D 603

Chain	Residue
D	ARG554
D	ARG576
D	HIS578
D	ARG579

---

site_id	AL1
Number of Residues	8
Details	binding site for residue GOL C 601

Chain	Residue
A	VAL195
A	PRO196
A	TRP206
A	EDO514
C	ARG576
C	HOH711
C	HOH713
C	HOH714

---

site_id	AL2
Number of Residues	3
Details	binding site for residue SO4 C 602

Chain	Residue
C	ARG576
C	HIS578
C	ARG579

---

site_id	AL3
Number of Residues	2
Details	binding site for residue EDO U 601

Chain	Residue
I	EDO509
U	ARG576

---

site_id	AL4
Number of Residues	4
Details	binding site for residue SO4 U 602

Chain	Residue
K	SER6
U	ARG576
U	HIS578
U	ARG579

---

site_id	AL5
Number of Residues	3
Details	binding site for residue EDO V 601

Chain	Residue
V	ARG576
V	HOH709
V	HOH710

---

site_id	AL6
Number of Residues	3
Details	binding site for residue SO4 V 602

Chain	Residue
V	ARG576
V	HIS578
V	ARG579

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
P	LEU121-GLU126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30100357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35830882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35831509","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36175670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39446389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SW5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---