6Z2H

Citryl-CoA lyase module of human ATP citrate lyase in complex with (3S)-citryl-CoA.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
B	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
C	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
D	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	binding site for residue Q5B A 1201

Chain	Residue
A	HIS900
A	GLY972
A	ILE973
A	GLY974
A	HIS975
A	ARG976
A	ARG986
A	LYS1018
A	ASN1020
A	LEU1021
A	ASN1024
A	VAL904
A	ASP1026
A	ARG1065
A	OAA1202
A	ACO1203
A	HOH1319
A	HOH1342
A	HOH1365
A	HOH1391
A	HOH1406
A	HOH1409
A	ASP933
A	HOH1410
B	ASP1089
D	LYS836
D	ARG1085
A	ARG934
A	PHE935
A	GLY936
A	ALA938
A	LEU969
A	ILE970

---

site_id	AC2
Number of Residues	11
Details	binding site for residue OAA A 1202

Chain	Residue
A	HIS900
A	VAL904
A	PHE935
A	HIS975
A	ARG986
A	ARG1065
A	Q5B1201
A	ACO1203
A	HOH1365
A	HOH1409
D	ARG1085

---

site_id	AC3
Number of Residues	24
Details	binding site for residue ACO A 1203

Chain	Residue
A	ASP933
A	ARG934
A	GLY936
A	ALA938
A	LEU969
A	ILE970
A	GLY972
A	ILE973
A	GLY974
A	HIS975
A	ARG976
A	LYS1018
A	ASN1020
A	LEU1021
A	ASN1024
A	ASP1026
A	Q5B1201
A	OAA1202
A	HOH1319
A	HOH1342
A	HOH1391
A	HOH1406
B	ASP1089
D	LYS836

---

site_id	AC4
Number of Residues	28
Details	binding site for residue Q5B C 1201

Chain	Residue
B	ARG1085
C	HIS900
C	VAL904
C	ASP933
C	ARG934
C	PHE935
C	GLY936
C	ALA938
C	LEU969
C	ILE970
C	GLY972
C	ILE973
C	GLY974
C	HIS975
C	ARG976
C	ARG986
C	LEU1021
C	ASN1024
C	ASP1026
C	ARG1065
C	OAA1202
C	ACO1203
C	HOH1320
C	HOH1350
C	HOH1372
C	HOH1410
C	HOH1425
C	HOH1429

---

site_id	AC5
Number of Residues	11
Details	binding site for residue OAA C 1202

Chain	Residue
C	PHE935
C	HIS975
C	ARG986
C	ARG1065
C	Q5B1201
C	ACO1203
C	HOH1350
C	HOH1372
B	ARG1085
C	HIS900
C	VAL904

---

site_id	AC6
Number of Residues	20
Details	binding site for residue ACO C 1203

Chain	Residue
C	ASP933
C	ARG934
C	GLY936
C	ALA938
C	LEU969
C	ILE970
C	GLY972
C	ILE973
C	GLY974
C	ARG976
C	LEU1021
C	ASN1024
C	ASP1026
C	PHE1061
C	Q5B1201
C	OAA1202
C	HOH1320
C	HOH1410
C	HOH1425
C	HOH1429

---

site_id	AC7
Number of Residues	22
Details	binding site for residue Q5B D 1201

Chain	Residue
A	ARG1085
D	HIS900
D	VAL904
D	ALA938
D	LYS964
D	LEU969
D	ILE970
D	MET971
D	GLY972
D	ILE973
D	GLY974
D	HIS975
D	ARG986
D	ASN1020
D	LEU1021
D	ASN1024
D	ASP1026
D	HOH1315
D	HOH1337
D	HOH1406
D	HOH1414
D	HOH1415

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER839
B	SER839
C	SER839
D	SER839

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS948
D	LYS948
D	LYS968
D	LYS1077
A	LYS968
A	LYS1077
B	LYS948
B	LYS968
B	LYS1077
C	LYS948
C	LYS968
C	LYS1077

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q91V92

Chain	Residue	Details
A	LYS978
B	LYS978
C	LYS978
D	LYS978

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER1100
B	SER1100
C	SER1100
D	SER1100

---