6YOQ
Crystal structure of YTHDC1 with compound VVR_DC1_002
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue P5H A 601 |
| Chain | Residue |
| A | LYS361 |
| A | ASP476 |
| A | SO4604 |
| A | HOH714 |
| A | HOH731 |
| A | HOH820 |
| A | HOH862 |
| A | ASN363 |
| A | ASN367 |
| A | TRP377 |
| A | SER378 |
| A | LEU380 |
| A | TRP428 |
| A | PRO431 |
| A | MET434 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 602 |
| Chain | Residue |
| A | GLY344 |
| A | THR345 |
| A | SER346 |
| A | LYS347 |
| A | HOH703 |
| A | HOH704 |
| A | HOH713 |
| A | HOH772 |
| B | LYS386 |
| B | GLU479 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | HIS420 |
| A | HIS421 |
| A | HOH707 |
| A | HOH822 |
| A | HOH864 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | ARG475 |
| A | ASP476 |
| A | P5H601 |
| A | HOH752 |
| A | HOH820 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue P5H B 601 |
| Chain | Residue |
| B | LYS361 |
| B | ASN363 |
| B | ASN367 |
| B | TRP377 |
| B | SER378 |
| B | LEU380 |
| B | TRP428 |
| B | LEU430 |
| B | MET434 |
| B | ASP476 |
| B | SO4605 |
| B | HOH746 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 602 |
| Chain | Residue |
| B | ARG451 |
| B | GLU452 |
| B | HOH714 |
| B | HOH728 |
| B | HOH747 |
| B | HOH750 |
| B | HOH770 |
| B | HOH854 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 603 |
| Chain | Residue |
| B | GLY344 |
| B | LYS347 |
| B | HOH701 |
| B | HOH709 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 604 |
| Chain | Residue |
| B | SER419 |
| B | HIS420 |
| B | HIS421 |
| B | ARG451 |
| B | HOH827 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 605 |
| Chain | Residue |
| A | SER424 |
| A | PRO425 |
| B | ARG475 |
| B | ASP476 |
| B | P5H601 |
| B | HOH759 |
| B | HOH783 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31670957, ECO:0007744|PDB:6RT4, ECO:0007744|PDB:6RT5, ECO:0007744|PDB:6RT6, ECO:0007744|PDB:6RT7 |
| Chain | Residue | Details |
| A | LYS361 | |
| A | ASP476 | |
| B | LYS361 | |
| B | ASP476 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:31670957, ECO:0007744|PDB:6RT4, ECO:0007744|PDB:6RT5, ECO:0007744|PDB:6RT6, ECO:0007744|PDB:6RT7 |
| Chain | Residue | Details |
| A | TRP377 | |
| B | TRP377 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25242552 |
| Chain | Residue | Details |
| A | TRP428 | |
| B | TRP428 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER424 | |
| B | SER424 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER435 | |
| B | SER435 |
