6YIH
Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3 peptide at 2.6 A.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000228 | cellular_component | nuclear chromosome |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0000281 | biological_process | mitotic cytokinesis |
| A | 0000775 | cellular_component | chromosome, centromeric region |
| A | 0000776 | cellular_component | kinetochore |
| A | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005819 | cellular_component | spindle |
| A | 0005829 | cellular_component | cytosol |
| A | 0005874 | cellular_component | microtubule |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007052 | biological_process | mitotic spindle organization |
| A | 0007059 | biological_process | chromosome segregation |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030414 | molecular_function | peptidase inhibitor activity |
| A | 0030496 | cellular_component | midbody |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0031503 | biological_process | protein-containing complex localization |
| A | 0032133 | cellular_component | chromosome passenger complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 0051233 | cellular_component | spindle midzone |
| A | 0051256 | biological_process | mitotic spindle midzone assembly |
| A | 0051301 | biological_process | cell division |
| A | 0090267 | biological_process | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| A | 0090307 | biological_process | mitotic spindle assembly |
| A | 1901970 | biological_process | positive regulation of mitotic sister chromatid separation |
| A | 1902425 | biological_process | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| A | 1903490 | biological_process | positive regulation of mitotic cytokinesis |
| A | 1990713 | cellular_component | survivin complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 201 |
| Chain | Residue |
| A | CYS57 |
| A | CYS60 |
| A | HIS77 |
| A | CYS84 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | PHE27 |
| A | LEU28 |
| A | GLU29 |
| A | HOH304 |
| C | HIS10 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | Repeat: {"description":"BIR"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17956729","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QFA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interaction with FBXL7","evidences":[{"source":"PubMed","id":"25778398","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKC","evidences":[{"source":"PubMed","id":"27332895","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"20826784","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by CDK1 and CDK15","evidences":[{"source":"PubMed","id":"11069302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24866247","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by CK2; in vitro","evidences":[{"source":"PubMed","id":"21252625","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by AURKB","evidences":[{"source":"PubMed","id":"14610074","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
