6YHR

Crystal structure of Werner syndrome helicase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0043138	molecular_function	3'-5' DNA helicase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ADP A 1201

Chain	Residue
A	HIS546
A	HOH1301
A	HOH1388
A	HOH1408
A	SER548
A	LYS550
A	GLN553
A	GLY574
A	GLY576
A	LYS577
A	SER578
A	ARG857

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1202

Chain	Residue
A	CYS908
A	CYS935
A	CYS936
A	CYS939

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1203

Chain	Residue
A	HIS558
A	GLU563
A	HIS808
A	GLU814

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	166
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	150
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Region: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"20159463","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33199508","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6YHR","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"6YHR","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33199508","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33199508","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6YHR","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"20159463","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---