6YBW

Structure of a human 48S translational initiation complex - 40S body

Functional Information from GO Data

Chain	GOid	namespace	contents
9	0002181	biological_process	cytoplasmic translation
9	0003723	molecular_function	RNA binding
9	0003730	molecular_function	mRNA 3'-UTR binding
9	0003735	molecular_function	structural constituent of ribosome
9	0005515	molecular_function	protein binding
9	0005737	cellular_component	cytoplasm
9	0005783	cellular_component	endoplasmic reticulum
9	0005829	cellular_component	cytosol
9	0005840	cellular_component	ribosome
9	0006412	biological_process	translation
9	0022625	cellular_component	cytosolic large ribosomal subunit
9	0048027	molecular_function	mRNA 5'-UTR binding
9	1990904	cellular_component	ribonucleoprotein complex
B	0002181	biological_process	cytoplasmic translation
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005840	cellular_component	ribosome
B	0005925	cellular_component	focal adhesion
B	0006412	biological_process	translation
B	0016020	cellular_component	membrane
B	0019843	molecular_function	rRNA binding
B	0022626	cellular_component	cytosolic ribosome
B	0022627	cellular_component	cytosolic small ribosomal subunit
B	0032040	cellular_component	small-subunit processome
B	0042274	biological_process	ribosomal small subunit biogenesis
B	0045202	cellular_component	synapse
B	0070062	cellular_component	extracellular exosome
B	1990904	cellular_component	ribonucleoprotein complex
C	0002181	biological_process	cytoplasmic translation
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005840	cellular_component	ribosome
C	0005925	cellular_component	focal adhesion
C	0006412	biological_process	translation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0015935	cellular_component	small ribosomal subunit
C	0016020	cellular_component	membrane
C	0019843	molecular_function	rRNA binding
C	0022626	cellular_component	cytosolic ribosome
C	0022627	cellular_component	cytosolic small ribosomal subunit
C	0032040	cellular_component	small-subunit processome
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0042274	biological_process	ribosomal small subunit biogenesis
C	0045202	cellular_component	synapse
C	0045727	biological_process	positive regulation of translation
C	0070062	cellular_component	extracellular exosome
C	1990904	cellular_component	ribonucleoprotein complex
D	0002181	biological_process	cytoplasmic translation
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005840	cellular_component	ribosome
D	0005925	cellular_component	focal adhesion
D	0006412	biological_process	translation
D	0006417	biological_process	regulation of translation
D	0008284	biological_process	positive regulation of cell population proliferation
D	0015935	cellular_component	small ribosomal subunit
D	0016020	cellular_component	membrane
D	0019843	molecular_function	rRNA binding
D	0022626	cellular_component	cytosolic ribosome
D	0022627	cellular_component	cytosolic small ribosomal subunit
D	0032040	cellular_component	small-subunit processome
D	0042274	biological_process	ribosomal small subunit biogenesis
D	0043226	cellular_component	organelle
D	0045182	molecular_function	translation regulator activity
D	0045202	cellular_component	synapse
D	0070062	cellular_component	extracellular exosome
D	1990904	cellular_component	ribonucleoprotein complex
E	0002181	biological_process	cytoplasmic translation
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005791	cellular_component	rough endoplasmic reticulum
E	0005829	cellular_component	cytosol
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0015935	cellular_component	small ribosomal subunit
E	0016020	cellular_component	membrane
E	0022626	cellular_component	cytosolic ribosome
E	0022627	cellular_component	cytosolic small ribosomal subunit
E	0032040	cellular_component	small-subunit processome
E	0034063	biological_process	stress granule assembly
E	0042274	biological_process	ribosomal small subunit biogenesis
E	0045202	cellular_component	synapse
E	1990145	biological_process	maintenance of translational fidelity
E	1990904	cellular_component	ribonucleoprotein complex
F	0003735	molecular_function	structural constituent of ribosome
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
G	0001843	biological_process	neural tube closure
G	0002181	biological_process	cytoplasmic translation
G	0003723	molecular_function	RNA binding
G	0003730	molecular_function	mRNA 3'-UTR binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0005840	cellular_component	ribosome
G	0005856	cellular_component	cytoskeleton
G	0005925	cellular_component	focal adhesion
G	0006364	biological_process	rRNA processing
G	0006412	biological_process	translation
G	0010628	biological_process	positive regulation of gene expression
G	0014033	biological_process	neural crest cell differentiation
G	0016020	cellular_component	membrane
G	0019901	molecular_function	protein kinase binding
G	0022626	cellular_component	cytosolic ribosome
G	0022627	cellular_component	cytosolic small ribosomal subunit
G	0032040	cellular_component	small-subunit processome
G	0032991	cellular_component	protein-containing complex
G	0042274	biological_process	ribosomal small subunit biogenesis
G	0045202	cellular_component	synapse
G	0048027	molecular_function	mRNA 5'-UTR binding
G	0050821	biological_process	protein stabilization
G	1902255	biological_process	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
G	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
G	1990904	cellular_component	ribonucleoprotein complex
G	1990948	molecular_function	ubiquitin ligase inhibitor activity
G	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
H	0000028	biological_process	ribosomal small subunit assembly
H	0002181	biological_process	cytoplasmic translation
H	0003677	molecular_function	DNA binding
H	0003723	molecular_function	RNA binding
H	0003735	molecular_function	structural constituent of ribosome
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005730	cellular_component	nucleolus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005840	cellular_component	ribosome
H	0006364	biological_process	rRNA processing
H	0006412	biological_process	translation
H	0008270	molecular_function	zinc ion binding
H	0014069	cellular_component	postsynaptic density
H	0022626	cellular_component	cytosolic ribosome
H	0022627	cellular_component	cytosolic small ribosomal subunit
H	0032040	cellular_component	small-subunit processome
H	0042274	biological_process	ribosomal small subunit biogenesis
H	0046872	molecular_function	metal ion binding
H	1990904	cellular_component	ribonucleoprotein complex
I	0002181	biological_process	cytoplasmic translation
I	0003723	molecular_function	RNA binding
I	0003729	molecular_function	mRNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005840	cellular_component	ribosome
I	0005925	cellular_component	focal adhesion
I	0006412	biological_process	translation
I	0014069	cellular_component	postsynaptic density
I	0016020	cellular_component	membrane
I	0022626	cellular_component	cytosolic ribosome
I	0022627	cellular_component	cytosolic small ribosomal subunit
I	0032040	cellular_component	small-subunit processome
I	0033119	biological_process	negative regulation of RNA splicing
I	0042274	biological_process	ribosomal small subunit biogenesis
I	0048027	molecular_function	mRNA 5'-UTR binding
I	0070062	cellular_component	extracellular exosome
I	0070181	molecular_function	small ribosomal subunit rRNA binding
I	1990904	cellular_component	ribonucleoprotein complex
J	0002181	biological_process	cytoplasmic translation
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005840	cellular_component	ribosome
J	0006412	biological_process	translation
J	0008284	biological_process	positive regulation of cell population proliferation
J	0009615	biological_process	response to virus
J	0016020	cellular_component	membrane
J	0022626	cellular_component	cytosolic ribosome
J	0022627	cellular_component	cytosolic small ribosomal subunit
J	0032040	cellular_component	small-subunit processome
J	0042274	biological_process	ribosomal small subunit biogenesis
J	0045202	cellular_component	synapse
J	0045787	biological_process	positive regulation of cell cycle
J	0070062	cellular_component	extracellular exosome
J	1990904	cellular_component	ribonucleoprotein complex
K	0000447	biological_process	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0000461	biological_process	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0002181	biological_process	cytoplasmic translation
K	0003723	molecular_function	RNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0005515	molecular_function	protein binding
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005783	cellular_component	endoplasmic reticulum
K	0005791	cellular_component	rough endoplasmic reticulum
K	0005829	cellular_component	cytosol
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0015935	cellular_component	small ribosomal subunit
K	0022626	cellular_component	cytosolic ribosome
K	0022627	cellular_component	cytosolic small ribosomal subunit
K	0045202	cellular_component	synapse
K	1990904	cellular_component	ribonucleoprotein complex
L	0002181	biological_process	cytoplasmic translation
L	0003723	molecular_function	RNA binding
L	0003729	molecular_function	mRNA binding
L	0003735	molecular_function	structural constituent of ribosome
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005840	cellular_component	ribosome
L	0005925	cellular_component	focal adhesion
L	0006412	biological_process	translation
L	0015935	cellular_component	small ribosomal subunit
L	0016020	cellular_component	membrane
L	0017134	molecular_function	fibroblast growth factor binding
L	0019899	molecular_function	enzyme binding
L	0022626	cellular_component	cytosolic ribosome
L	0022627	cellular_component	cytosolic small ribosomal subunit
L	0045296	molecular_function	cadherin binding
L	0051443	biological_process	positive regulation of ubiquitin-protein transferase activity
L	0070062	cellular_component	extracellular exosome
L	1990904	cellular_component	ribonucleoprotein complex
M	0002181	biological_process	cytoplasmic translation
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005730	cellular_component	nucleolus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005840	cellular_component	ribosome
M	0005925	cellular_component	focal adhesion
M	0006364	biological_process	rRNA processing
M	0006412	biological_process	translation
M	0006413	biological_process	translational initiation
M	0016020	cellular_component	membrane
M	0022626	cellular_component	cytosolic ribosome
M	0022627	cellular_component	cytosolic small ribosomal subunit
M	0032040	cellular_component	small-subunit processome
M	0034101	biological_process	erythrocyte homeostasis
M	0042274	biological_process	ribosomal small subunit biogenesis
M	0045202	cellular_component	synapse
M	1990904	cellular_component	ribonucleoprotein complex
N	0000028	biological_process	ribosomal small subunit assembly
N	0001618	molecular_function	virus receptor activity
N	0002181	biological_process	cytoplasmic translation
N	0003677	molecular_function	DNA binding
N	0003723	molecular_function	RNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005055	molecular_function	laminin receptor activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005840	cellular_component	ribosome
N	0005886	cellular_component	plasma membrane
N	0006412	biological_process	translation
N	0007155	biological_process	cell adhesion
N	0015935	cellular_component	small ribosomal subunit
N	0016020	cellular_component	membrane
N	0022626	cellular_component	cytosolic ribosome
N	0022627	cellular_component	cytosolic small ribosomal subunit
N	0043022	molecular_function	ribosome binding
N	0043236	molecular_function	laminin binding
N	0046718	biological_process	symbiont entry into host cell
N	0070062	cellular_component	extracellular exosome
N	0140374	biological_process	antiviral innate immune response
N	1990904	cellular_component	ribonucleoprotein complex
O	0002181	biological_process	cytoplasmic translation
O	0003723	molecular_function	RNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005730	cellular_component	nucleolus
O	0005737	cellular_component	cytoplasm
O	0005783	cellular_component	endoplasmic reticulum
O	0005829	cellular_component	cytosol
O	0005840	cellular_component	ribosome
O	0005925	cellular_component	focal adhesion
O	0006412	biological_process	translation
O	0006413	biological_process	translational initiation
O	0022626	cellular_component	cytosolic ribosome
O	0022627	cellular_component	cytosolic small ribosomal subunit
O	0030154	biological_process	cell differentiation
O	0032040	cellular_component	small-subunit processome
O	0042274	biological_process	ribosomal small subunit biogenesis
O	0043066	biological_process	negative regulation of apoptotic process
O	0045202	cellular_component	synapse
O	0048027	molecular_function	mRNA 5'-UTR binding
O	0070062	cellular_component	extracellular exosome
O	1990904	cellular_component	ribonucleoprotein complex
p	0003723	molecular_function	RNA binding
p	0003743	molecular_function	translation initiation factor activity
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005737	cellular_component	cytoplasm
p	0006412	biological_process	translation
p	0006413	biological_process	translational initiation
p	0006446	biological_process	regulation of translational initiation
p	0008135	molecular_function	translation factor activity, RNA binding
p	0016282	cellular_component	eukaryotic 43S preinitiation complex
p	0033290	cellular_component	eukaryotic 48S preinitiation complex
p	0043024	molecular_function	ribosomal small subunit binding
p	0043614	cellular_component	multi-eIF complex
p	1905746	biological_process	positive regulation of mRNA cis splicing, via spliceosome
P	0000028	biological_process	ribosomal small subunit assembly
P	0000122	biological_process	negative regulation of transcription by RNA polymerase II
P	0002181	biological_process	cytoplasmic translation
P	0003723	molecular_function	RNA binding
P	0003735	molecular_function	structural constituent of ribosome
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005730	cellular_component	nucleolus
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005840	cellular_component	ribosome
P	0005925	cellular_component	focal adhesion
P	0006412	biological_process	translation
P	0006417	biological_process	regulation of translation
P	0014069	cellular_component	postsynaptic density
P	0015935	cellular_component	small ribosomal subunit
P	0016020	cellular_component	membrane
P	0022626	cellular_component	cytosolic ribosome
P	0022627	cellular_component	cytosolic small ribosomal subunit
P	0030218	biological_process	erythrocyte differentiation
P	0030490	biological_process	maturation of SSU-rRNA
P	0032040	cellular_component	small-subunit processome
P	0042274	biological_process	ribosomal small subunit biogenesis
P	0045182	molecular_function	translation regulator activity
P	0045202	cellular_component	synapse
P	0048027	molecular_function	mRNA 5'-UTR binding
P	0070062	cellular_component	extracellular exosome
P	1990904	cellular_component	ribonucleoprotein complex
q	0000049	molecular_function	tRNA binding
q	0003723	molecular_function	RNA binding
q	0003743	molecular_function	translation initiation factor activity
q	0005515	molecular_function	protein binding
q	0005737	cellular_component	cytoplasm
q	0005829	cellular_component	cytosol
q	0006412	biological_process	translation
q	0006413	biological_process	translational initiation
q	0008135	molecular_function	translation factor activity, RNA binding
q	0016282	cellular_component	eukaryotic 43S preinitiation complex
q	0033290	cellular_component	eukaryotic 48S preinitiation complex
q	0042255	biological_process	ribosome assembly
q	0043614	cellular_component	multi-eIF complex
Q	0002181	biological_process	cytoplasmic translation
Q	0003723	molecular_function	RNA binding
Q	0003729	molecular_function	mRNA binding
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005515	molecular_function	protein binding
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005783	cellular_component	endoplasmic reticulum
Q	0005791	cellular_component	rough endoplasmic reticulum
Q	0005829	cellular_component	cytosol
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0015935	cellular_component	small ribosomal subunit
Q	0016020	cellular_component	membrane
Q	0022626	cellular_component	cytosolic ribosome
Q	0022627	cellular_component	cytosolic small ribosomal subunit
Q	0033119	biological_process	negative regulation of RNA splicing
Q	0045202	cellular_component	synapse
Q	0045296	molecular_function	cadherin binding
Q	0070062	cellular_component	extracellular exosome
Q	0098556	cellular_component	cytoplasmic side of rough endoplasmic reticulum membrane
Q	1990904	cellular_component	ribonucleoprotein complex
R	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
R	0002181	biological_process	cytoplasmic translation
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005730	cellular_component	nucleolus
R	0005737	cellular_component	cytoplasm
R	0005783	cellular_component	endoplasmic reticulum
R	0005829	cellular_component	cytosol
R	0005840	cellular_component	ribosome
R	0005925	cellular_component	focal adhesion
R	0006412	biological_process	translation
R	0016020	cellular_component	membrane
R	0022626	cellular_component	cytosolic ribosome
R	0022627	cellular_component	cytosolic small ribosomal subunit
R	0032040	cellular_component	small-subunit processome
R	0042274	biological_process	ribosomal small subunit biogenesis
R	0070062	cellular_component	extracellular exosome
R	1990904	cellular_component	ribonucleoprotein complex
S	0000082	biological_process	G1/S transition of mitotic cell cycle
S	0000278	biological_process	mitotic cell cycle
S	0001890	biological_process	placenta development
S	0002181	biological_process	cytoplasmic translation
S	0002309	biological_process	T cell proliferation involved in immune response
S	0003723	molecular_function	RNA binding
S	0003735	molecular_function	structural constituent of ribosome
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005730	cellular_component	nucleolus
S	0005737	cellular_component	cytoplasm
S	0005783	cellular_component	endoplasmic reticulum
S	0005829	cellular_component	cytosol
S	0005840	cellular_component	ribosome
S	0006364	biological_process	rRNA processing
S	0006412	biological_process	translation
S	0006924	biological_process	activation-induced cell death of T cells
S	0007369	biological_process	gastrulation
S	0008284	biological_process	positive regulation of cell population proliferation
S	0015935	cellular_component	small ribosomal subunit
S	0016020	cellular_component	membrane
S	0019901	molecular_function	protein kinase binding
S	0022605	biological_process	mammalian oogenesis stage
S	0022626	cellular_component	cytosolic ribosome
S	0022627	cellular_component	cytosolic small ribosomal subunit
S	0030425	cellular_component	dendrite
S	0031929	biological_process	TOR signaling
S	0032040	cellular_component	small-subunit processome
S	0033077	biological_process	T cell differentiation in thymus
S	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
S	0042274	biological_process	ribosomal small subunit biogenesis
S	0042593	biological_process	glucose homeostasis
S	0043065	biological_process	positive regulation of apoptotic process
S	0043066	biological_process	negative regulation of apoptotic process
S	0044297	cellular_component	cell body
S	0048471	cellular_component	perinuclear region of cytoplasm
S	0048821	biological_process	erythrocyte development
S	1990904	cellular_component	ribonucleoprotein complex
T	0002181	biological_process	cytoplasmic translation
T	0003723	molecular_function	RNA binding
T	0003735	molecular_function	structural constituent of ribosome
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005730	cellular_component	nucleolus
T	0005737	cellular_component	cytoplasm
T	0005783	cellular_component	endoplasmic reticulum
T	0005829	cellular_component	cytosol
T	0005840	cellular_component	ribosome
T	0006364	biological_process	rRNA processing
T	0006412	biological_process	translation
T	0015935	cellular_component	small ribosomal subunit
T	0016020	cellular_component	membrane
T	0022626	cellular_component	cytosolic ribosome
T	0022627	cellular_component	cytosolic small ribosomal subunit
T	0031369	molecular_function	translation initiation factor binding
T	0032040	cellular_component	small-subunit processome
T	0034101	biological_process	erythrocyte homeostasis
T	0042274	biological_process	ribosomal small subunit biogenesis
T	0044391	cellular_component	ribosomal subunit
T	1990904	cellular_component	ribonucleoprotein complex
y	0001732	biological_process	formation of cytoplasmic translation initiation complex
y	0002183	biological_process	cytoplasmic translational initiation
y	0003723	molecular_function	RNA binding
y	0003743	molecular_function	translation initiation factor activity
y	0005515	molecular_function	protein binding
y	0005737	cellular_component	cytoplasm
y	0005829	cellular_component	cytosol
y	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
y	0006412	biological_process	translation
y	0006413	biological_process	translational initiation
y	0016282	cellular_component	eukaryotic 43S preinitiation complex
y	0031369	molecular_function	translation initiation factor binding
y	0032991	cellular_component	protein-containing complex
y	0033290	cellular_component	eukaryotic 48S preinitiation complex
y	0043022	molecular_function	ribosome binding
y	0045727	biological_process	positive regulation of translation
y	1902416	biological_process	positive regulation of mRNA binding
z	0001732	biological_process	formation of cytoplasmic translation initiation complex
z	0002183	biological_process	cytoplasmic translational initiation
z	0003743	molecular_function	translation initiation factor activity
z	0005515	molecular_function	protein binding
z	0005737	cellular_component	cytoplasm
z	0005829	cellular_component	cytosol
z	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
z	0006412	biological_process	translation
z	0006413	biological_process	translational initiation
z	0016282	cellular_component	eukaryotic 43S preinitiation complex
z	0033290	cellular_component	eukaryotic 48S preinitiation complex
z	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN Q 201

Chain	Residue
Q	CYS23
Q	CYS26
Q	CYS74
Q	CYS77

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG S 301

Chain	Residue
A	U314
A	C315
S	GLN177

---

site_id	AC3
Number of Residues	1
Details	binding site for residue MG A 1903

Chain	Residue
A	G999

---

site_id	AC4
Number of Residues	1
Details	binding site for residue MG A 1904

Chain	Residue
A	A449

---

site_id	AC5
Number of Residues	2
Details	binding site for residue MG A 1905

Chain	Residue
A	G434
A	C450

---

site_id	AC6
Number of Residues	1
Details	binding site for residue MG A 1906

Chain	Residue
A	G16

---

site_id	AC7
Number of Residues	1
Details	binding site for residue MG A 1907

Chain	Residue
A	G94

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MG A 1908

Chain	Residue
A	A654
A	G656

---

site_id	AC9
Number of Residues	2
Details	binding site for residue MG A 1909

Chain	Residue
A	G94
A	G451

---

site_id	AD1
Number of Residues	1
Details	binding site for residue MG A 1910

Chain	Residue
A	C48

---

site_id	AD2
Number of Residues	1
Details	binding site for residue MG A 1911

Chain	Residue
A	C472

---

site_id	AD3
Number of Residues	2
Details	binding site for residue MG A 1912

Chain	Residue
A	C663
A	C1153

---

site_id	AD4
Number of Residues	4
Details	binding site for residue MG A 1913

Chain	Residue
A	6MZ1832
A	G1837
A	U1839
A	U1840

---

site_id	AD5
Number of Residues	4
Details	binding site for residue MG A 1914

Chain	Residue
A	A1831
A	6MZ1832
A	U1840
A	C1853

---

site_id	AD6
Number of Residues	4
Details	binding site for residue MG A 1915

Chain	Residue
A	UR31830
A	A1831
A	6MZ1832
A	G1837

---

site_id	AD7
Number of Residues	2
Details	binding site for residue MG A 1916

Chain	Residue
A	A426
A	U427

---

site_id	AD8
Number of Residues	2
Details	binding site for residue MG A 1917

Chain	Residue
A	A679
A	G680

---

site_id	AD9
Number of Residues	1
Details	binding site for residue MG A 1919

Chain	Residue
A	U1025

---

site_id	AE1
Number of Residues	2
Details	binding site for residue MG A 1920

Chain	Residue
A	C676
A	C1026

---

site_id	AE2
Number of Residues	3
Details	binding site for residue MG A 1921

Chain	Residue
A	G601
A	A604
A	A605

---

site_id	AE3
Number of Residues	4
Details	binding site for residue MG A 1922

Chain	Residue
A	U1101
A	G1102
A	G1130
A	G1131

---

site_id	AE4
Number of Residues	2
Details	binding site for residue MG A 1924

Chain	Residue
A	A508
A	OMG509

---

site_id	AE5
Number of Residues	2
Details	binding site for residue MG A 1925

Chain	Residue
A	G1166
A	G1167

---

site_id	AE6
Number of Residues	1
Details	binding site for residue MG A 1926

Chain	Residue
A	A2M27

---

site_id	AE7
Number of Residues	1
Details	binding site for residue MG A 1928

Chain	Residue
A	A653

---

site_id	AE8
Number of Residues	1
Details	binding site for residue MG A 1929

Chain	Residue
A	A672

---

site_id	AE9
Number of Residues	1
Details	binding site for residue MG A 1932

Chain	Residue
A	A1028

---

site_id	AF1
Number of Residues	1
Details	binding site for residue MG A 1933

Chain	Residue
A	U1

---

site_id	AF2
Number of Residues	2
Details	binding site for residue MG A 1934

Chain	Residue
A	A1036
A	U1072

---

site_id	AF3
Number of Residues	1
Details	binding site for residue MG A 1935

Chain	Residue
A	U1839

---

site_id	AF4
Number of Residues	4
Details	binding site for residue MG A 1936

Chain	Residue
A	G90
A	A91
A	A92
A	G446

---

site_id	AF5
Number of Residues	2
Details	binding site for residue MG A 1937

Chain	Residue
A	G385
A	A389

---

site_id	AF6
Number of Residues	2
Details	binding site for residue MG A 1938

Chain	Residue
A	A920
A	G923

---

site_id	AF7
Number of Residues	2
Details	binding site for residue MG A 1940

Chain	Residue
A	A672
A	C674

---

site_id	AF8
Number of Residues	1
Details	binding site for residue MG A 1941

Chain	Residue
A	A1082

---

site_id	AF9
Number of Residues	3
Details	binding site for residue MG A 1942

Chain	Residue
A	A2M668
A	A669
A	A670

---

site_id	AG1
Number of Residues	1
Details	binding site for residue MG A 1943

Chain	Residue
A	A2M668

---

site_id	AG2
Number of Residues	1
Details	binding site for residue MG A 1944

Chain	Residue
A	G1862

---

site_id	AG3
Number of Residues	2
Details	binding site for residue MG A 1945

Chain	Residue
A	G7
A	G16

---

site_id	AG4
Number of Residues	2
Details	binding site for residue MG A 1947

Chain	Residue
A	U59
A	G62

---

site_id	AG5
Number of Residues	3
Details	binding site for residue MG A 1949

Chain	Residue
A	A99
A	U100
A	C409

---

site_id	AG6
Number of Residues	2
Details	binding site for residue MG A 1950

Chain	Residue
A	A173
A	OMC174

---

site_id	AG7
Number of Residues	1
Details	binding site for residue MG A 1952

Chain	Residue
A	G477

---

site_id	AG8
Number of Residues	4
Details	binding site for residue MG A 1953

Chain	Residue
A	C492
A	U495
A	C496
A	G506

---

site_id	AG9
Number of Residues	1
Details	binding site for residue MG A 1954

Chain	Residue
A	A564

---

site_id	AH1
Number of Residues	2
Details	binding site for residue MG A 1955

Chain	Residue
A	C593
A	A594

---

site_id	AH2
Number of Residues	3
Details	binding site for residue MG A 1956

Chain	Residue
A	G684
A	A685
A	A864

---

site_id	AH3
Number of Residues	2
Details	binding site for residue MG A 1957

Chain	Residue
A	G985
A	G986

---

site_id	AH4
Number of Residues	3
Details	binding site for residue MG A 1958

Chain	Residue
A	U1186
A	U1174
A	G1175

---

site_id	AH5
Number of Residues	10
Details	binding site for residues PSU A 822 and PSU A 823

Chain	Residue
A	G821
A	C824
A	A825
A	A826
A	A827
D	GLN140
D	VAL141
D	VAL142
D	ASN143
T	PHE64

---

site_id	AH6
Number of Residues	13
Details	binding site for residues MA6 A 1850 and MA6 A 1851

Chain	Residue
9	MET1
9	ARG9
A	C1705
A	G1706
A	U1707
A	G1829
A	UR31830
A	A1831
A	U1848
A	G1849
A	C1852
p	LYS65
p	ASN70

---

Functional Information from PROSITE/UniProt

site_id	PS00053
Number of Residues	18
Details	RIBOSOMAL_S8 Ribosomal protein S8 signature. GfiVLTTSaGIMdheeAR

Chain	Residue	Details
J	GLY100-ARG117

---

site_id	PS00054
Number of Residues	23
Details	RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GMkIgrieDvTPiPSD

Chain	Residue	Details
P	LEU116-ASP138

---

site_id	PS00055
Number of Residues	8
Details	RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR

Chain	Residue	Details
E	LYS60-ARG67

---

site_id	PS00056
Number of Residues	13
Details	RIBOSOMAL_S17 Ribosomal protein S17 signature. GDiVtVgEcRPLS

Chain	Residue	Details
B	GLY123-SER135

---

site_id	PS00362
Number of Residues	31
Details	RIBOSOMAL_S15 Ribosomal protein S15 signature. VrkHLernRkDkdAkfrLilIesrihrLarY

Chain	Residue	Details
I	VAL98-TYR128

---

site_id	PS00528
Number of Residues	15
Details	RIBOSOMAL_S4E Ribosomal protein S4e signature. HlKRVAaPkhWmLdK

Chain	Residue	Details
C	HIS8-LYS22

---

site_id	PS00529
Number of Residues	23
Details	RIBOSOMAL_S24E Ribosomal protein S24e signature. FGggKTtGFGmIYDSldyakknE

Chain	Residue	Details
T	PHE64-GLU86

---

site_id	PS00578
Number of Residues	12
Details	RIBOSOMAL_S6E Ribosomal protein S6e signature. ISGGnDkqGfPM

Chain	Residue	Details
S	ILE52-MET63

---

site_id	PS00585
Number of Residues	33
Details	RIBOSOMAL_S5 Ribosomal protein S5 signature. GQrtrFkAfvAIGDyn.GhVGlGvkcsk.EVat.AI

Chain	Residue	Details
L	GLY119-ILE151

---

site_id	PS00632
Number of Residues	25
Details	RIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtqVFKlglAkSihhARvLI

Chain	Residue	Details
D	LEU106-ILE130

---

site_id	PS00712
Number of Residues	16
Details	RIBOSOMAL_S17E Ribosomal protein S17e signature. IpSKkLRNkIAGYvTH

Chain	Residue	Details
M	ILE41-HIS56

---

site_id	PS00733
Number of Residues	8
Details	RIBOSOMAL_S26E Ribosomal protein S26e signature. YCVSCAIH

Chain	Residue	Details
Q	TYR73-HIS80

---

site_id	PS00948
Number of Residues	14
Details	RIBOSOMAL_S7E Ribosomal protein S7e signature. RLvRELEKKFSgKH

Chain	Residue	Details
G	ARG78-HIS91

---

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. VlKFLAAGTHLG

Chain	Residue	Details
N	VAL15-GLY26

---

site_id	PS00963
Number of Residues	25
Details	RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrlLVVtDpraDhqpLtEasyvNLP

Chain	Residue	Details
N	PRO119-PRO143

---

site_id	PS00996
Number of Residues	9
Details	RIBOSOMAL_S21E Ribosomal protein S21e signature. LYVPRKCSA

Chain	Residue	Details
K	LEU11-ALA19

---

site_id	PS01168
Number of Residues	33
Details	RIBOSOMAL_S27E Ribosomal protein S27e signature. KCpgCykittvFShAqtvvlCvgCStvLcqPtG

Chain	Residue	Details
H	LYS36-GLY68

---

site_id	PS01191
Number of Residues	13
Details	RIBOSOMAL_S3AE Ribosomal protein S3Ae signature. LkGRVfEvSLaDL

Chain	Residue	Details
O	LEU62-LEU74

---

site_id	PS01193
Number of Residues	20
Details	RIBOSOMAL_S8E Ribosomal protein S8e signature. RrkTGGkrkpy.HkKrKyELG

Chain	Residue	Details
R	ARG11-GLY30

---

site_id	PS01262
Number of Residues	23
Details	IF1A Eukaryotic initiation factor 1A signature. MlGnGRleamCfDGvkRlcHIrG

Chain	Residue	Details
q	MET41-GLY63

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	MOD_RES: Phosphoserine => ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17322308

Chain	Residue	Details
y	SER9
y	SER11
y	SER13
y	SER15
y	SER16
y	SER18
y	SER39
y	SER166
y	SER909

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8R1B4

Chain	Residue	Details
y	LYS99
y	LYS643
H	CYS56
H	CYS59

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8R1B4

Chain	Residue	Details
y	SER178
y	SER181
y	SER182

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17322308

Chain	Residue	Details
y	THR524
G	LYS74
P	LYS63
P	LYS106

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000255|HAMAP-Rule:MF_03009, ECO:0000269|PubMed:17322308, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
z	THR109
B	SER110
R	LYS193

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
z	SER127
I	LYS43

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
z	TYR254

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
z	LYS106
L	LYS275

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
S	SER244
S	SER247

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
S	LYS14

---