6XVF
Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0006508 | biological_process | proteolysis |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| C | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 0031966 | cellular_component | mitochondrial membrane |
| C | 0045275 | cellular_component | respiratory chain complex III |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048039 | molecular_function | ubiquinone binding |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0020037 | molecular_function | heme binding |
| E | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| E | 0016020 | cellular_component | membrane |
| E | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005743 | cellular_component | mitochondrial inner membrane |
| F | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| F | 0045275 | cellular_component | respiratory chain complex III |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005743 | cellular_component | mitochondrial inner membrane |
| G | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| G | 0045275 | cellular_component | respiratory chain complex III |
| H | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| I | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| J | 0005739 | cellular_component | mitochondrion |
| J | 0005743 | cellular_component | mitochondrial inner membrane |
| J | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| J | 0045275 | cellular_component | respiratory chain complex III |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue PG4 A 501 |
| Chain | Residue |
| A | TYR386 |
| A | ARG388 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue 6PE A 502 |
| Chain | Residue |
| A | SER439 |
| A | PHE442 |
| A | LEU444 |
| A | CDL504 |
| C | HIS221 |
| D | LYS226 |
| E | PX4202 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 503 |
| Chain | Residue |
| A | ASP332 |
| A | GLN430 |
| A | PRO432 |
| A | ASP433 |
| C | PRO219 |
| G | PHE4 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CDL A 504 |
| Chain | Residue |
| A | TRP443 |
| A | LEU444 |
| A | ARG445 |
| A | 6PE502 |
| C | ARG5 |
| C | ILE19 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 501 |
| Chain | Residue |
| A | SER291 |
| B | ARG87 |
| F | ALA108 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue HEM C 401 |
| Chain | Residue |
| C | GLN44 |
| C | GLY48 |
| C | LEU49 |
| C | LEU51 |
| C | ARG80 |
| C | HIS83 |
| C | ALA87 |
| C | PHE90 |
| C | THR126 |
| C | GLY130 |
| C | LEU133 |
| C | PRO134 |
| C | HIS182 |
| C | PHE183 |
| C | PRO186 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | binding site for residue HEM C 402 |
| Chain | Residue |
| C | TRP31 |
| C | GLY34 |
| C | LEU37 |
| C | HIS97 |
| C | VAL98 |
| C | ARG100 |
| C | SER106 |
| C | TRP113 |
| C | GLY116 |
| C | LEU120 |
| C | HIS196 |
| C | LEU197 |
| C | LEU200 |
| C | SER205 |
| C | ASN206 |
| C | JAG408 |
| C | HOH501 |
| C | HOH502 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue LMT C 403 |
| Chain | Residue |
| C | THR349 |
| C | GLN352 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue PG4 C 404 |
| Chain | Residue |
| C | ILE146 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue PG4 C 405 |
| Chain | Residue |
| C | PHE128 |
| C | LEU150 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue CDL C 406 |
| Chain | Residue |
| C | SER28 |
| C | SER29 |
| C | TRP30 |
| C | PEE407 |
| D | CDL503 |
| F | GLN72 |
| G | ARG40 |
| G | THR41 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue PEE C 407 |
| Chain | Residue |
| C | TRP30 |
| C | TYR95 |
| C | TYR103 |
| C | TYR104 |
| C | MET316 |
| C | PHE325 |
| C | TRP326 |
| C | CDL406 |
| F | GLN72 |
| G | CYS44 |
| G | VAL48 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for residue JAG C 408 |
| Chain | Residue |
| C | ALA17 |
| C | LEU21 |
| C | SER35 |
| C | GLY38 |
| C | MET190 |
| C | MET194 |
| C | HIS201 |
| C | SER205 |
| C | PHE220 |
| C | ASP228 |
| C | HEM402 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 C 409 |
| Chain | Residue |
| C | GLY167 |
| C | PHE168 |
| E | VAL68 |
| E | MET71 |
| E | ARG92 |
| site_id | AD6 |
| Number of Residues | 13 |
| Details | binding site for residue HEC D 501 |
| Chain | Residue |
| D | CYS40 |
| D | HIS41 |
| D | ASN105 |
| D | PRO111 |
| D | ILE116 |
| D | ARG120 |
| D | TYR126 |
| D | PHE153 |
| D | GLY159 |
| D | MET160 |
| D | PRO163 |
| D | VAL32 |
| D | CYS37 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 D 502 |
| Chain | Residue |
| D | GLU124 |
| D | ARG191 |
| site_id | AD8 |
| Number of Residues | 13 |
| Details | binding site for residue CDL D 503 |
| Chain | Residue |
| C | SER29 |
| C | LYS227 |
| C | CDL406 |
| D | TYR220 |
| D | LYS223 |
| D | ARG224 |
| D | LYS231 |
| F | ARG71 |
| G | TYR29 |
| G | ILE34 |
| G | ASN36 |
| G | VAL37 |
| G | ARG40 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue FES E 201 |
| Chain | Residue |
| E | CYS139 |
| E | HIS141 |
| E | CYS158 |
| E | CYS160 |
| E | HIS161 |
| E | SER163 |
| site_id | AE1 |
| Number of Residues | 12 |
| Details | binding site for residue PX4 E 202 |
| Chain | Residue |
| A | ASP417 |
| A | PHE442 |
| A | LEU444 |
| A | 6PE502 |
| D | MET222 |
| E | TYR37 |
| E | THR40 |
| E | THR44 |
| J | PHE14 |
| J | ARG15 |
| J | THR17 |
| J | PHE20 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 E 203 |
| Chain | Residue |
| E | ARG15 |
| E | PRO16 |
| E | GLU17 |
| G | ARG24 |
| G | PO4101 |
| site_id | AE3 |
| Number of Residues | 9 |
| Details | binding site for residue PEE E 204 |
| Chain | Residue |
| C | ILE78 |
| D | HIS200 |
| D | MET204 |
| D | LYS207 |
| D | MET208 |
| E | TYR49 |
| E | ASN53 |
| E | GLN57 |
| J | ASP36 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue CDL E 205 |
| Chain | Residue |
| C | ASN159 |
| E | LYS52 |
| E | SER56 |
| E | VAL59 |
| E | SER63 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 F 501 |
| Chain | Residue |
| B | ARG134 |
| F | TYR93 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 G 101 |
| Chain | Residue |
| E | PO4203 |
| G | ARG24 |
| G | ALA25 |
| G | PHE26 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 G 102 |
| Chain | Residue |
| G | HIS28 |
| G | TYR29 |
| G | PHE30 |
| G | SER31 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 G 103 |
| Chain | Residue |
| G | ALA43 |
| G | LEU46 |
| G | ARG47 |
Functional Information from PROSITE/UniProt
| site_id | PS00143 |
| Number of Residues | 24 |
| Details | INSULINASE Insulinase family, zinc-binding region signature. GsryensnnlGtSHLLRLAsSlTT |
| Chain | Residue | Details |
| B | GLY54-THR77 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:9651245 |
| Chain | Residue | Details |
| J | PHE20-HIS45 | |
| H | LYS72 | |
| F | LYS95 | |
| C | PHE178-LEU198 | |
| C | ILE226-ALA246 | |
| C | LEU288-HIS308 | |
| C | LEU320-GLY340 | |
| C | TYR347-PRO367 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9CQ69 |
| Chain | Residue | Details |
| G | LYS32 | |
| F | LYS87 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 133 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:9651245 |
| Chain | Residue | Details |
| E | SER63-GLY196 | |
| C | HIS196 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9651245, ECO:0007744|PDB:1BE3, ECO:0007744|PDB:1BGY |
| Chain | Residue | Details |
| E | CYS139 | |
| E | HIS141 | |
| E | CYS158 | |
| E | HIS161 | |
| E | SER163 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15312779, ECO:0000269|PubMed:16024040, ECO:0007744|PDB:1PP9, ECO:0007744|PDB:1SQV, ECO:0007744|PDB:2A06, ECO:0007744|PDB:2YBB |
| Chain | Residue | Details |
| C | HIS201 |
