6XUP
Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 501 |
| Chain | Residue |
| A | GLN159 |
| A | ARG380 |
| A | LEU427 |
| R | DA1 |
| R | DC3 |
| R | HOH104 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | ASN413 |
| A | HOH607 |
| A | HOH815 |
| A | ASN132 |
| A | PRO411 |
| A | ILE412 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 503 |
| Chain | Residue |
| A | ASN146 |
| A | SER282 |
| A | ARG283 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue BME A 504 |
| Chain | Residue |
| A | GLY206 |
| A | THR207 |
| A | MET208 |
| A | MET377 |
| A | TRP379 |
| A | TYR393 |
| A | HOH792 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue BME A 505 |
| Chain | Residue |
| A | TYR225 |
| A | SER228 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue BME A 507 |
| Chain | Residue |
| A | ILE104 |
| B | HIS79 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue BME A 508 |
| Chain | Residue |
| A | SER228 |
| A | LYS231 |
| A | LYS232 |
| A | HOH719 |
| A | HOH720 |
| A | HOH783 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue BME A 509 |
| Chain | Residue |
| A | SER214 |
| A | PRO215 |
| A | ILE401 |
| A | PRO411 |
| A | ILE412 |
| A | HOH653 |
| A | HOH677 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 510 |
| Chain | Residue |
| B | LEU324 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 511 |
| Chain | Residue |
| A | ASN35 |
| A | TYR36 |
| A | ILE216 |
| A | ASN405 |
| A | HOH653 |
| A | HOH718 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 512 |
| Chain | Residue |
| A | HOH615 |
| B | PRO42 |
| B | SER43 |
| B | LEU44 |
| B | ASN47 |
| B | HIS79 |
| B | HOH611 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 513 |
| Chain | Residue |
| A | ILE131 |
| A | ASN132 |
| A | SER133 |
| A | ILE134 |
| A | ASN417 |
| A | SER419 |
| A | HOH622 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 514 |
| Chain | Residue |
| A | ASP180 |
| A | LYS204 |
| A | TRP244 |
| A | ASP245 |
| A | HOH770 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue CAC A 515 |
| Chain | Residue |
| A | GLY408 |
| A | HOH601 |
| B | LYS45 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue K A 516 |
| Chain | Residue |
| A | ASN54 |
| A | TYR88 |
| A | VAL114 |
| A | LEU115 |
| A | PRO116 |
| A | HOH640 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 501 |
| Chain | Residue |
| B | GLN159 |
| B | LEU427 |
| P | DA1 |
| P | DC3 |
| P | HOH103 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue BME B 502 |
| Chain | Residue |
| B | ASN35 |
| B | ILE216 |
| B | ASN405 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | ILE213 |
| B | SER214 |
| B | ILE216 |
| B | ILE401 |
| B | PRO411 |
| B | ILE412 |
| B | HOH618 |
| B | HOH662 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | LYS127 |
| B | LEU396 |
| B | PHE426 |
| P | HOH103 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue CAC B 505 |
| Chain | Residue |
| A | LYS45 |
| B | GLY408 |
| B | GLY409 |
| B | TYR410 |
| B | HOH628 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 258 |
| Details | Region: {"description":"Mid domain","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33633170","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Region: {"description":"Binds 5'-phosphorylated end of guide DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Region: {"description":"Binds target DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Region: {"description":"Binds guide DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1YTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
