6XRE

Structure of the p53/RNA polymerase II assembly

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0000974	cellular_component	Prp19 complex
A	0001172	biological_process	RNA-templated transcription
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005665	cellular_component	RNA polymerase II, core complex
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0006353	biological_process	DNA-templated transcription termination
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0008270	molecular_function	zinc ion binding
A	0010628	biological_process	positive regulation of gene expression
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0019900	molecular_function	kinase binding
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0033120	biological_process	positive regulation of RNA splicing
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0042789	biological_process	mRNA transcription by RNA polymerase II
A	0046872	molecular_function	metal ion binding
A	0050436	molecular_function	microfibril binding
A	1990841	molecular_function	promoter-specific chromatin binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0000781	cellular_component	chromosome, telomeric region
B	0001172	biological_process	RNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003723	molecular_function	RNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005665	cellular_component	RNA polymerase II, core complex
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0008270	molecular_function	zinc ion binding
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005665	cellular_component	RNA polymerase II, core complex
D	0005829	cellular_component	cytosol
D	0006352	biological_process	DNA-templated transcription initiation
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0016607	cellular_component	nuclear speck
D	0030880	cellular_component	RNA polymerase complex
D	0031369	molecular_function	translation initiation factor binding
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005730	cellular_component	nucleolus
E	0005736	cellular_component	RNA polymerase I complex
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
E	0050821	biological_process	protein stabilization
E	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005730	cellular_component	nucleolus
F	0005736	cellular_component	RNA polymerase I complex
F	0005829	cellular_component	cytosol
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0000932	cellular_component	P-body
G	0000956	biological_process	nuclear-transcribed mRNA catabolic process
G	0003676	molecular_function	nucleic acid binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003723	molecular_function	RNA binding
G	0003727	molecular_function	single-stranded RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005665	cellular_component	RNA polymerase II, core complex
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0031369	molecular_function	translation initiation factor binding
G	0045948	biological_process	positive regulation of translational initiation
G	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003677	molecular_function	DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005730	cellular_component	nucleolus
H	0005736	cellular_component	RNA polymerase I complex
H	0005829	cellular_component	cytosol
H	0006351	biological_process	DNA-templated transcription
H	0006366	biological_process	transcription by RNA polymerase II
H	0032993	cellular_component	protein-DNA complex
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005730	cellular_component	nucleolus
J	0005736	cellular_component	RNA polymerase I complex
J	0005829	cellular_component	cytosol
J	0006351	biological_process	DNA-templated transcription
J	0006356	biological_process	regulation of transcription by RNA polymerase I
J	0006360	biological_process	transcription by RNA polymerase I
J	0006366	biological_process	transcription by RNA polymerase II
J	0008270	molecular_function	zinc ion binding
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0030275	molecular_function	LRR domain binding
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0005829	cellular_component	cytosol
L	0006351	biological_process	DNA-templated transcription
L	0006356	biological_process	regulation of transcription by RNA polymerase I
L	0006366	biological_process	transcription by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0000122	biological_process	negative regulation of transcription by RNA polymerase II
M	0000423	biological_process	mitophagy
M	0000785	cellular_component	chromatin
M	0000976	molecular_function	transcription cis-regulatory region binding
M	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
M	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
M	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
M	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
M	0001046	molecular_function	core promoter sequence-specific DNA binding
M	0001094	molecular_function	TFIID-class transcription factor complex binding
M	0001223	molecular_function	transcription coactivator binding
M	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
M	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
M	0001701	biological_process	in utero embryonic development
M	0001756	biological_process	somitogenesis
M	0001836	biological_process	release of cytochrome c from mitochondria
M	0002020	molecular_function	protease binding
M	0002039	molecular_function	p53 binding
M	0002244	biological_process	hematopoietic progenitor cell differentiation
M	0002309	biological_process	T cell proliferation involved in immune response
M	0002326	biological_process	B cell lineage commitment
M	0002360	biological_process	T cell lineage commitment
M	0002931	biological_process	response to ischemia
M	0003677	molecular_function	DNA binding
M	0003682	molecular_function	chromatin binding
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0003730	molecular_function	mRNA 3'-UTR binding
M	0005507	molecular_function	copper ion binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005657	cellular_component	replication fork
M	0005667	cellular_component	transcription regulator complex
M	0005730	cellular_component	nucleolus
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005759	cellular_component	mitochondrial matrix
M	0005783	cellular_component	endoplasmic reticulum
M	0005813	cellular_component	centrosome
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0006289	biological_process	nucleotide-excision repair
M	0006302	biological_process	double-strand break repair
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0006606	biological_process	protein import into nucleus
M	0006914	biological_process	autophagy
M	0006915	biological_process	apoptotic process
M	0006974	biological_process	DNA damage response
M	0006979	biological_process	response to oxidative stress
M	0006983	biological_process	ER overload response
M	0007179	biological_process	transforming growth factor beta receptor signaling pathway
M	0007265	biological_process	Ras protein signal transduction
M	0007346	biological_process	regulation of mitotic cell cycle
M	0007369	biological_process	gastrulation
M	0007405	biological_process	neuroblast proliferation
M	0007406	biological_process	negative regulation of neuroblast proliferation
M	0007417	biological_process	central nervous system development
M	0007507	biological_process	heart development
M	0007623	biological_process	circadian rhythm
M	0008104	biological_process	protein localization
M	0008156	biological_process	negative regulation of DNA replication
M	0008270	molecular_function	zinc ion binding
M	0008283	biological_process	cell population proliferation
M	0008285	biological_process	negative regulation of cell population proliferation
M	0008340	biological_process	determination of adult lifespan
M	0009299	biological_process	mRNA transcription
M	0009303	biological_process	rRNA transcription
M	0009410	biological_process	response to xenobiotic stimulus
M	0009411	biological_process	response to UV
M	0009651	biological_process	response to salt stress
M	0009792	biological_process	embryo development ending in birth or egg hatching
M	0010165	biological_process	response to X-ray
M	0010212	biological_process	response to ionizing radiation
M	0010332	biological_process	response to gamma radiation
M	0010628	biological_process	positive regulation of gene expression
M	0010629	biological_process	negative regulation of gene expression
M	0010659	biological_process	cardiac muscle cell apoptotic process
M	0010666	biological_process	positive regulation of cardiac muscle cell apoptotic process
M	0012501	biological_process	programmed cell death
M	0014009	biological_process	glial cell proliferation
M	0016032	biological_process	viral process
M	0016363	cellular_component	nuclear matrix
M	0016604	cellular_component	nuclear body
M	0016605	cellular_component	PML body
M	0017053	cellular_component	transcription repressor complex
M	0019661	biological_process	glucose catabolic process to lactate via pyruvate
M	0019899	molecular_function	enzyme binding
M	0021549	biological_process	cerebellum development
M	0030308	biological_process	negative regulation of cell growth
M	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
M	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
M	0030971	molecular_function	receptor tyrosine kinase binding
M	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0032211	biological_process	negative regulation of telomere maintenance via telomerase
M	0032991	cellular_component	protein-containing complex
M	0033077	biological_process	T cell differentiation in thymus
M	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
M	0033554	biological_process	cellular response to stress
M	0034103	biological_process	regulation of tissue remodeling
M	0034644	biological_process	cellular response to UV
M	0035033	molecular_function	histone deacetylase regulator activity
M	0035264	biological_process	multicellular organism growth
M	0035794	biological_process	positive regulation of mitochondrial membrane permeability
M	0035861	cellular_component	site of double-strand break
M	0036310	molecular_function	ATP-dependent DNA/DNA annealing activity
M	0042127	biological_process	regulation of cell population proliferation
M	0042149	biological_process	cellular response to glucose starvation
M	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
M	0042802	molecular_function	identical protein binding
M	0042826	molecular_function	histone deacetylase binding
M	0042981	biological_process	regulation of apoptotic process
M	0043065	biological_process	positive regulation of apoptotic process
M	0043066	biological_process	negative regulation of apoptotic process
M	0043073	cellular_component	germ cell nucleus
M	0043153	biological_process	entrainment of circadian clock by photoperiod
M	0043504	biological_process	mitochondrial DNA repair
M	0043516	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator
M	0043523	biological_process	regulation of neuron apoptotic process
M	0043525	biological_process	positive regulation of neuron apoptotic process
M	0043621	molecular_function	obsolete protein self-association
M	0045815	biological_process	transcription initiation-coupled chromatin remodeling
M	0045861	biological_process	negative regulation of proteolysis
M	0045892	biological_process	negative regulation of DNA-templated transcription
M	0045893	biological_process	positive regulation of DNA-templated transcription
M	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
M	0045930	biological_process	negative regulation of mitotic cell cycle
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0046677	biological_process	response to antibiotic
M	0046872	molecular_function	metal ion binding
M	0046982	molecular_function	protein heterodimerization activity
M	0048144	biological_process	fibroblast proliferation
M	0048147	biological_process	negative regulation of fibroblast proliferation
M	0048511	biological_process	rhythmic process
M	0048512	biological_process	circadian behavior
M	0048539	biological_process	bone marrow development
M	0048568	biological_process	embryonic organ development
M	0050821	biological_process	protein stabilization
M	0051053	biological_process	negative regulation of DNA metabolic process
M	0051087	molecular_function	protein-folding chaperone binding
M	0051097	biological_process	negative regulation of helicase activity
M	0051262	biological_process	protein tetramerization
M	0051276	biological_process	chromosome organization
M	0051402	biological_process	neuron apoptotic process
M	0051721	molecular_function	protein phosphatase 2A binding
M	0051726	biological_process	regulation of cell cycle
M	0060218	biological_process	hematopoietic stem cell differentiation
M	0060253	biological_process	negative regulation of glial cell proliferation
M	0060333	biological_process	type II interferon-mediated signaling pathway
M	0060411	biological_process	cardiac septum morphogenesis
M	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
M	0062100	biological_process	positive regulation of programmed necrotic cell death
M	0065003	biological_process	protein-containing complex assembly
M	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
M	0070242	biological_process	thymocyte apoptotic process
M	0070243	biological_process	regulation of thymocyte apoptotic process
M	0070245	biological_process	positive regulation of thymocyte apoptotic process
M	0070266	biological_process	necroptotic process
M	0071456	biological_process	cellular response to hypoxia
M	0071466	biological_process	cellular response to xenobiotic stimulus
M	0071479	biological_process	cellular response to ionizing radiation
M	0071480	biological_process	cellular response to gamma radiation
M	0071494	biological_process	cellular response to UV-C
M	0071889	molecular_function	14-3-3 protein binding
M	0072089	biological_process	stem cell proliferation
M	0072331	biological_process	signal transduction by p53 class mediator
M	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
M	0072593	biological_process	reactive oxygen species metabolic process
M	0072717	biological_process	cellular response to actinomycin D
M	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
M	0090398	biological_process	cellular senescence
M	0090399	biological_process	replicative senescence
M	0090403	biological_process	oxidative stress-induced premature senescence
M	0097190	biological_process	apoptotic signaling pathway
M	0097193	biological_process	intrinsic apoptotic signaling pathway
M	0097252	biological_process	oligodendrocyte apoptotic process
M	0097371	molecular_function	MDM2/MDM4 family protein binding
M	0097718	molecular_function	disordered domain specific binding
M	0140296	molecular_function	general transcription initiation factor binding
M	0140677	molecular_function	molecular function activator activity
M	0140693	molecular_function	molecular condensate scaffold activity
M	1900119	biological_process	positive regulation of execution phase of apoptosis
M	1901525	biological_process	negative regulation of mitophagy
M	1902108	biological_process	regulation of mitochondrial membrane permeability involved in apoptotic process
M	1902253	biological_process	regulation of intrinsic apoptotic signaling pathway by p53 class mediator
M	1902749	biological_process	regulation of cell cycle G2/M phase transition
M	1902895	biological_process	positive regulation of miRNA transcription
M	1903451	biological_process	negative regulation of G1 to G0 transition
M	1903799	biological_process	negative regulation of miRNA processing
M	1904024	biological_process	negative regulation of glucose catabolic process to lactate via pyruvate
M	1905856	biological_process	negative regulation of pentose-phosphate shunt
M	1990144	biological_process	intrinsic apoptotic signaling pathway in response to hypoxia
M	1990841	molecular_function	promoter-specific chromatin binding
M	2000269	biological_process	regulation of fibroblast apoptotic process
M	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
M	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
M	2000647	biological_process	negative regulation of stem cell proliferation
M	2000772	biological_process	regulation of cellular senescence
M	2000774	biological_process	positive regulation of cellular senescence
M	2001242	biological_process	regulation of intrinsic apoptotic signaling pathway
M	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG A 2001

Chain	Residue
A	ASP495
A	ASP497
A	ASP499

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site_id	AC2
Number of Residues	3
Details	binding site for residue ZN A 2002

Chain	Residue
A	PRO82
A	GLY83
B	MET1125

---

site_id	AC3
Number of Residues	3
Details	binding site for residue ZN A 2003

Chain	Residue
A	PHE112
A	TYR187
A	GLU211

---

site_id	AC4
Number of Residues	2
Details	binding site for residue ZN A 2004

Chain	Residue
A	GLU30
B	CYS1122

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 1201

Chain	Residue
B	GLU959
B	GLY960
C	ALA180
J	CYS10

---

site_id	AC6
Number of Residues	1
Details	binding site for residue ZN C 301

Chain	Residue
C	THR89

---

site_id	AC7
Number of Residues	2
Details	binding site for residue ZN I 201

Chain	Residue
I	ARG40
I	ASN41

---

site_id	AC8
Number of Residues	3
Details	binding site for residue ZN I 202

Chain	Residue
I	HIS91
I	LYS92
I	CYS114

---

site_id	AC9
Number of Residues	2
Details	binding site for residue ZN L 101

Chain	Residue
L	CYS36
L	CYS39

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPNDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1615-SER1621
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1622-SER1628
A	TYR1825-SER1831
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1916-LYS1922
A	TYR1629-ASN1635
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

---

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCMGGMNRR

Chain	Residue	Details
M	MET237-ARG249

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

---

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
I	CYS86-TRP123

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	ZN_FING: C4-type => ECO:0000255

Chain	Residue	Details
I	CYS17-CYS42
C	CYS90
C	CYS94
C	CYS97
A	ASP499
A	ARG1416
A	ARG1421

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	ZN_FING: TFIIS-type => ECO:0000255|PROSITE-ProRule:PRU00472

Chain	Residue	Details
I	GLU82-THR124
A	ASP495
B	ASP792
M	CYS238
M	CYS242
A	CYS111
A	CYS114
A	CYS154
A	CYS184
A	ASN493

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10145, ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IY6

Chain	Residue	Details
I	CYS17
I	CYS20
I	CYS39
I	CYS42
B	LYS942
B	ARG1078
B	ARG1085

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00472, ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IY6

Chain	Residue	Details
I	CYS86
I	CYS89
I	CYS114
I	CYS119

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
I	MET1
A	SER217
A	SER1868

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-methyllysine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
B	LYS1052

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CHEK2, CK1 and PLK3 => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:20041275

Chain	Residue	Details
M	SER20

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK5 and CDK7 => ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:9372954

Chain	Residue	Details
M	SER33

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000269|PubMed:17254968

Chain	Residue	Details
M	SER37
A	THR1933
A	THR1863
A	THR1870
A	THR1877
A	THR1912
A	THR1915
A	THR1919
A	THR1926
A	THR1929

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG => ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11780126, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:17591690

Chain	Residue	Details
M	SER46

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by TAF1 and GRK5 => ECO:0000269|PubMed:15053879, ECO:0000269|PubMed:20124405

Chain	Residue	Details
M	THR55
A	SER1857
A	SER1861
A	SER1875

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: N6-lactoyllysine => ECO:0000269|PubMed:38653238

Chain	Residue	Details
M	LYS120
M	LYS139

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462

Chain	Residue	Details
M	SER183
M	SER269

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462

Chain	Residue	Details
M	THR284
A	SER1864

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:12724314

Chain	Residue	Details
M	LYS305

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AURKA, CDK1 and CDK2 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:14702041

Chain	Residue	Details
M	SER315
A	LYS1866
A	LYS1873
A	LYS1887

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P02340

Chain	Residue	Details
M	LYS321
A	TYR1867
A	TYR1881
A	TYR1916
A	TYR1930

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:19011621

Chain	Residue	Details
M	ARG333

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5 => ECO:0000269|PubMed:19011621

Chain	Residue	Details
M	ARG335
M	ARG337

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	MOD_RES: N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287

Chain	Residue	Details
M	LYS370

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	MOD_RES: N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881

Chain	Residue	Details
M	LYS372

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795

Chain	Residue	Details
M	LYS373

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29474172, ECO:0007744|PubMed:19608861

Chain	Residue	Details
M	LYS381

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	MOD_RES: N6-methyllysine; by KMT5A; alternate => ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:20870725, ECO:0000269|PubMed:22864287

Chain	Residue	Details
M	LYS382

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CK2, CDK2 and NUAK1 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:35618207

Chain	Residue	Details
M	SER392

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21597459

Chain	Residue	Details
M	LYS24
A	TYR1923

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:11124955, ECO:0000269|PubMed:22214662, ECO:0000269|Ref.37

Chain	Residue	Details
A	SER1913
M	LYS386
A	SER1927

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131

Chain	Residue	Details
M	LYS291
M	LYS292

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19033443

Chain	Residue	Details
M	LYS351
M	LYS357

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1934

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); by NEDD4 => ECO:0000269|PubMed:32142649, ECO:0000305|PubMed:32142654

Chain	Residue	Details
A	LYS1268

---