6XQO

Structure of the human MICU1-MICU2 heterodimer, calcium bound, in association with a lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0005509	molecular_function	calcium ion binding
I	0006851	biological_process	mitochondrial calcium ion transmembrane transport
J	0005509	molecular_function	calcium ion binding
J	0006851	biological_process	mitochondrial calcium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA I 501

Chain	Residue
I	ASP231
I	ASN233
I	ASP235
I	GLU237
I	GLU242

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA I 502

Chain	Residue
I	GLU432
I	ASP421
I	ASP423
I	ASN425
I	GLU427

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA J 501

Chain	Residue
J	ASP185
J	ASP187
J	ASN189
J	MET191
J	GLU196

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA J 502

Chain	Residue
J	ASP375
J	ASP377
J	ASP379
J	CYS381
J	LEU382
J	GLU386

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DLNGDGEVDmeEF

Chain	Residue	Details
I	ASP231-PHE243
I	ASP421-PHE433

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Region: {"description":"K/R-ring","evidences":[{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VCX5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	35
Details	Domain: {"description":"EF-hand 3; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---