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6XNN

Crystal Structure of Mouse STING CTD complex with SR-717.

Functional Information from GO Data
ChainGOidnamespacecontents
A0002218biological_processactivation of innate immune response
A0032481biological_processpositive regulation of type I interferon production
B0002218biological_processactivation of innate immune response
B0032481biological_processpositive regulation of type I interferon production
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue V67 A 401
ChainResidue
ASER161
AHOH520
BILE234
BARG237
BTHR262
BPRO263
BV67401
ATYR162
AGLY165
ATYR166
AARG237
ASER240
ATHR262
AHOH502
AHOH511

site_idAC2
Number of Residues16
Detailsbinding site for residue V67 B 401
ChainResidue
AARG237
ATHR262
APRO263
AV67401
BSER161
BTYR162
BGLY165
BTYR166
BARG237
BTYR239
BSER240
BGLU259
BTHR262
BHOH503
BHOH506
BHOH523

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:23519410, ECO:0007744|PDB:4KBY
ChainResidueDetails
AGLY165
ATHR262
BGLY165
BTHR262

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:23910378, ECO:0007744|PDB:4LOK
ChainResidueDetails
ATYR166
AARG237
BTYR166
BARG237

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q86WV6
ChainResidueDetails
ASER240
BSER240

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86WV6
ChainResidueDetails
ALYS235
BLYS235

site_idSWS_FT_FI5
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:27637147
ChainResidueDetails
ALYS337
BLYS337

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PDB entries from 2024-11-06

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