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6X93

Interleukin-10 signaling complex with IL-10RA and IL-10RB

Functional Information from GO Data
ChainGOidnamespacecontents
A0001818biological_processnegative regulation of cytokine production
A0001819biological_processpositive regulation of cytokine production
A0001938biological_processpositive regulation of endothelial cell proliferation
A0002237biological_processresponse to molecule of bacterial origin
A0002639biological_processpositive regulation of immunoglobulin production
A0002719biological_processnegative regulation of cytokine production involved in immune response
A0002904biological_processpositive regulation of B cell apoptotic process
A0005125molecular_functioncytokine activity
A0005141molecular_functioninterleukin-10 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006955biological_processimmune response
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0010468biological_processregulation of gene expression
A0010507biological_processnegative regulation of autophagy
A0014823biological_processresponse to activity
A0014854biological_processresponse to inactivity
A0019221biological_processcytokine-mediated signaling pathway
A0030097biological_processhemopoiesis
A0030183biological_processB cell differentiation
A0030595biological_processleukocyte chemotaxis
A0030889biological_processnegative regulation of B cell proliferation
A0032496biological_processresponse to lipopolysaccharide
A0032687biological_processnegative regulation of interferon-alpha production
A0032692biological_processnegative regulation of interleukin-1 production
A0032695biological_processnegative regulation of interleukin-12 production
A0032701biological_processnegative regulation of interleukin-18 production
A0032715biological_processnegative regulation of interleukin-6 production
A0032717biological_processnegative regulation of interleukin-8 production
A0032720biological_processnegative regulation of tumor necrosis factor production
A0032868biological_processresponse to insulin
A0034115biological_processnegative regulation of heterotypic cell-cell adhesion
A0034116biological_processpositive regulation of heterotypic cell-cell adhesion
A0034465biological_processresponse to carbon monoxide
A0042092biological_processtype 2 immune response
A0042100biological_processB cell proliferation
A0042130biological_processnegative regulation of T cell proliferation
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0043032biological_processpositive regulation of macrophage activation
A0043066biological_processnegative regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0045019biological_processnegative regulation of nitric oxide biosynthetic process
A0045063biological_processT-helper 1 cell differentiation
A0045191biological_processregulation of isotype switching
A0045347biological_processnegative regulation of MHC class II biosynthetic process
A0045787biological_processpositive regulation of cell cycle
A0045893biological_processpositive regulation of DNA-templated transcription
A0045930biological_processnegative regulation of mitotic cell cycle
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046983molecular_functionprotein dimerization activity
A0050728biological_processnegative regulation of inflammatory response
A0050807biological_processregulation of synapse organization
A0050864biological_processregulation of B cell activation
A0051045biological_processnegative regulation of membrane protein ectodomain proteolysis
A0051384biological_processresponse to glucocorticoid
A0060302biological_processnegative regulation of cytokine activity
A0071222biological_processcellular response to lipopolysaccharide
A0071392biological_processcellular response to estradiol stimulus
A0071650biological_processnegative regulation of chemokine (C-C motif) ligand 5 production
A0072577biological_processendothelial cell apoptotic process
A0097421biological_processliver regeneration
A0140105biological_processinterleukin-10-mediated signaling pathway
A1900100biological_processpositive regulation of plasma cell differentiation
A1902895biological_processpositive regulation of miRNA transcription
A1903034biological_processregulation of response to wounding
A1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A1903659biological_processregulation of complement-dependent cytotoxicity
A1903672biological_processpositive regulation of sprouting angiogenesis
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A2000352biological_processnegative regulation of endothelial cell apoptotic process
D0001818biological_processnegative regulation of cytokine production
D0001819biological_processpositive regulation of cytokine production
D0001938biological_processpositive regulation of endothelial cell proliferation
D0002237biological_processresponse to molecule of bacterial origin
D0002639biological_processpositive regulation of immunoglobulin production
D0002719biological_processnegative regulation of cytokine production involved in immune response
D0002904biological_processpositive regulation of B cell apoptotic process
D0005125molecular_functioncytokine activity
D0005141molecular_functioninterleukin-10 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006955biological_processimmune response
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0008083molecular_functiongrowth factor activity
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0009410biological_processresponse to xenobiotic stimulus
D0010468biological_processregulation of gene expression
D0010507biological_processnegative regulation of autophagy
D0014823biological_processresponse to activity
D0014854biological_processresponse to inactivity
D0019221biological_processcytokine-mediated signaling pathway
D0030097biological_processhemopoiesis
D0030183biological_processB cell differentiation
D0030595biological_processleukocyte chemotaxis
D0030889biological_processnegative regulation of B cell proliferation
D0032496biological_processresponse to lipopolysaccharide
D0032687biological_processnegative regulation of interferon-alpha production
D0032692biological_processnegative regulation of interleukin-1 production
D0032695biological_processnegative regulation of interleukin-12 production
D0032701biological_processnegative regulation of interleukin-18 production
D0032715biological_processnegative regulation of interleukin-6 production
D0032717biological_processnegative regulation of interleukin-8 production
D0032720biological_processnegative regulation of tumor necrosis factor production
D0032868biological_processresponse to insulin
D0034115biological_processnegative regulation of heterotypic cell-cell adhesion
D0034116biological_processpositive regulation of heterotypic cell-cell adhesion
D0034465biological_processresponse to carbon monoxide
D0042092biological_processtype 2 immune response
D0042100biological_processB cell proliferation
D0042130biological_processnegative regulation of T cell proliferation
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0043032biological_processpositive regulation of macrophage activation
D0043066biological_processnegative regulation of apoptotic process
D0043524biological_processnegative regulation of neuron apoptotic process
D0045019biological_processnegative regulation of nitric oxide biosynthetic process
D0045063biological_processT-helper 1 cell differentiation
D0045191biological_processregulation of isotype switching
D0045347biological_processnegative regulation of MHC class II biosynthetic process
D0045787biological_processpositive regulation of cell cycle
D0045893biological_processpositive regulation of DNA-templated transcription
D0045930biological_processnegative regulation of mitotic cell cycle
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046983molecular_functionprotein dimerization activity
D0050728biological_processnegative regulation of inflammatory response
D0050807biological_processregulation of synapse organization
D0050864biological_processregulation of B cell activation
D0051045biological_processnegative regulation of membrane protein ectodomain proteolysis
D0051384biological_processresponse to glucocorticoid
D0060302biological_processnegative regulation of cytokine activity
D0071222biological_processcellular response to lipopolysaccharide
D0071392biological_processcellular response to estradiol stimulus
D0071650biological_processnegative regulation of chemokine (C-C motif) ligand 5 production
D0072577biological_processendothelial cell apoptotic process
D0097421biological_processliver regeneration
D0140105biological_processinterleukin-10-mediated signaling pathway
D1900100biological_processpositive regulation of plasma cell differentiation
D1902895biological_processpositive regulation of miRNA transcription
D1903034biological_processregulation of response to wounding
D1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
D1903659biological_processregulation of complement-dependent cytotoxicity
D1903672biological_processpositive regulation of sprouting angiogenesis
D1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
D1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
D2000352biological_processnegative regulation of endothelial cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00520
Number of Residues21
DetailsINTERLEUKIN_10 Interleukin-10 family signature. KgylgCQalseMIqFYLeEVM
ChainResidueDetails
ALYS57-MET77

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues17
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues176
DetailsDomain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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