6X91

Crystal structure of MBP-fused human APOBEC1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0006629	biological_process	lipid metabolic process
A	0006641	biological_process	triglyceride metabolic process
A	0006974	biological_process	DNA damage response
A	0008270	molecular_function	zinc ion binding
A	0008643	biological_process	carbohydrate transport
A	0010332	biological_process	response to gamma radiation
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0016554	biological_process	cytidine to uridine editing
A	0016556	biological_process	mRNA modification
A	0016787	molecular_function	hydrolase activity
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0030895	cellular_component	apolipoprotein B mRNA editing enzyme complex
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
A	0042127	biological_process	regulation of cell population proliferation
A	0042157	biological_process	lipoprotein metabolic process
A	0042158	biological_process	lipoprotein biosynthetic process
A	0042597	cellular_component	periplasmic space
A	0042953	biological_process	lipoprotein transport
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
A	0045293	cellular_component	mRNA editing complex
A	0046872	molecular_function	metal ion binding
A	0048255	biological_process	mRNA stabilization
A	0051649	biological_process	establishment of localization in cell
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	0090209	biological_process	negative regulation of triglyceride metabolic process
A	1901982	molecular_function	maltose binding
A	1990060	cellular_component	maltose transport complex
A	2000623	biological_process	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0004126	molecular_function	cytidine deaminase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006397	biological_process	mRNA processing
B	0006629	biological_process	lipid metabolic process
B	0006641	biological_process	triglyceride metabolic process
B	0006974	biological_process	DNA damage response
B	0008270	molecular_function	zinc ion binding
B	0008643	biological_process	carbohydrate transport
B	0010332	biological_process	response to gamma radiation
B	0015144	molecular_function	carbohydrate transmembrane transporter activity
B	0015768	biological_process	maltose transport
B	0016020	cellular_component	membrane
B	0016554	biological_process	cytidine to uridine editing
B	0016556	biological_process	mRNA modification
B	0016787	molecular_function	hydrolase activity
B	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0030895	cellular_component	apolipoprotein B mRNA editing enzyme complex
B	0034219	biological_process	carbohydrate transmembrane transport
B	0034289	biological_process	detection of maltose stimulus
B	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
B	0042127	biological_process	regulation of cell population proliferation
B	0042157	biological_process	lipoprotein metabolic process
B	0042158	biological_process	lipoprotein biosynthetic process
B	0042597	cellular_component	periplasmic space
B	0042953	biological_process	lipoprotein transport
B	0042956	biological_process	maltodextrin transmembrane transport
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
B	0045293	cellular_component	mRNA editing complex
B	0046872	molecular_function	metal ion binding
B	0048255	biological_process	mRNA stabilization
B	0051649	biological_process	establishment of localization in cell
B	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B	0055085	biological_process	transmembrane transport
B	0060326	biological_process	cell chemotaxis
B	0090209	biological_process	negative regulation of triglyceride metabolic process
B	1901982	molecular_function	maltose binding
B	1990060	cellular_component	maltose transport complex
B	2000623	biological_process	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C	0003723	molecular_function	RNA binding
C	0003824	molecular_function	catalytic activity
C	0004126	molecular_function	cytidine deaminase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0006397	biological_process	mRNA processing
C	0006629	biological_process	lipid metabolic process
C	0006641	biological_process	triglyceride metabolic process
C	0006974	biological_process	DNA damage response
C	0008270	molecular_function	zinc ion binding
C	0008643	biological_process	carbohydrate transport
C	0010332	biological_process	response to gamma radiation
C	0015144	molecular_function	carbohydrate transmembrane transporter activity
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0016554	biological_process	cytidine to uridine editing
C	0016556	biological_process	mRNA modification
C	0016787	molecular_function	hydrolase activity
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0030895	cellular_component	apolipoprotein B mRNA editing enzyme complex
C	0034219	biological_process	carbohydrate transmembrane transport
C	0034289	biological_process	detection of maltose stimulus
C	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
C	0042127	biological_process	regulation of cell population proliferation
C	0042157	biological_process	lipoprotein metabolic process
C	0042158	biological_process	lipoprotein biosynthetic process
C	0042597	cellular_component	periplasmic space
C	0042953	biological_process	lipoprotein transport
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
C	0045293	cellular_component	mRNA editing complex
C	0046872	molecular_function	metal ion binding
C	0048255	biological_process	mRNA stabilization
C	0051649	biological_process	establishment of localization in cell
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0060326	biological_process	cell chemotaxis
C	0090209	biological_process	negative regulation of triglyceride metabolic process
C	1901982	molecular_function	maltose binding
C	1990060	cellular_component	maltose transport complex
C	2000623	biological_process	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
D	0003723	molecular_function	RNA binding
D	0003824	molecular_function	catalytic activity
D	0004126	molecular_function	cytidine deaminase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0006397	biological_process	mRNA processing
D	0006629	biological_process	lipid metabolic process
D	0006641	biological_process	triglyceride metabolic process
D	0006974	biological_process	DNA damage response
D	0008270	molecular_function	zinc ion binding
D	0008643	biological_process	carbohydrate transport
D	0010332	biological_process	response to gamma radiation
D	0015144	molecular_function	carbohydrate transmembrane transporter activity
D	0015768	biological_process	maltose transport
D	0016020	cellular_component	membrane
D	0016554	biological_process	cytidine to uridine editing
D	0016556	biological_process	mRNA modification
D	0016787	molecular_function	hydrolase activity
D	0030288	cellular_component	outer membrane-bounded periplasmic space
D	0030895	cellular_component	apolipoprotein B mRNA editing enzyme complex
D	0034219	biological_process	carbohydrate transmembrane transport
D	0034289	biological_process	detection of maltose stimulus
D	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
D	0042127	biological_process	regulation of cell population proliferation
D	0042157	biological_process	lipoprotein metabolic process
D	0042158	biological_process	lipoprotein biosynthetic process
D	0042597	cellular_component	periplasmic space
D	0042953	biological_process	lipoprotein transport
D	0042956	biological_process	maltodextrin transmembrane transport
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
D	0045293	cellular_component	mRNA editing complex
D	0046872	molecular_function	metal ion binding
D	0048255	biological_process	mRNA stabilization
D	0051649	biological_process	establishment of localization in cell
D	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D	0055085	biological_process	transmembrane transport
D	0060326	biological_process	cell chemotaxis
D	0090209	biological_process	negative regulation of triglyceride metabolic process
D	1901982	molecular_function	maltose binding
D	1990060	cellular_component	maltose transport complex
D	2000623	biological_process	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
E	0003723	molecular_function	RNA binding
E	0003824	molecular_function	catalytic activity
E	0004126	molecular_function	cytidine deaminase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0006397	biological_process	mRNA processing
E	0006629	biological_process	lipid metabolic process
E	0006641	biological_process	triglyceride metabolic process
E	0006974	biological_process	DNA damage response
E	0008270	molecular_function	zinc ion binding
E	0008643	biological_process	carbohydrate transport
E	0010332	biological_process	response to gamma radiation
E	0015144	molecular_function	carbohydrate transmembrane transporter activity
E	0015768	biological_process	maltose transport
E	0016020	cellular_component	membrane
E	0016554	biological_process	cytidine to uridine editing
E	0016556	biological_process	mRNA modification
E	0016787	molecular_function	hydrolase activity
E	0030288	cellular_component	outer membrane-bounded periplasmic space
E	0030895	cellular_component	apolipoprotein B mRNA editing enzyme complex
E	0034219	biological_process	carbohydrate transmembrane transport
E	0034289	biological_process	detection of maltose stimulus
E	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
E	0042127	biological_process	regulation of cell population proliferation
E	0042157	biological_process	lipoprotein metabolic process
E	0042158	biological_process	lipoprotein biosynthetic process
E	0042597	cellular_component	periplasmic space
E	0042953	biological_process	lipoprotein transport
E	0042956	biological_process	maltodextrin transmembrane transport
E	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
E	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
E	0045293	cellular_component	mRNA editing complex
E	0046872	molecular_function	metal ion binding
E	0048255	biological_process	mRNA stabilization
E	0051649	biological_process	establishment of localization in cell
E	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
E	0055085	biological_process	transmembrane transport
E	0060326	biological_process	cell chemotaxis
E	0090209	biological_process	negative regulation of triglyceride metabolic process
E	1901982	molecular_function	maltose binding
E	1990060	cellular_component	maltose transport complex
E	2000623	biological_process	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
F	0003723	molecular_function	RNA binding
F	0003824	molecular_function	catalytic activity
F	0004126	molecular_function	cytidine deaminase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0006397	biological_process	mRNA processing
F	0006629	biological_process	lipid metabolic process
F	0006641	biological_process	triglyceride metabolic process
F	0006974	biological_process	DNA damage response
F	0008270	molecular_function	zinc ion binding
F	0008643	biological_process	carbohydrate transport
F	0010332	biological_process	response to gamma radiation
F	0015144	molecular_function	carbohydrate transmembrane transporter activity
F	0015768	biological_process	maltose transport
F	0016020	cellular_component	membrane
F	0016554	biological_process	cytidine to uridine editing
F	0016556	biological_process	mRNA modification
F	0016787	molecular_function	hydrolase activity
F	0030288	cellular_component	outer membrane-bounded periplasmic space
F	0030895	cellular_component	apolipoprotein B mRNA editing enzyme complex
F	0034219	biological_process	carbohydrate transmembrane transport
F	0034289	biological_process	detection of maltose stimulus
F	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
F	0042127	biological_process	regulation of cell population proliferation
F	0042157	biological_process	lipoprotein metabolic process
F	0042158	biological_process	lipoprotein biosynthetic process
F	0042597	cellular_component	periplasmic space
F	0042953	biological_process	lipoprotein transport
F	0042956	biological_process	maltodextrin transmembrane transport
F	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
F	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
F	0045293	cellular_component	mRNA editing complex
F	0046872	molecular_function	metal ion binding
F	0048255	biological_process	mRNA stabilization
F	0051649	biological_process	establishment of localization in cell
F	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
F	0055085	biological_process	transmembrane transport
F	0060326	biological_process	cell chemotaxis
F	0090209	biological_process	negative regulation of triglyceride metabolic process
F	1901982	molecular_function	maltose binding
F	1990060	cellular_component	maltose transport complex
F	2000623	biological_process	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
G	0003723	molecular_function	RNA binding
G	0003824	molecular_function	catalytic activity
G	0004126	molecular_function	cytidine deaminase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0006397	biological_process	mRNA processing
G	0006629	biological_process	lipid metabolic process
G	0006641	biological_process	triglyceride metabolic process
G	0006974	biological_process	DNA damage response
G	0008270	molecular_function	zinc ion binding
G	0008643	biological_process	carbohydrate transport
G	0010332	biological_process	response to gamma radiation
G	0015144	molecular_function	carbohydrate transmembrane transporter activity
G	0015768	biological_process	maltose transport
G	0016020	cellular_component	membrane
G	0016554	biological_process	cytidine to uridine editing
G	0016556	biological_process	mRNA modification
G	0016787	molecular_function	hydrolase activity
G	0030288	cellular_component	outer membrane-bounded periplasmic space
G	0030895	cellular_component	apolipoprotein B mRNA editing enzyme complex
G	0034219	biological_process	carbohydrate transmembrane transport
G	0034289	biological_process	detection of maltose stimulus
G	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
G	0042127	biological_process	regulation of cell population proliferation
G	0042157	biological_process	lipoprotein metabolic process
G	0042158	biological_process	lipoprotein biosynthetic process
G	0042597	cellular_component	periplasmic space
G	0042953	biological_process	lipoprotein transport
G	0042956	biological_process	maltodextrin transmembrane transport
G	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
G	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
G	0045293	cellular_component	mRNA editing complex
G	0046872	molecular_function	metal ion binding
G	0048255	biological_process	mRNA stabilization
G	0051649	biological_process	establishment of localization in cell
G	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
G	0055085	biological_process	transmembrane transport
G	0060326	biological_process	cell chemotaxis
G	0090209	biological_process	negative regulation of triglyceride metabolic process
G	1901982	molecular_function	maltose binding
G	1990060	cellular_component	maltose transport complex
G	2000623	biological_process	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
H	0003723	molecular_function	RNA binding
H	0003824	molecular_function	catalytic activity
H	0004126	molecular_function	cytidine deaminase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0006397	biological_process	mRNA processing
H	0006629	biological_process	lipid metabolic process
H	0006641	biological_process	triglyceride metabolic process
H	0006974	biological_process	DNA damage response
H	0008270	molecular_function	zinc ion binding
H	0008643	biological_process	carbohydrate transport
H	0010332	biological_process	response to gamma radiation
H	0015144	molecular_function	carbohydrate transmembrane transporter activity
H	0015768	biological_process	maltose transport
H	0016020	cellular_component	membrane
H	0016554	biological_process	cytidine to uridine editing
H	0016556	biological_process	mRNA modification
H	0016787	molecular_function	hydrolase activity
H	0030288	cellular_component	outer membrane-bounded periplasmic space
H	0030895	cellular_component	apolipoprotein B mRNA editing enzyme complex
H	0034219	biological_process	carbohydrate transmembrane transport
H	0034289	biological_process	detection of maltose stimulus
H	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
H	0042127	biological_process	regulation of cell population proliferation
H	0042157	biological_process	lipoprotein metabolic process
H	0042158	biological_process	lipoprotein biosynthetic process
H	0042597	cellular_component	periplasmic space
H	0042953	biological_process	lipoprotein transport
H	0042956	biological_process	maltodextrin transmembrane transport
H	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
H	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
H	0045293	cellular_component	mRNA editing complex
H	0046872	molecular_function	metal ion binding
H	0048255	biological_process	mRNA stabilization
H	0051649	biological_process	establishment of localization in cell
H	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
H	0055085	biological_process	transmembrane transport
H	0060326	biological_process	cell chemotaxis
H	0090209	biological_process	negative regulation of triglyceride metabolic process
H	1901982	molecular_function	maltose binding
H	1990060	cellular_component	maltose transport complex
H	2000623	biological_process	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO108-ASN125

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q9Y235

Chain	Residue	Details
A	ALA1063
B	ALA1063
C	ALA1063
D	ALA1063
E	ALA1063
F	ALA1063
G	ALA1063
H	ALA1063

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9Y235

Chain	Residue	Details
A	HIS1061
D	HIS1061
D	CYS1093
D	CYS1096
E	HIS1061
E	CYS1093
E	CYS1096
F	HIS1061
F	CYS1093
F	CYS1096
G	HIS1061
A	CYS1093
G	CYS1093
G	CYS1096
H	HIS1061
H	CYS1093
H	CYS1096
A	CYS1096
B	HIS1061
B	CYS1093
B	CYS1096
C	HIS1061
C	CYS1093
C	CYS1096

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