Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6X5H

Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001701	biological_process	in utero embryonic development
A	0005515	molecular_function	protein binding
A	0005794	cellular_component	Golgi apparatus
A	0006486	biological_process	obsolete protein glycosylation
A	0006487	biological_process	protein N-linked glycosylation
A	0006491	biological_process	N-glycan processing
A	0007179	biological_process	transforming growth factor beta receptor signaling pathway
A	0007229	biological_process	integrin-mediated signaling pathway
A	0007585	biological_process	respiratory gaseous exchange by respiratory system
A	0008424	molecular_function	glycoprotein 6-alpha-L-fucosyltransferase activity
A	0009312	biological_process	oligosaccharide biosynthetic process
A	0010468	biological_process	regulation of gene expression
A	0010761	biological_process	fibroblast migration
A	0016020	cellular_component	membrane
A	0016477	biological_process	cell migration
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0017124	molecular_function	SH3 domain binding
A	0018279	biological_process	protein N-linked glycosylation via asparagine
A	0019082	biological_process	viral protein processing
A	0032580	cellular_component	Golgi cisterna membrane
A	0036066	biological_process	protein O-linked glycosylation via fucose
A	0036071	biological_process	obsolete N-glycan fucosylation
A	0042355	biological_process	L-fucose catabolic process
A	0043112	biological_process	receptor metabolic process
A	0046368	biological_process	GDP-L-fucose metabolic process
A	0046921	molecular_function	alpha-(1->6)-fucosyltransferase activity
A	0070062	cellular_component	extracellular exosome
A	1900407	biological_process	regulation of cellular response to oxidative stress
B	0000139	cellular_component	Golgi membrane
B	0001701	biological_process	in utero embryonic development
B	0005515	molecular_function	protein binding
B	0005794	cellular_component	Golgi apparatus
B	0006486	biological_process	obsolete protein glycosylation
B	0006487	biological_process	protein N-linked glycosylation
B	0006491	biological_process	N-glycan processing
B	0007179	biological_process	transforming growth factor beta receptor signaling pathway
B	0007229	biological_process	integrin-mediated signaling pathway
B	0007585	biological_process	respiratory gaseous exchange by respiratory system
B	0008424	molecular_function	glycoprotein 6-alpha-L-fucosyltransferase activity
B	0009312	biological_process	oligosaccharide biosynthetic process
B	0010468	biological_process	regulation of gene expression
B	0010761	biological_process	fibroblast migration
B	0016020	cellular_component	membrane
B	0016477	biological_process	cell migration
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0017124	molecular_function	SH3 domain binding
B	0018279	biological_process	protein N-linked glycosylation via asparagine
B	0019082	biological_process	viral protein processing
B	0032580	cellular_component	Golgi cisterna membrane
B	0036066	biological_process	protein O-linked glycosylation via fucose
B	0036071	biological_process	obsolete N-glycan fucosylation
B	0042355	biological_process	L-fucose catabolic process
B	0043112	biological_process	receptor metabolic process
B	0046368	biological_process	GDP-L-fucose metabolic process
B	0046921	molecular_function	alpha-(1->6)-fucosyltransferase activity
B	0070062	cellular_component	extracellular exosome
B	1900407	biological_process	regulation of cellular response to oxidative stress
C	0000139	cellular_component	Golgi membrane
C	0001701	biological_process	in utero embryonic development
C	0005515	molecular_function	protein binding
C	0005794	cellular_component	Golgi apparatus
C	0006486	biological_process	obsolete protein glycosylation
C	0006487	biological_process	protein N-linked glycosylation
C	0006491	biological_process	N-glycan processing
C	0007179	biological_process	transforming growth factor beta receptor signaling pathway
C	0007229	biological_process	integrin-mediated signaling pathway
C	0007585	biological_process	respiratory gaseous exchange by respiratory system
C	0008424	molecular_function	glycoprotein 6-alpha-L-fucosyltransferase activity
C	0009312	biological_process	oligosaccharide biosynthetic process
C	0010468	biological_process	regulation of gene expression
C	0010761	biological_process	fibroblast migration
C	0016020	cellular_component	membrane
C	0016477	biological_process	cell migration
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0017124	molecular_function	SH3 domain binding
C	0018279	biological_process	protein N-linked glycosylation via asparagine
C	0019082	biological_process	viral protein processing
C	0032580	cellular_component	Golgi cisterna membrane
C	0036066	biological_process	protein O-linked glycosylation via fucose
C	0036071	biological_process	obsolete N-glycan fucosylation
C	0042355	biological_process	L-fucose catabolic process
C	0043112	biological_process	receptor metabolic process
C	0046368	biological_process	GDP-L-fucose metabolic process
C	0046921	molecular_function	alpha-(1->6)-fucosyltransferase activity
C	0070062	cellular_component	extracellular exosome
C	1900407	biological_process	regulation of cellular response to oxidative stress
D	0000139	cellular_component	Golgi membrane
D	0001701	biological_process	in utero embryonic development
D	0005515	molecular_function	protein binding
D	0005794	cellular_component	Golgi apparatus
D	0006486	biological_process	obsolete protein glycosylation
D	0006487	biological_process	protein N-linked glycosylation
D	0006491	biological_process	N-glycan processing
D	0007179	biological_process	transforming growth factor beta receptor signaling pathway
D	0007229	biological_process	integrin-mediated signaling pathway
D	0007585	biological_process	respiratory gaseous exchange by respiratory system
D	0008424	molecular_function	glycoprotein 6-alpha-L-fucosyltransferase activity
D	0009312	biological_process	oligosaccharide biosynthetic process
D	0010468	biological_process	regulation of gene expression
D	0010761	biological_process	fibroblast migration
D	0016020	cellular_component	membrane
D	0016477	biological_process	cell migration
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0017124	molecular_function	SH3 domain binding
D	0018279	biological_process	protein N-linked glycosylation via asparagine
D	0019082	biological_process	viral protein processing
D	0032580	cellular_component	Golgi cisterna membrane
D	0036066	biological_process	protein O-linked glycosylation via fucose
D	0036071	biological_process	obsolete N-glycan fucosylation
D	0042355	biological_process	L-fucose catabolic process
D	0043112	biological_process	receptor metabolic process
D	0046368	biological_process	GDP-L-fucose metabolic process
D	0046921	molecular_function	alpha-(1->6)-fucosyltransferase activity
D	0070062	cellular_component	extracellular exosome
D	1900407	biological_process	regulation of cellular response to oxidative stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue GDP A 601

Chain	Residue
A	GLY219
A	THR408
A	ILE432
A	ALA436
A	ARG441
A	GLY449
A	VAL450
A	ASP453
A	SER468
A	SER469
A	GLN470
A	TYR220
A	VAL471
A	HOH710
A	HOH738
A	HOH771
A	HOH788
A	HOH916
A	GLY221
A	CYS222
A	TYR250
A	HIS363
A	ARG365
A	LYS369
A	ALA407

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 602

Chain	Residue
A	PRO568
A	THR569
A	TYR570
A	PRO571
A	HOH728

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 603

Chain	Residue
A	GLU387
A	LYS402
A	TYR421
A	PRO422
A	ASN423

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 604

Chain	Residue
A	ASP429
A	ASN430
A	SER431
A	LYS566
A	HOH851

site_id	AC5
Number of Residues	1
Details	binding site for residue EDO A 605

Chain	Residue
A	HOH957

site_id	AC6
Number of Residues	1
Details	binding site for residue EDO A 606

Chain	Residue
A	HIS483

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 607

Chain	Residue
A	GLY217
A	CYS218
A	ARG249
A	TYR442

site_id	AC8
Number of Residues	26
Details	binding site for residue GDP B 601

Chain	Residue
B	GLY219
B	TYR220
B	GLY221
B	CYS222
B	TYR250
B	HIS363
B	ARG365
B	LYS369
B	ALA407
B	THR408
B	ILE432
B	ALA436
B	ARG441
B	GLY449
B	VAL450
B	ASP453
B	SER468
B	SER469
B	GLN470
B	VAL471
B	HOH704
B	HOH724
B	HOH766
B	HOH849
B	HOH865
B	HOH971

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL B 602

Chain	Residue
B	GLN238
B	PRO568
B	THR569
B	TYR570
B	PRO571
B	HOH728

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO B 603

Chain	Residue
B	GLY217
B	ARG249
B	TYR442

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL B 604

Chain	Residue
B	LYS402
B	LYS420
B	TYR421
B	PRO422
B	ASN423

site_id	AD3
Number of Residues	4
Details	binding site for residue GOL B 605

Chain	Residue
B	TYR442
B	THR443
B	GLU444
B	HOH736

site_id	AD4
Number of Residues	16
Details	binding site for residue GDP C 601

Chain	Residue
C	ILE432
C	GLY449
C	VAL450
C	ASP453
C	SER469
C	GLN470
C	VAL471
C	GLY219
C	TYR220
C	GLY221
C	CYS222
C	TYR250
C	HIS363
C	ARG365
C	ALA407
C	THR408

site_id	AD5
Number of Residues	2
Details	binding site for residue EDO C 602

Chain	Residue
C	ARG559
C	ILE562

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO D 601

Chain	Residue
D	ILE508
D	ARG559
D	ILE562

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO D 602

Chain	Residue
D	SER468
D	GLN470
D	ARG473
D	TYR498

site_id	AD8
Number of Residues	4
Details	binding site for residue EDO D 603

Chain	Residue
D	ARG365
D	SER469
D	GLN470
D	VAL471

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	574
Details	Domain: {"description":"GT23","evidences":[{"source":"PROSITE-ProRule","id":"PRU00992","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	244
Details	Domain: {"description":"SH3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"Important for donor substrate binding"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Motif: {"description":"SH3-binding","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9WTS2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)