6X5H
Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0001701 | biological_process | in utero embryonic development |
| A | 0005515 | molecular_function | protein binding |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006487 | biological_process | protein N-linked glycosylation |
| A | 0006491 | biological_process | N-glycan processing |
| A | 0008424 | molecular_function | glycoprotein 6-alpha-L-fucosyltransferase activity |
| A | 0009101 | biological_process | glycoprotein biosynthetic process |
| A | 0009312 | biological_process | oligosaccharide biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0019082 | biological_process | viral protein processing |
| A | 0032580 | cellular_component | Golgi cisterna membrane |
| A | 0036066 | biological_process | protein O-linked glycosylation via fucose |
| A | 0042355 | biological_process | L-fucose catabolic process |
| A | 0046368 | biological_process | GDP-L-fucose metabolic process |
| A | 0046921 | molecular_function | alpha-(1->6)-fucosyltransferase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0001701 | biological_process | in utero embryonic development |
| B | 0005515 | molecular_function | protein binding |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006487 | biological_process | protein N-linked glycosylation |
| B | 0006491 | biological_process | N-glycan processing |
| B | 0008424 | molecular_function | glycoprotein 6-alpha-L-fucosyltransferase activity |
| B | 0009101 | biological_process | glycoprotein biosynthetic process |
| B | 0009312 | biological_process | oligosaccharide biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0019082 | biological_process | viral protein processing |
| B | 0032580 | cellular_component | Golgi cisterna membrane |
| B | 0036066 | biological_process | protein O-linked glycosylation via fucose |
| B | 0042355 | biological_process | L-fucose catabolic process |
| B | 0046368 | biological_process | GDP-L-fucose metabolic process |
| B | 0046921 | molecular_function | alpha-(1->6)-fucosyltransferase activity |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0000139 | cellular_component | Golgi membrane |
| C | 0001701 | biological_process | in utero embryonic development |
| C | 0005515 | molecular_function | protein binding |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0006487 | biological_process | protein N-linked glycosylation |
| C | 0006491 | biological_process | N-glycan processing |
| C | 0008424 | molecular_function | glycoprotein 6-alpha-L-fucosyltransferase activity |
| C | 0009101 | biological_process | glycoprotein biosynthetic process |
| C | 0009312 | biological_process | oligosaccharide biosynthetic process |
| C | 0016020 | cellular_component | membrane |
| C | 0019082 | biological_process | viral protein processing |
| C | 0032580 | cellular_component | Golgi cisterna membrane |
| C | 0036066 | biological_process | protein O-linked glycosylation via fucose |
| C | 0042355 | biological_process | L-fucose catabolic process |
| C | 0046368 | biological_process | GDP-L-fucose metabolic process |
| C | 0046921 | molecular_function | alpha-(1->6)-fucosyltransferase activity |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0000139 | cellular_component | Golgi membrane |
| D | 0001701 | biological_process | in utero embryonic development |
| D | 0005515 | molecular_function | protein binding |
| D | 0005794 | cellular_component | Golgi apparatus |
| D | 0006487 | biological_process | protein N-linked glycosylation |
| D | 0006491 | biological_process | N-glycan processing |
| D | 0008424 | molecular_function | glycoprotein 6-alpha-L-fucosyltransferase activity |
| D | 0009101 | biological_process | glycoprotein biosynthetic process |
| D | 0009312 | biological_process | oligosaccharide biosynthetic process |
| D | 0016020 | cellular_component | membrane |
| D | 0019082 | biological_process | viral protein processing |
| D | 0032580 | cellular_component | Golgi cisterna membrane |
| D | 0036066 | biological_process | protein O-linked glycosylation via fucose |
| D | 0042355 | biological_process | L-fucose catabolic process |
| D | 0046368 | biological_process | GDP-L-fucose metabolic process |
| D | 0046921 | molecular_function | alpha-(1->6)-fucosyltransferase activity |
| D | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue GDP A 601 |
| Chain | Residue |
| A | GLY219 |
| A | THR408 |
| A | ILE432 |
| A | ALA436 |
| A | ARG441 |
| A | GLY449 |
| A | VAL450 |
| A | ASP453 |
| A | SER468 |
| A | SER469 |
| A | GLN470 |
| A | TYR220 |
| A | VAL471 |
| A | HOH710 |
| A | HOH738 |
| A | HOH771 |
| A | HOH788 |
| A | HOH916 |
| A | GLY221 |
| A | CYS222 |
| A | TYR250 |
| A | HIS363 |
| A | ARG365 |
| A | LYS369 |
| A | ALA407 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | PRO568 |
| A | THR569 |
| A | TYR570 |
| A | PRO571 |
| A | HOH728 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 603 |
| Chain | Residue |
| A | GLU387 |
| A | LYS402 |
| A | TYR421 |
| A | PRO422 |
| A | ASN423 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 604 |
| Chain | Residue |
| A | ASP429 |
| A | ASN430 |
| A | SER431 |
| A | LYS566 |
| A | HOH851 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 605 |
| Chain | Residue |
| A | HOH957 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | HIS483 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 607 |
| Chain | Residue |
| A | GLY217 |
| A | CYS218 |
| A | ARG249 |
| A | TYR442 |
| site_id | AC8 |
| Number of Residues | 26 |
| Details | binding site for residue GDP B 601 |
| Chain | Residue |
| B | GLY219 |
| B | TYR220 |
| B | GLY221 |
| B | CYS222 |
| B | TYR250 |
| B | HIS363 |
| B | ARG365 |
| B | LYS369 |
| B | ALA407 |
| B | THR408 |
| B | ILE432 |
| B | ALA436 |
| B | ARG441 |
| B | GLY449 |
| B | VAL450 |
| B | ASP453 |
| B | SER468 |
| B | SER469 |
| B | GLN470 |
| B | VAL471 |
| B | HOH704 |
| B | HOH724 |
| B | HOH766 |
| B | HOH849 |
| B | HOH865 |
| B | HOH971 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 602 |
| Chain | Residue |
| B | GLN238 |
| B | PRO568 |
| B | THR569 |
| B | TYR570 |
| B | PRO571 |
| B | HOH728 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 603 |
| Chain | Residue |
| B | GLY217 |
| B | ARG249 |
| B | TYR442 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| B | LYS402 |
| B | LYS420 |
| B | TYR421 |
| B | PRO422 |
| B | ASN423 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | TYR442 |
| B | THR443 |
| B | GLU444 |
| B | HOH736 |
| site_id | AD4 |
| Number of Residues | 16 |
| Details | binding site for residue GDP C 601 |
| Chain | Residue |
| C | ILE432 |
| C | GLY449 |
| C | VAL450 |
| C | ASP453 |
| C | SER469 |
| C | GLN470 |
| C | VAL471 |
| C | GLY219 |
| C | TYR220 |
| C | GLY221 |
| C | CYS222 |
| C | TYR250 |
| C | HIS363 |
| C | ARG365 |
| C | ALA407 |
| C | THR408 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 602 |
| Chain | Residue |
| C | ARG559 |
| C | ILE562 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 601 |
| Chain | Residue |
| D | ILE508 |
| D | ARG559 |
| D | ILE562 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 602 |
| Chain | Residue |
| D | SER468 |
| D | GLN470 |
| D | ARG473 |
| D | TYR498 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 603 |
| Chain | Residue |
| D | ARG365 |
| D | SER469 |
| D | GLN470 |
| D | VAL471 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 574 |
| Details | Domain: {"description":"GT23","evidences":[{"source":"PROSITE-ProRule","id":"PRU00992","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 244 |
| Details | Domain: {"description":"SH3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Region: {"description":"Important for donor substrate binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Motif: {"description":"SH3-binding","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9WTS2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
