6WJC
Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016907 | molecular_function | G protein-coupled acetylcholine receptor activity |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0040012 | biological_process | regulation of locomotion |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
| A | 0046541 | biological_process | saliva secretion |
| A | 0050890 | biological_process | cognition |
| C | 0005576 | cellular_component | extracellular region |
| C | 0035821 | biological_process | modulation of process of another organism |
| C | 0048019 | molecular_function | receptor antagonist activity |
| C | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue ACM A 501 |
| Chain | Residue |
| A | ARG365 |
| A | LEU420 |
| A | CYS421 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 A 502 |
| Chain | Residue |
| A | THR31 |
| A | GLY33 |
| A | THR84 |
| A | ALA92 |
| A | LEU93 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue Y01 A 503 |
| Chain | Residue |
| A | PHE27 |
| A | LEU35 |
| A | THR398 |
| A | LEU399 |
| A | LEU402 |
| A | GLN24 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 A 504 |
| Chain | Residue |
| A | TYR62 |
| A | PRO139 |
| A | ALA143 |
| A | ILE146 |
| A | Y01505 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue Y01 A 505 |
| Chain | Residue |
| A | LEU47 |
| A | PHE50 |
| A | LYS51 |
| A | LYS57 |
| A | CYS69 |
| A | Y01504 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue OIN A 506 |
| Chain | Residue |
| A | ASP105 |
| A | TYR106 |
| A | SER109 |
| A | GLN110 |
| A | ALA193 |
| A | TRP378 |
| A | TYR381 |
| A | ASN382 |
| A | TYR404 |
Functional Information from PROSITE/UniProt
| site_id | PS00272 |
| Number of Residues | 21 |
| Details | SNAKE_TOXIN Snake toxins signature. GCaatCPkaeyrdvin.CCgtD |
| Chain | Residue | Details |
| C | GLY41-ASP61 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC |
| Chain | Residue | Details |
| A | TRP23-ILE48 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 72 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC |
| Chain | Residue | Details |
| A | SER49-TYR62 | |
| A | ASP122-ALA142 | |
| A | CYS421-CYS460 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC |
| Chain | Residue | Details |
| A | PHE63-THR84 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 36 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC |
| Chain | Residue | Details |
| A | TYR85-THR95 | |
| A | GLN165-GLN185 | |
| A | CYS391-GLU397 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC |
| Chain | Residue | Details |
| A | LEU96-PHE121 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC |
| Chain | Residue | Details |
| A | ALA143-TRP164 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC |
| Chain | Residue | Details |
| A | PRO186-TRP209 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC |
| Chain | Residue | Details |
| A | LEU367-PHE390 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:32646996, ECO:0007744|PDB:6WJC |
| Chain | Residue | Details |
| A | THR398-LEU420 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | SITE: Subtype-specific residue that binds to snake venom muscarinic toxin 7 => ECO:0000269|PubMed:32646996 |
| Chain | Residue | Details |
| A | GLU170 | |
| A | LEU174 | |
| A | GLU397 | |
| A | GLU401 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Binds to snake venom muscarinic toxin 7 => ECO:0000269|PubMed:32646996 |
| Chain | Residue | Details |
| A | THR172 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000255 |
| Chain | Residue | Details |
| A | THR428 | |
| A | THR455 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000255 |
| Chain | Residue | Details |
| A | SER451 | |
| A | SER457 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | GLN2 | |
| A | GLN12 |
