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6WC5

Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
A0003677molecular_functionDNA binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046983molecular_functionprotein dimerization activity
B0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
B0003677molecular_functionDNA binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046983molecular_functionprotein dimerization activity
C0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
C0003677molecular_functionDNA binding
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046983molecular_functionprotein dimerization activity
D0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
D0003677molecular_functionDNA binding
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046983molecular_functionprotein dimerization activity
I0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
I0003677molecular_functionDNA binding
I0006355biological_processregulation of DNA-templated transcription
N0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
N0003677molecular_functionDNA binding
N0006355biological_processregulation of DNA-templated transcription
Functional Information from PROSITE/UniProt
site_idPS00027
Number of Residues24
DetailsHOMEOBOX_1 'Homeobox' domain signature. LAsvLkLTstQVKIWFqNrryksK
ChainResidueDetails
ILEU171-LYS194

site_idPS00350
Number of Residues55
DetailsMADS_BOX_1 MADS-box domain signature. RkKiqisrIlDqrnRqvTFtKRKfgLmKKAyELSvLcdceIaLIIfnsanrLfqY
ChainResidueDetails
AARG3-TYR57

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues112
DetailsDNA_BIND: Mef2-type => ECO:0000255
ChainResidueDetails
AALA58-GLU86
BALA58-GLU86
CALA58-GLU86
DALA58-GLU86

224004

PDB entries from 2024-08-21

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