Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WBM

Cryo-EM structure of human Pannexin 1 channel N255A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006812	biological_process	monoatomic cation transport
A	0015267	molecular_function	channel activity
A	0032732	biological_process	positive regulation of interleukin-1 production
B	0006812	biological_process	monoatomic cation transport
B	0015267	molecular_function	channel activity
B	0032732	biological_process	positive regulation of interleukin-1 production
C	0006812	biological_process	monoatomic cation transport
C	0015267	molecular_function	channel activity
C	0032732	biological_process	positive regulation of interleukin-1 production
D	0006812	biological_process	monoatomic cation transport
D	0015267	molecular_function	channel activity
D	0032732	biological_process	positive regulation of interleukin-1 production
E	0006812	biological_process	monoatomic cation transport
E	0015267	molecular_function	channel activity
E	0032732	biological_process	positive regulation of interleukin-1 production
F	0006812	biological_process	monoatomic cation transport
F	0015267	molecular_function	channel activity
F	0032732	biological_process	positive regulation of interleukin-1 production
G	0006812	biological_process	monoatomic cation transport
G	0015267	molecular_function	channel activity
G	0032732	biological_process	positive regulation of interleukin-1 production

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue PTY A 401

Chain	Residue
A	GLY99
A	ASN100
A	LEU101
A	TRP104
A	LEU115
A	CLR405
B	ILE279
B	PTY402

site_id	AC2
Number of Residues	7
Details	binding site for residue PTY A 402

Chain	Residue
A	LEU237
A	SER239
A	GLN274
A	LEU275
A	VAL278
G	PTY401
A	PHE235

site_id	AC3
Number of Residues	8
Details	binding site for residue 3PE A 403

Chain	Residue
A	MET37
A	TYR293
A	ARG300
A	GLU336
G	PHE126
G	PHE129
G	SER215
G	LEU219

site_id	AC4
Number of Residues	4
Details	binding site for residue DGA A 404

Chain	Residue
A	LEU17
A	MET37
A	ILE41
G	PHE129

site_id	AC5
Number of Residues	2
Details	binding site for residue CLR A 405

Chain	Residue
A	TYR230
A	PTY401

site_id	AC6
Number of Residues	2
Details	binding site for residue CLR A 406

Chain	Residue
A	ILE229
A	SER236

site_id	AC7
Number of Residues	4
Details	binding site for residue DGA A 407

Chain	Residue
A	PHE129
B	LEU17
B	MET37
B	ILE41

site_id	AC8
Number of Residues	8
Details	binding site for residue PTY B 401

Chain	Residue
B	GLY99
B	ASN100
B	LEU101
B	TRP104
B	LEU115
B	CLR404
C	ILE279
C	PTY402

site_id	AC9
Number of Residues	7
Details	binding site for residue PTY B 402

Chain	Residue
A	PTY401
B	PHE235
B	LEU237
B	SER239
B	GLN274
B	LEU275
B	VAL278

site_id	AD1
Number of Residues	8
Details	binding site for residue 3PE B 403

Chain	Residue
A	PHE126
A	PHE129
A	SER215
A	LEU219
B	MET37
B	TYR293
B	ARG300
B	GLU336

site_id	AD2
Number of Residues	2
Details	binding site for residue CLR B 404

Chain	Residue
B	TYR230
B	PTY401

site_id	AD3
Number of Residues	2
Details	binding site for residue CLR B 405

Chain	Residue
B	ILE229
B	SER236

site_id	AD4
Number of Residues	5
Details	binding site for residue DGA B 406

Chain	Residue
B	LEU125
B	PHE129
C	LEU17
C	MET37
C	ILE41

site_id	AD5
Number of Residues	8
Details	binding site for residue PTY C 401

Chain	Residue
C	GLY99
C	ASN100
C	LEU101
C	TRP104
C	LEU115
C	CLR404
D	ILE279
D	PTY402

site_id	AD6
Number of Residues	7
Details	binding site for residue PTY C 402

Chain	Residue
B	PTY401
C	PHE235
C	LEU237
C	SER239
C	GLN274
C	LEU275
C	VAL278

site_id	AD7
Number of Residues	8
Details	binding site for residue 3PE C 403

Chain	Residue
B	PHE126
B	PHE129
B	SER215
B	LEU219
C	MET37
C	TYR293
C	ARG300
C	GLU336

site_id	AD8
Number of Residues	2
Details	binding site for residue CLR C 404

Chain	Residue
C	TYR230
C	PTY401

site_id	AD9
Number of Residues	2
Details	binding site for residue CLR C 405

Chain	Residue
C	ILE229
C	SER236

site_id	AE1
Number of Residues	5
Details	binding site for residue DGA C 406

Chain	Residue
C	LEU125
C	PHE129
D	LEU17
D	MET37
D	ILE41

site_id	AE2
Number of Residues	8
Details	binding site for residue PTY D 401

Chain	Residue
D	GLY99
D	ASN100
D	LEU101
D	TRP104
D	LEU115
D	CLR404
E	ILE279
E	PTY402

site_id	AE3
Number of Residues	7
Details	binding site for residue PTY D 402

Chain	Residue
C	PTY401
D	PHE235
D	LEU237
D	SER239
D	GLN274
D	LEU275
D	VAL278

site_id	AE4
Number of Residues	8
Details	binding site for residue 3PE D 403

Chain	Residue
C	PHE126
C	PHE129
C	SER215
C	LEU219
D	MET37
D	TYR293
D	ARG300
D	GLU336

site_id	AE5
Number of Residues	2
Details	binding site for residue CLR D 404

Chain	Residue
D	TYR230
D	PTY401

site_id	AE6
Number of Residues	2
Details	binding site for residue CLR D 405

Chain	Residue
D	ILE229
D	SER236

site_id	AE7
Number of Residues	5
Details	binding site for residue DGA D 406

Chain	Residue
D	LEU125
D	PHE129
E	LEU17
E	MET37
E	ILE41

site_id	AE8
Number of Residues	8
Details	binding site for residue PTY E 401

Chain	Residue
E	GLY99
E	ASN100
E	LEU101
E	TRP104
E	LEU115
E	CLR404
F	ILE279
F	PTY402

site_id	AE9
Number of Residues	7
Details	binding site for residue PTY E 402

Chain	Residue
D	PTY401
E	PHE235
E	LEU237
E	SER239
E	GLN274
E	LEU275
E	VAL278

site_id	AF1
Number of Residues	8
Details	binding site for residue 3PE E 403

Chain	Residue
D	PHE126
D	PHE129
D	SER215
D	LEU219
E	MET37
E	TYR293
E	ARG300
E	GLU336

site_id	AF2
Number of Residues	2
Details	binding site for residue CLR E 404

Chain	Residue
E	TYR230
E	PTY401

site_id	AF3
Number of Residues	2
Details	binding site for residue CLR E 405

Chain	Residue
E	ILE229
E	SER236

site_id	AF4
Number of Residues	5
Details	binding site for residue DGA E 406

Chain	Residue
E	LEU125
E	PHE129
F	LEU17
F	MET37
F	ILE41

site_id	AF5
Number of Residues	8
Details	binding site for residue PTY F 401

Chain	Residue
F	GLY99
F	ASN100
F	LEU101
F	TRP104
F	LEU115
F	CLR404
G	ILE279
G	PTY402

site_id	AF6
Number of Residues	7
Details	binding site for residue PTY F 402

Chain	Residue
E	PTY401
F	PHE235
F	LEU237
F	SER239
F	GLN274
F	LEU275
F	VAL278

site_id	AF7
Number of Residues	8
Details	binding site for residue 3PE F 403

Chain	Residue
E	PHE126
E	PHE129
E	SER215
E	LEU219
F	MET37
F	TYR293
F	ARG300
F	GLU336

site_id	AF8
Number of Residues	2
Details	binding site for residue CLR F 404

Chain	Residue
F	TYR230
F	PTY401

site_id	AF9
Number of Residues	2
Details	binding site for residue CLR F 405

Chain	Residue
F	ILE229
F	SER236

site_id	AG1
Number of Residues	5
Details	binding site for residue DGA F 406

Chain	Residue
F	LEU125
F	PHE129
G	LEU17
G	MET37
G	ILE41

site_id	AG2
Number of Residues	8
Details	binding site for residue PTY G 401

Chain	Residue
A	ILE279
A	PTY402
G	GLY99
G	ASN100
G	LEU101
G	TRP104
G	LEU115
G	CLR404

site_id	AG3
Number of Residues	7
Details	binding site for residue PTY G 402

Chain	Residue
F	PTY401
G	PHE235
G	LEU237
G	SER239
G	GLN274
G	LEU275
G	VAL278

site_id	AG4
Number of Residues	8
Details	binding site for residue 3PE G 403

Chain	Residue
F	PHE126
F	PHE129
F	SER215
F	LEU219
G	MET37
G	TYR293
G	ARG300
G	GLU336

site_id	AG5
Number of Residues	2
Details	binding site for residue CLR G 404

Chain	Residue
G	TYR230
G	PTY401

site_id	AG6
Number of Residues	2
Details	binding site for residue CLR G 405

Chain	Residue
G	ILE229
G	SER236

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	560
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00351","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	497
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	14
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q9JIP4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"30814251","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	7
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17715132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30918116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33947837","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)