6WBM
Cryo-EM structure of human Pannexin 1 channel N255A mutant
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006812 | biological_process | monoatomic cation transport |
A | 0015267 | molecular_function | channel activity |
A | 0032732 | biological_process | positive regulation of interleukin-1 production |
B | 0006812 | biological_process | monoatomic cation transport |
B | 0015267 | molecular_function | channel activity |
B | 0032732 | biological_process | positive regulation of interleukin-1 production |
C | 0006812 | biological_process | monoatomic cation transport |
C | 0015267 | molecular_function | channel activity |
C | 0032732 | biological_process | positive regulation of interleukin-1 production |
D | 0006812 | biological_process | monoatomic cation transport |
D | 0015267 | molecular_function | channel activity |
D | 0032732 | biological_process | positive regulation of interleukin-1 production |
E | 0006812 | biological_process | monoatomic cation transport |
E | 0015267 | molecular_function | channel activity |
E | 0032732 | biological_process | positive regulation of interleukin-1 production |
F | 0006812 | biological_process | monoatomic cation transport |
F | 0015267 | molecular_function | channel activity |
F | 0032732 | biological_process | positive regulation of interleukin-1 production |
G | 0006812 | biological_process | monoatomic cation transport |
G | 0015267 | molecular_function | channel activity |
G | 0032732 | biological_process | positive regulation of interleukin-1 production |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue PTY A 401 |
Chain | Residue |
A | GLY99 |
A | ASN100 |
A | LEU101 |
A | TRP104 |
A | LEU115 |
A | CLR405 |
B | ILE279 |
B | PTY402 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue PTY A 402 |
Chain | Residue |
A | LEU237 |
A | SER239 |
A | GLN274 |
A | LEU275 |
A | VAL278 |
G | PTY401 |
A | PHE235 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue 3PE A 403 |
Chain | Residue |
A | MET37 |
A | TYR293 |
A | ARG300 |
A | GLU336 |
G | PHE126 |
G | PHE129 |
G | SER215 |
G | LEU219 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue DGA A 404 |
Chain | Residue |
A | LEU17 |
A | MET37 |
A | ILE41 |
G | PHE129 |
site_id | AC5 |
Number of Residues | 2 |
Details | binding site for residue CLR A 405 |
Chain | Residue |
A | TYR230 |
A | PTY401 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue CLR A 406 |
Chain | Residue |
A | ILE229 |
A | SER236 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue DGA A 407 |
Chain | Residue |
A | PHE129 |
B | LEU17 |
B | MET37 |
B | ILE41 |
site_id | AC8 |
Number of Residues | 8 |
Details | binding site for residue PTY B 401 |
Chain | Residue |
B | GLY99 |
B | ASN100 |
B | LEU101 |
B | TRP104 |
B | LEU115 |
B | CLR404 |
C | ILE279 |
C | PTY402 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue PTY B 402 |
Chain | Residue |
A | PTY401 |
B | PHE235 |
B | LEU237 |
B | SER239 |
B | GLN274 |
B | LEU275 |
B | VAL278 |
site_id | AD1 |
Number of Residues | 8 |
Details | binding site for residue 3PE B 403 |
Chain | Residue |
A | PHE126 |
A | PHE129 |
A | SER215 |
A | LEU219 |
B | MET37 |
B | TYR293 |
B | ARG300 |
B | GLU336 |
site_id | AD2 |
Number of Residues | 2 |
Details | binding site for residue CLR B 404 |
Chain | Residue |
B | TYR230 |
B | PTY401 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue CLR B 405 |
Chain | Residue |
B | ILE229 |
B | SER236 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue DGA B 406 |
Chain | Residue |
B | LEU125 |
B | PHE129 |
C | LEU17 |
C | MET37 |
C | ILE41 |
site_id | AD5 |
Number of Residues | 8 |
Details | binding site for residue PTY C 401 |
Chain | Residue |
C | GLY99 |
C | ASN100 |
C | LEU101 |
C | TRP104 |
C | LEU115 |
C | CLR404 |
D | ILE279 |
D | PTY402 |
site_id | AD6 |
Number of Residues | 7 |
Details | binding site for residue PTY C 402 |
Chain | Residue |
B | PTY401 |
C | PHE235 |
C | LEU237 |
C | SER239 |
C | GLN274 |
C | LEU275 |
C | VAL278 |
site_id | AD7 |
Number of Residues | 8 |
Details | binding site for residue 3PE C 403 |
Chain | Residue |
B | PHE126 |
B | PHE129 |
B | SER215 |
B | LEU219 |
C | MET37 |
C | TYR293 |
C | ARG300 |
C | GLU336 |
site_id | AD8 |
Number of Residues | 2 |
Details | binding site for residue CLR C 404 |
Chain | Residue |
C | TYR230 |
C | PTY401 |
site_id | AD9 |
Number of Residues | 2 |
Details | binding site for residue CLR C 405 |
Chain | Residue |
C | ILE229 |
C | SER236 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue DGA C 406 |
Chain | Residue |
C | LEU125 |
C | PHE129 |
D | LEU17 |
D | MET37 |
D | ILE41 |
site_id | AE2 |
Number of Residues | 8 |
Details | binding site for residue PTY D 401 |
Chain | Residue |
D | GLY99 |
D | ASN100 |
D | LEU101 |
D | TRP104 |
D | LEU115 |
D | CLR404 |
E | ILE279 |
E | PTY402 |
site_id | AE3 |
Number of Residues | 7 |
Details | binding site for residue PTY D 402 |
Chain | Residue |
C | PTY401 |
D | PHE235 |
D | LEU237 |
D | SER239 |
D | GLN274 |
D | LEU275 |
D | VAL278 |
site_id | AE4 |
Number of Residues | 8 |
Details | binding site for residue 3PE D 403 |
Chain | Residue |
C | PHE126 |
C | PHE129 |
C | SER215 |
C | LEU219 |
D | MET37 |
D | TYR293 |
D | ARG300 |
D | GLU336 |
site_id | AE5 |
Number of Residues | 2 |
Details | binding site for residue CLR D 404 |
Chain | Residue |
D | TYR230 |
D | PTY401 |
site_id | AE6 |
Number of Residues | 2 |
Details | binding site for residue CLR D 405 |
Chain | Residue |
D | ILE229 |
D | SER236 |
site_id | AE7 |
Number of Residues | 5 |
Details | binding site for residue DGA D 406 |
Chain | Residue |
D | LEU125 |
D | PHE129 |
E | LEU17 |
E | MET37 |
E | ILE41 |
site_id | AE8 |
Number of Residues | 8 |
Details | binding site for residue PTY E 401 |
Chain | Residue |
E | GLY99 |
E | ASN100 |
E | LEU101 |
E | TRP104 |
E | LEU115 |
E | CLR404 |
F | ILE279 |
F | PTY402 |
site_id | AE9 |
Number of Residues | 7 |
Details | binding site for residue PTY E 402 |
Chain | Residue |
D | PTY401 |
E | PHE235 |
E | LEU237 |
E | SER239 |
E | GLN274 |
E | LEU275 |
E | VAL278 |
site_id | AF1 |
Number of Residues | 8 |
Details | binding site for residue 3PE E 403 |
Chain | Residue |
D | PHE126 |
D | PHE129 |
D | SER215 |
D | LEU219 |
E | MET37 |
E | TYR293 |
E | ARG300 |
E | GLU336 |
site_id | AF2 |
Number of Residues | 2 |
Details | binding site for residue CLR E 404 |
Chain | Residue |
E | TYR230 |
E | PTY401 |
site_id | AF3 |
Number of Residues | 2 |
Details | binding site for residue CLR E 405 |
Chain | Residue |
E | ILE229 |
E | SER236 |
site_id | AF4 |
Number of Residues | 5 |
Details | binding site for residue DGA E 406 |
Chain | Residue |
E | LEU125 |
E | PHE129 |
F | LEU17 |
F | MET37 |
F | ILE41 |
site_id | AF5 |
Number of Residues | 8 |
Details | binding site for residue PTY F 401 |
Chain | Residue |
F | GLY99 |
F | ASN100 |
F | LEU101 |
F | TRP104 |
F | LEU115 |
F | CLR404 |
G | ILE279 |
G | PTY402 |
site_id | AF6 |
Number of Residues | 7 |
Details | binding site for residue PTY F 402 |
Chain | Residue |
E | PTY401 |
F | PHE235 |
F | LEU237 |
F | SER239 |
F | GLN274 |
F | LEU275 |
F | VAL278 |
site_id | AF7 |
Number of Residues | 8 |
Details | binding site for residue 3PE F 403 |
Chain | Residue |
E | PHE126 |
E | PHE129 |
E | SER215 |
E | LEU219 |
F | MET37 |
F | TYR293 |
F | ARG300 |
F | GLU336 |
site_id | AF8 |
Number of Residues | 2 |
Details | binding site for residue CLR F 404 |
Chain | Residue |
F | TYR230 |
F | PTY401 |
site_id | AF9 |
Number of Residues | 2 |
Details | binding site for residue CLR F 405 |
Chain | Residue |
F | ILE229 |
F | SER236 |
site_id | AG1 |
Number of Residues | 5 |
Details | binding site for residue DGA F 406 |
Chain | Residue |
F | LEU125 |
F | PHE129 |
G | LEU17 |
G | MET37 |
G | ILE41 |
site_id | AG2 |
Number of Residues | 8 |
Details | binding site for residue PTY G 401 |
Chain | Residue |
A | ILE279 |
A | PTY402 |
G | GLY99 |
G | ASN100 |
G | LEU101 |
G | TRP104 |
G | LEU115 |
G | CLR404 |
site_id | AG3 |
Number of Residues | 7 |
Details | binding site for residue PTY G 402 |
Chain | Residue |
F | PTY401 |
G | PHE235 |
G | LEU237 |
G | SER239 |
G | GLN274 |
G | LEU275 |
G | VAL278 |
site_id | AG4 |
Number of Residues | 8 |
Details | binding site for residue 3PE G 403 |
Chain | Residue |
F | PHE126 |
F | PHE129 |
F | SER215 |
F | LEU219 |
G | MET37 |
G | TYR293 |
G | ARG300 |
G | GLU336 |
site_id | AG5 |
Number of Residues | 2 |
Details | binding site for residue CLR G 404 |
Chain | Residue |
G | TYR230 |
G | PTY401 |
site_id | AG6 |
Number of Residues | 2 |
Details | binding site for residue CLR G 405 |
Chain | Residue |
G | ILE229 |
G | SER236 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 896 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | MET1-CYS40 | |
E | ARG128-ARG217 | |
F | MET1-CYS40 | |
F | ARG128-ARG217 | |
G | MET1-CYS40 | |
G | ARG128-ARG217 | |
A | ARG128-ARG217 | |
B | MET1-CYS40 | |
B | ARG128-ARG217 | |
C | MET1-CYS40 | |
C | ARG128-ARG217 | |
D | MET1-CYS40 | |
D | ARG128-ARG217 | |
E | MET1-CYS40 |
site_id | SWS_FT_FI2 |
Number of Residues | 560 |
Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00351 |
Chain | Residue | Details |
A | ILE41-GLY61 | |
C | LYS107-TRP127 | |
C | LEU218-SER238 | |
C | LEU267-LEU287 | |
D | ILE41-GLY61 | |
D | LYS107-TRP127 | |
D | LEU218-SER238 | |
D | LEU267-LEU287 | |
E | ILE41-GLY61 | |
E | LYS107-TRP127 | |
E | LEU218-SER238 | |
A | LYS107-TRP127 | |
E | LEU267-LEU287 | |
F | ILE41-GLY61 | |
F | LYS107-TRP127 | |
F | LEU218-SER238 | |
F | LEU267-LEU287 | |
G | ILE41-GLY61 | |
G | LYS107-TRP127 | |
G | LEU218-SER238 | |
G | LEU267-LEU287 | |
A | LEU218-SER238 | |
A | LEU267-LEU287 | |
B | ILE41-GLY61 | |
B | LYS107-TRP127 | |
B | LEU218-SER238 | |
B | LEU267-LEU287 | |
C | ILE41-GLY61 |
site_id | SWS_FT_FI3 |
Number of Residues | 497 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
A | THR62-HIS106 | |
E | SER239-LYS266 | |
F | THR62-HIS106 | |
F | SER239-LYS266 | |
G | THR62-HIS106 | |
G | SER239-LYS266 | |
A | SER239-LYS266 | |
B | THR62-HIS106 | |
B | SER239-LYS266 | |
C | THR62-HIS106 | |
C | SER239-LYS266 | |
D | THR62-HIS106 | |
D | SER239-LYS266 | |
E | THR62-HIS106 |
site_id | SWS_FT_FI4 |
Number of Residues | 14 |
Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q9JIP4 |
Chain | Residue | Details |
A | CYS40 | |
E | CYS347 | |
F | CYS40 | |
F | CYS347 | |
G | CYS40 | |
G | CYS347 | |
A | CYS347 | |
B | CYS40 | |
B | CYS347 | |
C | CYS40 | |
C | CYS347 | |
D | CYS40 | |
D | CYS347 | |
E | CYS40 |
site_id | SWS_FT_FI5 |
Number of Residues | 7 |
Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:30814251 |
Chain | Residue | Details |
A | TYR199 | |
B | TYR199 | |
C | TYR199 | |
D | TYR199 | |
E | TYR199 | |
F | TYR199 | |
G | TYR199 |
site_id | SWS_FT_FI6 |
Number of Residues | 7 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17715132, ECO:0000269|PubMed:30918116, ECO:0000269|PubMed:32494015, ECO:0000269|PubMed:33947837 |
Chain | Residue | Details |
A | ALA255 | |
B | ALA255 | |
C | ALA255 | |
D | ALA255 | |
E | ALA255 | |
F | ALA255 | |
G | ALA255 |