6WBG
Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0015267 | molecular_function | channel activity |
| A | 0032732 | biological_process | positive regulation of interleukin-1 production |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0015267 | molecular_function | channel activity |
| B | 0032732 | biological_process | positive regulation of interleukin-1 production |
| C | 0006812 | biological_process | monoatomic cation transport |
| C | 0015267 | molecular_function | channel activity |
| C | 0032732 | biological_process | positive regulation of interleukin-1 production |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0015267 | molecular_function | channel activity |
| D | 0032732 | biological_process | positive regulation of interleukin-1 production |
| E | 0006812 | biological_process | monoatomic cation transport |
| E | 0015267 | molecular_function | channel activity |
| E | 0032732 | biological_process | positive regulation of interleukin-1 production |
| F | 0006812 | biological_process | monoatomic cation transport |
| F | 0015267 | molecular_function | channel activity |
| F | 0032732 | biological_process | positive regulation of interleukin-1 production |
| G | 0006812 | biological_process | monoatomic cation transport |
| G | 0015267 | molecular_function | channel activity |
| G | 0032732 | biological_process | positive regulation of interleukin-1 production |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 560 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00351","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 497 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q9JIP4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"30814251","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17715132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30918116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33947837","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
