6W7S
Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 2G10
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue MES A 2001 |
| Chain | Residue |
| A | ALA1754 |
| A | THR1755 |
| A | LYS1776 |
| A | TYR1813 |
| A | ASN1817 |
| A | PHE1856 |
| A | HOH2163 |
| A | HOH2219 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue CL L 301 |
| Chain | Residue |
| L | THR123 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 177 |
| Details | Region: {"description":"Beta-ketoacyl reductase 1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For beta-ketoacyl reductase 1 activity","evidences":[{"source":"UniProtKB","id":"Q03132","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"16564177","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16564177","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Could be the principal determinant of stereospecificity","evidences":[{"source":"PubMed","id":"16564177","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
