6W7S

Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 2G10

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue MES A 2001

Chain	Residue
A	ALA1754
A	THR1755
A	LYS1776
A	TYR1813
A	ASN1817
A	PHE1856
A	HOH2163
A	HOH2219

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site_id	AC2
Number of Residues	1
Details	binding site for residue CL L 301

Chain	Residue
L	THR123

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Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. EPA..RLDGTWLVA

Chain	Residue	Details
A	GLU1466-ALA1477

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
L	TYR215-HIS221
H	TYR207-HIS213

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For beta-ketoacyl reductase 1 activity => ECO:0000250|UniProtKB:Q03132, ECO:0000305|PubMed:16564177

Chain	Residue	Details
A	TYR1813

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:16564177

Chain	Residue	Details
A	THR1674
A	SER1697
A	ASP1726
A	LYS1776
A	PHE1798

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Could be the principal determinant of stereospecificity => ECO:0000305|PubMed:16564177

Chain	Residue	Details
A	PHE1801

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