6W13
Human 8-oxoguanine glycosylase interrogating fully intrahelical oxoG lesion DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003684 | molecular_function | damaged DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006281 | biological_process | DNA repair |
| A | 0006284 | biological_process | base-excision repair |
| A | 0006285 | biological_process | base-excision repair, AP site formation |
| A | 0006289 | biological_process | nucleotide-excision repair |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006974 | biological_process | DNA damage response |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0008534 | molecular_function | oxidized purine nucleobase lesion DNA N-glycosylase activity |
| A | 0009314 | biological_process | response to radiation |
| A | 0016363 | cellular_component | nuclear matrix |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0032357 | molecular_function | oxidized purine DNA binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034039 | molecular_function | 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
| A | 0034614 | biological_process | cellular response to reactive oxygen species |
| A | 0044029 | biological_process | positive regulation of gene expression via chromosomal CpG island demethylation |
| A | 0045007 | biological_process | depurination |
| A | 0045008 | biological_process | depyrimidination |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0140078 | molecular_function | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
| A | 1901291 | biological_process | negative regulation of double-strand break repair via single-strand annealing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | GLN43 |
| A | GLN135 |
| A | SER143 |
| A | HOH555 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | CYS241 |
| A | LEU243 |
| A | VAL246 |
| A | HOH536 |
| B | DC26 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | HIS112 |
| A | TRP113 |
| A | ASP175 |
| A | TRP307 |
| A | GLY308 |
| A | PRO309 |
| A | TYR310 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 404 |
| Chain | Residue |
| A | LEU187 |
| A | ALA188 |
| A | GLY189 |
| A | VAL192 |
| A | SER209 |
| A | ARG213 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 405 |
| Chain | Residue |
| A | TYR233 |
| A | ASP252 |
| A | HOH534 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 406 |
| Chain | Residue |
| A | VAL58 |
| A | ASP136 |
| A | GLU139 |
| A | HOH501 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue S5Y B 101 |
| Chain | Residue |
| A | TYR203 |
| A | CYS207 |
| B | DG24 |
| B | DT25 |
| C | DC7 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"9197244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10706276","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11902834","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12578369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12592398","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15610848","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 185 |
| Chain | Residue | Details |
| A | LYS249 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | ASP268 | electrostatic stabiliser, hydrogen bond acceptor |
