6W0O
Amyloid-beta(1-40) fibril derived from Alzheimer's disease cortical tissue
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 1 | 0007399 | biological_process | nervous system development |
| 1 | 0016021 | cellular_component | integral component of membrane |
| 2 | 0007399 | biological_process | nervous system development |
| 2 | 0016021 | cellular_component | integral component of membrane |
| 3 | 0007399 | biological_process | nervous system development |
| 3 | 0016021 | cellular_component | integral component of membrane |
| 4 | 0007399 | biological_process | nervous system development |
| 4 | 0016021 | cellular_component | integral component of membrane |
| 5 | 0007399 | biological_process | nervous system development |
| 5 | 0016021 | cellular_component | integral component of membrane |
| 6 | 0007399 | biological_process | nervous system development |
| 6 | 0016021 | cellular_component | integral component of membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Peptide: {"description":"P3(40)","featureId":"PRO_0000000096"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10413512","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10413512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Site: {"description":"Cleavage; by alpha-secretase","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Site: {"description":"Cleavage; by theta-secretase","evidences":[{"source":"PubMed","id":"16816112","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Site: {"description":"Implicated in free radical propagation","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Site: {"description":"Susceptible to oxidation","evidences":[{"source":"PubMed","id":"10535332","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"O-linked (HexNAc...) tyrosine; partial","evidences":[{"source":"PubMed","id":"22576872","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
