6W0O
Amyloid-beta(1-40) fibril derived from Alzheimer's disease cortical tissue
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 1 | 0007399 | biological_process | nervous system development |
| 1 | 0016021 | cellular_component | integral component of membrane |
| 2 | 0007399 | biological_process | nervous system development |
| 2 | 0016021 | cellular_component | integral component of membrane |
| 3 | 0007399 | biological_process | nervous system development |
| 3 | 0016021 | cellular_component | integral component of membrane |
| 4 | 0007399 | biological_process | nervous system development |
| 4 | 0016021 | cellular_component | integral component of membrane |
| 5 | 0007399 | biological_process | nervous system development |
| 5 | 0016021 | cellular_component | integral component of membrane |
| 6 | 0007399 | biological_process | nervous system development |
| 6 | 0016021 | cellular_component | integral component of membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| 1 | GLY25 | |
| 5 | GLY33 | |
| 6 | GLY25 | |
| 6 | GLY33 | |
| 1 | GLY33 | |
| 2 | GLY25 | |
| 2 | GLY33 | |
| 3 | GLY25 | |
| 3 | GLY33 | |
| 4 | GLY25 | |
| 4 | GLY33 | |
| 5 | GLY25 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
| Chain | Residue | Details |
| 1 | GLY29 | |
| 2 | GLY29 | |
| 3 | GLY29 | |
| 4 | GLY29 | |
| 5 | GLY29 | |
| 6 | GLY29 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| 1 | ILE32 | |
| 2 | ILE32 | |
| 3 | ILE32 | |
| 4 | ILE32 | |
| 5 | ILE32 | |
| 6 | ILE32 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by beta-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| 1 | PHE19 | |
| 2 | PHE19 | |
| 3 | PHE19 | |
| 4 | PHE19 | |
| 5 | PHE19 | |
| 6 | PHE19 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
| Chain | Residue | Details |
| 1 | PHE20 | |
| 2 | PHE20 | |
| 3 | PHE20 | |
| 4 | PHE20 | |
| 5 | PHE20 | |
| 6 | PHE20 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
| Chain | Residue | Details |
| 1 | SER26 | |
| 2 | SER26 | |
| 3 | SER26 | |
| 4 | SER26 | |
| 5 | SER26 | |
| 6 | SER26 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| 1 | MET35 | |
| 2 | MET35 | |
| 3 | MET35 | |
| 4 | MET35 | |
| 5 | MET35 | |
| 6 | MET35 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
| Chain | Residue | Details |
| 1 | GLY38 | |
| 2 | GLY38 | |
| 3 | GLY38 | |
| 4 | GLY38 | |
| 5 | GLY38 | |
| 6 | GLY38 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine; in L-APP isoforms => ECO:0000269|PubMed:21712440 |
| Chain | Residue | Details |
| 1 | PHE4 | |
| 2 | PHE4 | |
| 3 | PHE4 | |
| 4 | PHE4 | |
| 5 | PHE4 | |
| 6 | PHE4 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (HexNAc...) threonine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| 1 | ASP7 | |
| 2 | ASP7 | |
| 3 | ASP7 | |
| 4 | ASP7 | |
| 5 | ASP7 | |
| 6 | ASP7 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GalNAc...) threonine; partial => ECO:0000269|PubMed:22576872, ECO:0000305|PubMed:21712440 |
| Chain | Residue | Details |
| 1 | GLU11 | |
| 2 | GLU11 | |
| 3 | GLU11 | |
| 4 | GLU11 | |
| 5 | GLU11 | |
| 6 | GLU11 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GalNAc...) serine; partial => ECO:0000269|PubMed:22576872, ECO:0000305|PubMed:21712440 |
| Chain | Residue | Details |
| 1 | GLN15 | |
| 2 | GLN15 | |
| 3 | GLN15 | |
| 4 | GLN15 | |
| 5 | GLN15 | |
| 6 | GLN15 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| 1 | GLY29 | |
| 2 | GLY29 | |
| 3 | GLY29 | |
| 4 | GLY29 | |
| 5 | GLY29 | |
| 6 | GLY29 |
