6VMJ

Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12

Functional Information from GO Data

Chain	GOid	namespace	contents
W	0004252	molecular_function	serine-type endopeptidase activity
W	0005576	cellular_component	extracellular region
W	0006508	biological_process	proteolysis
W	0006956	biological_process	complement activation
W	0006957	biological_process	complement activation, alternative pathway
W	0008236	molecular_function	serine-type peptidase activity
W	0031093	cellular_component	platelet alpha granule lumen
W	0031638	biological_process	zymogen activation
W	0034774	cellular_component	secretory granule lumen
W	0051604	biological_process	protein maturation
W	0070062	cellular_component	extracellular exosome
W	1904813	cellular_component	ficolin-1-rich granule lumen
X	0004252	molecular_function	serine-type endopeptidase activity
X	0005576	cellular_component	extracellular region
X	0006508	biological_process	proteolysis
X	0006956	biological_process	complement activation
X	0006957	biological_process	complement activation, alternative pathway
X	0008236	molecular_function	serine-type peptidase activity
X	0031093	cellular_component	platelet alpha granule lumen
X	0031638	biological_process	zymogen activation
X	0034774	cellular_component	secretory granule lumen
X	0051604	biological_process	protein maturation
X	0070062	cellular_component	extracellular exosome
X	1904813	cellular_component	ficolin-1-rich granule lumen
Y	0004252	molecular_function	serine-type endopeptidase activity
Y	0005576	cellular_component	extracellular region
Y	0006508	biological_process	proteolysis
Y	0006956	biological_process	complement activation
Y	0006957	biological_process	complement activation, alternative pathway
Y	0008236	molecular_function	serine-type peptidase activity
Y	0031093	cellular_component	platelet alpha granule lumen
Y	0031638	biological_process	zymogen activation
Y	0034774	cellular_component	secretory granule lumen
Y	0051604	biological_process	protein maturation
Y	0070062	cellular_component	extracellular exosome
Y	1904813	cellular_component	ficolin-1-rich granule lumen
Z	0004252	molecular_function	serine-type endopeptidase activity
Z	0005576	cellular_component	extracellular region
Z	0006508	biological_process	proteolysis
Z	0006956	biological_process	complement activation
Z	0006957	biological_process	complement activation, alternative pathway
Z	0008236	molecular_function	serine-type peptidase activity
Z	0031093	cellular_component	platelet alpha granule lumen
Z	0031638	biological_process	zymogen activation
Z	0034774	cellular_component	secretory granule lumen
Z	0051604	biological_process	protein maturation
Z	0070062	cellular_component	extracellular exosome
Z	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CIT B 301

Chain	Residue
B	TYR32
B	ARG94
B	GLY97
B	PHE98
B	TYR100

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CIT F 301

Chain	Residue
F	ARG94
F	GLY97
F	PHE98
F	TYR100

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CIT J 301

Chain	Residue
J	ARG94
J	GLY97
J	PHE98
J	TYR100

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CIT M 301

Chain	Residue
M	ARG94
M	GLY97
M	PHE98
M	TYR100

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CIT W 301

Chain	Residue
W	ARG20
W	GLU21
W	GLU23
W	ARG27
W	HIS157

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CIT X 301

Chain	Residue
X	ARG20
X	ALA22
X	GLU23
X	ARG27
X	HIS157

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC

Chain	Residue	Details
W	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV

Chain	Residue	Details
W	ASP189-VAL200

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
A	TYR192-HIS198
B	TYR194-HIS200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	908
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Region: {"description":"Self-inhibitor loop","evidences":[{"source":"PubMed","id":"10022823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9753554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9753554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21205667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22362762","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---