6VG6

Crystal structure of DPO4 with 8-oxoadenine (oxoA) and dGTP*

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0042276	biological_process	error-prone translesion synthesis
A	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0005737	cellular_component	cytoplasm
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0042276	biological_process	error-prone translesion synthesis
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue XG4 P 101

Chain	Residue
A	ASP7
A	MET76
A	ASP105
A	LYS159
A	MG402
P	DC13
P	MG102
T	A385
T	DG6
A	PHE8
A	TYR10
A	PHE11
A	TYR12
A	ALA44
A	THR45
A	TYR48
A	ARG51

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG P 102

Chain	Residue
A	ASP7
A	ASP105
A	GLU106
P	DC13
P	XG4101

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 401

Chain	Residue
A	ASP156
A	ALA181
A	ASP182
A	VAL183
A	ILE186
P	DT12

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG A 402

Chain	Residue
A	ASP7
A	PHE8
A	ASP105
P	XG4101

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL D 401

Chain	Residue
D	ASP156
D	ALA181
D	VAL183
D	ILE186

---

site_id	AC6
Number of Residues	15
Details	binding site for residue XG4 D 402

Chain	Residue
B	DC13
C	A385
C	DG6
D	ASP7
D	PHE8
D	TYR10
D	TYR12
D	THR45
D	TYR48
D	ARG51
D	MET76
D	ASP105
D	LYS159
D	MG403
D	MG404

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MG D 403

Chain	Residue
B	DC13
D	ASP7
D	ASP105
D	GLU106
D	XG4402
D	MG404

---

site_id	AC8
Number of Residues	5
Details	binding site for residue MG D 404

Chain	Residue
D	ASP7
D	PHE8
D	ASP105
D	XG4402
D	MG403

---

site_id	AC9
Number of Residues	11
Details	binding site for Di-nucleotide DT C 4 and A38 C 5

Chain	Residue
C	DA3
C	DG6
D	SER34
D	PHE37
D	SER40
D	GLY41
D	ALA42
D	PRO60
D	ARG331
D	ARG332
D	XG4402

---

site_id	AD1
Number of Residues	14
Details	binding site for Di-nucleotide A38 C 5 and DG C 6

Chain	Residue
B	DT12
B	DC13
C	DT4
C	DA7
D	SER34
D	GLY41
D	ALA42
D	ARG247
D	ILE248
D	VAL249
D	THR250
D	ARG331
D	ARG332
D	XG4402

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
A	GLU106
D	GLU106

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	ASP7
A	ASP105
D	ASP7
D	ASP105

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Substrate discrimination

Chain	Residue	Details
A	TYR12
D	TYR12

---