6VAF
Structure of mono-ubiquitinated FANCD2 bound to non-ubiquitinated FANCI and to DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000785 | cellular_component | chromatin |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0007049 | biological_process | cell cycle |
| A | 0016020 | cellular_component | membrane |
| A | 0031398 | biological_process | positive regulation of protein ubiquitination |
| A | 0036297 | biological_process | interstrand cross-link repair |
| A | 0070182 | molecular_function | DNA polymerase binding |
| A | 1990391 | cellular_component | DNA repair complex |
| B | 0000785 | cellular_component | chromatin |
| B | 0000793 | cellular_component | condensed chromosome |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006281 | biological_process | DNA repair |
| B | 0006974 | biological_process | DNA damage response |
| B | 0007049 | biological_process | cell cycle |
| B | 0007129 | biological_process | homologous chromosome pairing at meiosis |
| B | 0007276 | biological_process | gamete generation |
| B | 0010332 | biological_process | response to gamma radiation |
| B | 0016604 | cellular_component | nuclear body |
| B | 0031573 | biological_process | mitotic intra-S DNA damage checkpoint signaling |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0036297 | biological_process | interstrand cross-link repair |
| B | 0045589 | biological_process | regulation of regulatory T cell differentiation |
| B | 0048854 | biological_process | brain morphogenesis |
| B | 0050727 | biological_process | regulation of inflammatory response |
| B | 0070182 | molecular_function | DNA polymerase binding |
| B | 0097150 | biological_process | neuronal stem cell population maintenance |
| B | 1990391 | cellular_component | DNA repair complex |
| B | 1990918 | biological_process | double-strand break repair involved in meiotic recombination |
| B | 2000348 | biological_process | regulation of CD40 signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| D | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER407 | |
| D | ARG72 | |
| B | SER717 | |
| B | SER1423 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8K368 |
| Chain | Residue | Details |
| A | SER556 | |
| B | SER1404 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:17412408 |
| Chain | Residue | Details |
| A | SER730 | |
| A | SER1121 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:17412408 |
| Chain | Residue | Details |
| A | THR952 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19589784 |
| Chain | Residue | Details |
| A | LYS523 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| D | LYS6 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| B | THR1426 | |
| D | GLY76 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
| Chain | Residue | Details |
| D | LYS11 | |
| D | LYS48 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
| Chain | Residue | Details |
| D | LYS27 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
| Chain | Residue | Details |
| D | LYS29 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
| Chain | Residue | Details |
| D | LYS33 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
| Chain | Residue | Details |
| D | LYS63 |
