6V7I
Structure of KPC-2 bound to Vaborbactam at 1.25 A
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 4D6 A 301 |
| Chain | Residue |
| A | CYS69 |
| A | GLY236 |
| A | THR237 |
| A | HOH408 |
| A | HOH502 |
| A | HOH527 |
| A | SER70 |
| A | TRP105 |
| A | SER130 |
| A | ASN132 |
| A | LEU167 |
| A | ASN170 |
| A | ARG220 |
| A | THR235 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | SER275 |
| A | GLU276 |
| A | ALA277 |
| A | HOH430 |
| A | HOH471 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | ARG61 |
| A | THR254 |
| A | GLY255 |
| A | HOH422 |
| A | HOH466 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | LYS273 |
| A | HIS274 |
| A | HOH507 |
| A | HOH554 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | THR26 |
| A | ARG184 |
| A | PRO226 |
| A | ALA227 |
| A | GLN295 |
| A | HOH401 |
| A | HOH411 |
| A | HOH414 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | GLN205 |
| A | VAL208 |
| A | LYS212 |
| A | TRP251 |
| A | HOH420 |
| A | HOH449 |
| A | HOH524 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile; acyl-ester intermediate => ECO:0000269|PubMed:33257320, ECO:0007744|PDB:6Z23, ECO:0007744|PDB:6Z24 |
| Chain | Residue | Details |
| A | SER70 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU168 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0000269|PubMed:33257320, ECO:0007744|PDB:5UJ3, ECO:0007744|PDB:6Z23, ECO:0007744|PDB:6Z24 |
| Chain | Residue | Details |
| A | SER70 | |
| A | THR237 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0007744|PDB:5UJ3 |
| Chain | Residue | Details |
| A | LYS73 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33257320, ECO:0000312|PDB:6Z24 |
| Chain | Residue | Details |
| A | TRP105 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0000269|PubMed:33257320, ECO:0007744|PDB:5UJ3, ECO:0007744|PDB:6Z23 |
| Chain | Residue | Details |
| A | SER130 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33257320, ECO:0007744|PDB:6Z23, ECO:0007744|PDB:6Z24 |
| Chain | Residue | Details |
| A | ASN132 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0007744|PDB:5UJ3, ECO:0007744|PDB:6Z24 |
| Chain | Residue | Details |
| A | THR235 |
