Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6V4P

Structure of the integrin AlphaIIbBeta3-Abciximab complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007155	biological_process	cell adhesion
A	0008305	cellular_component	integrin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA A 1001

Chain	Residue
A	GLU243
A	ASP245
A	ASP247
A	THR250
A	GLU252

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 1002

Chain	Residue
A	ASP305
A	ASP297
A	ASN299
A	ASP301
A	ARG303

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 1003

Chain	Residue
A	ASP365
A	ASP367
A	ASP369
A	TYR371
A	ASP373

site_id	AC4
Number of Residues	5
Details	binding site for residue CA A 1004

Chain	Residue
A	ASP426
A	ASP428
A	ASN430
A	TYR432
A	ASP434

site_id	AC5
Number of Residues	3
Details	binding site for residue MG B 701

Chain	Residue
B	SER121
B	SER123
B	GLU220

site_id	AC6
Number of Residues	4
Details	binding site for residue CA B 702

Chain	Residue
B	SER123
B	ASP126
B	ASP127
B	MET335

site_id	AC7
Number of Residues	4
Details	binding site for residue CA B 703

Chain	Residue
B	ASP158
B	ASN215
B	ASP217
B	PRO219

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CrCgpGwlGSqC

Chain	Residue	Details
B	CYS460-CYS471
B	CYS547-CYS558

site_id	PS00243
Number of Residues	14
Details	I_EGF_1 Integrins beta chain EGF (I-EGF) domain signature. CsQr..GeClCgqCvC

Chain	Residue	Details
B	CYS495-CYS508
B	CYS536-CYS549
B	CYS575-CYS588

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
C	TYR199-HIS205
D	TYR192-HIS198

site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. CrCgpGWlgsqce..C

Chain	Residue	Details
B	CYS460-CYS473

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	61
Details	Repeat: {"description":"FG-GAP 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	63
Details	Repeat: {"description":"FG-GAP 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	51
Details	Repeat: {"description":"FG-GAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	54
Details	Repeat: {"description":"FG-GAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	65
Details	Repeat: {"description":"FG-GAP 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	59
Details	Repeat: {"description":"FG-GAP 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2775232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2775232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	242
Details	Domain: {"description":"VWFA","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	7
Details	Region: {"description":"Involved in CX3CL1-, NRG1-, FGF1- and IGF1-binding","evidences":[{"source":"PubMed","id":"18441324","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19578119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20682778","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23125415","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Region: {"description":"CX3CL1-binding","evidences":[{"source":"PubMed","id":"24789099","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Binding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"description":"in LIMBS binding site","evidences":[{"source":"PDB","id":"4G1M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"description":"in ADMIDAS binding site and unliganded-closed conformation","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)