6V4P
Structure of the integrin AlphaIIbBeta3-Abciximab complex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1001 |
| Chain | Residue |
| A | GLU243 |
| A | ASP245 |
| A | ASP247 |
| A | THR250 |
| A | GLU252 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1002 |
| Chain | Residue |
| A | ASP305 |
| A | ASP297 |
| A | ASN299 |
| A | ASP301 |
| A | ARG303 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1003 |
| Chain | Residue |
| A | ASP365 |
| A | ASP367 |
| A | ASP369 |
| A | TYR371 |
| A | ASP373 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 1004 |
| Chain | Residue |
| A | ASP426 |
| A | ASP428 |
| A | ASN430 |
| A | TYR432 |
| A | ASP434 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 701 |
| Chain | Residue |
| B | SER121 |
| B | SER123 |
| B | GLU220 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 702 |
| Chain | Residue |
| B | SER123 |
| B | ASP126 |
| B | ASP127 |
| B | MET335 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 703 |
| Chain | Residue |
| B | ASP158 |
| B | ASN215 |
| B | ASP217 |
| B | PRO219 |
Functional Information from PROSITE/UniProt
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CrCgpGwlGSqC |
| Chain | Residue | Details |
| B | CYS460-CYS471 | |
| B | CYS547-CYS558 |
| site_id | PS00243 |
| Number of Residues | 14 |
| Details | I_EGF_1 Integrins beta chain EGF (I-EGF) domain signature. CsQr..GeClCgqCvC |
| Chain | Residue | Details |
| B | CYS495-CYS508 | |
| B | CYS536-CYS549 | |
| B | CYS575-CYS588 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| D | TYR192-HIS198 | |
| C | TYR199-HIS205 |
| site_id | PS01186 |
| Number of Residues | 14 |
| Details | EGF_2 EGF-like domain signature 2. CrCgpGWlgsqce..C |
| Chain | Residue | Details |
| B | CYS460-CYS473 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | SER121 | |
| A | ASP305 | |
| A | ASP365 | |
| A | ASP367 | |
| A | ASP369 | |
| A | TYR371 | |
| A | ASP373 | |
| A | ASP426 | |
| A | ASP428 | |
| A | ASN430 | |
| A | TYR432 | |
| B | GLU220 | |
| A | ASP434 | |
| A | ASP247 | |
| A | THR250 | |
| A | GLU252 | |
| A | ASP297 | |
| A | ASN299 | |
| A | ASP301 | |
| A | ARG303 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | SER123 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASP126 | |
| B | ASP127 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | ASP158 | |
| B | ASN215 | |
| B | ASP217 | |
| B | PRO219 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: in LIMBS binding site => ECO:0007744|PDB:4G1M |
| Chain | Residue | Details |
| B | ASP251 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | MET335 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN99 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN320 | |
| B | ASN371 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN452 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN559 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:1JV2 |
| Chain | Residue | Details |
| B | ASN654 |
