6V3N
Crystal structure of CDYL2 in complex with H3K27me3
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide ARG C 26 and M3L C 27 |
| Chain | Residue |
| A | SER3 |
| C | SER28 |
| C | ALA29 |
| A | GLY4 |
| A | ASP5 |
| A | GLU8 |
| A | TRP29 |
| A | TYR32 |
| A | GLU40 |
| A | HIS44 |
| C | ALA25 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide M3L C 27 and SER C 28 |
| Chain | Residue |
| A | GLY4 |
| A | ASP5 |
| A | TRP29 |
| A | TYR32 |
| A | GLU40 |
| A | HIS44 |
| C | ARG26 |
| C | ALA29 |
| C | PRO30 |
| C | ALA31 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide TYR C 33 and NH2 C 34 |
| Chain | Residue |
| A | THR35 |
| A | ASP37 |
| A | TRP39 |
| C | THR32 |
| D | ALA31 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ARG D 26 and M3L D 27 |
| Chain | Residue |
| B | SER3 |
| B | GLY4 |
| B | ASP5 |
| B | TYR7 |
| B | GLU8 |
| B | TRP29 |
| B | TYR32 |
| B | GLU40 |
| B | HIS44 |
| D | THR22 |
| D | ALA25 |
| D | SER28 |
| D | ALA29 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide M3L D 27 and SER D 28 |
| Chain | Residue |
| B | GLY4 |
| B | ASP5 |
| B | TYR7 |
| B | TRP29 |
| B | TYR32 |
| B | GLU40 |
| B | HIS44 |
| D | ARG26 |
| D | ALA29 |
| D | PRO30 |
| D | ALA31 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide TYR D 33 and NH2 D 34 |
| Chain | Residue |
| B | THR35 |
| B | ASP37 |
| B | THR38 |
| B | TRP39 |
| C | ALA31 |
| D | THR32 |
Functional Information from PROSITE/UniProt
| site_id | PS00598 |
| Number of Residues | 21 |
| Details | CHROMO_1 Chromo domain signature. YlIRWkGYgsted.TWEPehhL |
| Chain | Residue | Details |
| A | TYR25-LEU45 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Citrulline","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
