6V2J
Crystal structure of ClC-ec1 triple mutant (E113Q, E148Q, E203Q)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005247 | molecular_function | voltage-gated chloride channel activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006821 | biological_process | chloride transport |
A | 0015297 | molecular_function | antiporter activity |
A | 0016020 | cellular_component | membrane |
A | 0042802 | molecular_function | identical protein binding |
A | 0055085 | biological_process | transmembrane transport |
A | 0062158 | molecular_function | chloride:proton antiporter activity |
A | 1902476 | biological_process | chloride transmembrane transport |
A | 1902600 | biological_process | proton transmembrane transport |
A | 1990451 | biological_process | cellular stress response to acidic pH |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue CL A 501 |
Chain | Residue |
A | SER107 |
A | GLY355 |
A | ILE356 |
A | TYR445 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue CL A 502 |
Chain | Residue |
A | SER107 |
A | PRO110 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue CL A 503 |
Chain | Residue |
A | GLY355 |
A | PHE357 |
A | GLY146 |
A | ARG147 |
A | GLN148 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 63 |
Details | TOPO_DOM: Cytoplasmic |
Chain | Residue | Details |
A | MET1-PRO32 | |
A | GLU117-ARG123 | |
A | ARG167-THR176 | |
A | GLU202-SER214 | |
A | ARG282-ASN287 |
site_id | SWS_FT_FI2 |
Number of Residues | 216 |
Details | TRANSMEM: Helical |
Chain | Residue | Details |
A | LEU33-VAL69 | |
A | ILE422-PHE438 | |
A | LEU77-TYR100 | |
A | TRP124-GLY141 | |
A | GLN148-PHE166 | |
A | ILE215-PHE232 | |
A | TRP253-HIS281 | |
A | ILE288-ALA309 | |
A | MET330-SER349 | |
A | GLY355-VAL376 |
site_id | SWS_FT_FI3 |
Number of Residues | 53 |
Details | TOPO_DOM: Periplasmic |
Chain | Residue | Details |
A | HIS70-PRO76 | |
A | ASN233-LEU252 | |
A | PRO310-SER329 | |
A | GLU377-ALA386 |
site_id | SWS_FT_FI4 |
Number of Residues | 52 |
Details | INTRAMEM: Helical |
Chain | Residue | Details |
A | ILE109-LEU116 | |
A | LEU177-ALA189 | |
A | PRO193-ILE201 | |
A | GLY387-SER401 | |
A | PRO405-THR416 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | INTRAMEM: Note=Loop between two helices |
Chain | Residue | Details |
A | ILE402-ALA404 | |
A | ASP417-LEU421 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12649487, ECO:0000305|PubMed:16341087, ECO:0000305|PubMed:18678918, ECO:0007744|PDB:1OTT, ECO:0007744|PDB:1OTU |
Chain | Residue | Details |
A | SER107 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12649487, ECO:0007744|PDB:1OTS, ECO:0007744|PDB:4ENE, ECO:0007744|PDB:6LSC |
Chain | Residue | Details |
A | ILE356 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12649487, ECO:0007744|PDB:1OTT |
Chain | Residue | Details |
A | PHE357 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12649487, ECO:0007744|PDB:1OTS, ECO:0007744|PDB:1OTT, ECO:0007744|PDB:1OTU, ECO:0007744|PDB:4ENE, ECO:0007744|PDB:6LSC |
Chain | Residue | Details |
A | TYR445 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | SITE: Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport |
Chain | Residue | Details |
A | GLN148 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | SITE: Mediates proton transfer from the protein to the inner aqueous phase |
Chain | Residue | Details |
A | GLN203 |