6V2H

Crystal structure of CDYL2 in complex with H3tK27me3

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue NI A 101

Chain	Residue
A	GLY1
A	HIS43
A	HIS44

---

site_id	AC2
Number of Residues	3
Details	binding site for residue NI C 101

Chain	Residue
C	GLY1
C	HIS43
C	HIS44

---

site_id	AC3
Number of Residues	3
Details	binding site for residue NI E 101

Chain	Residue
E	GLY1
E	HIS43
E	HIS44

---

site_id	AC4
Number of Residues	3
Details	binding site for residue NI G 101

Chain	Residue
G	GLY1
G	HIS43
G	HIS44

---

site_id	AC5
Number of Residues	3
Details	binding site for residue NI I 101

Chain	Residue
I	GLY1
I	HIS43
I	HIS44

---

site_id	AC6
Number of Residues	3
Details	binding site for residue NI K 101

Chain	Residue
K	GLY1
K	HIS43
K	HIS44

---

site_id	AC7
Number of Residues	7
Details	binding site for Di-peptide ACE D 20 and ALA D 21

Chain	Residue
C	LEU46
C	HIS47
D	THR22
K	GLU8
L	THR22
L	LYS23
L	VAL24

---

site_id	AC8
Number of Residues	10
Details	binding site for Di-peptide ARG D 26 and M3L D 27

Chain	Residue
C	ALA2
C	SER3
C	GLY4
C	ASP5
C	TRP29
C	GLU36
C	GLU40
C	HIS44
D	ALA25
D	SER28

---

site_id	AC9
Number of Residues	7
Details	binding site for Di-peptide M3L D 27 and SER D 28

Chain	Residue
C	ASP5
C	TRP29
C	GLU36
C	GLU40
C	HIS44
D	ARG26
D	ALA29

---

site_id	AD1
Number of Residues	5
Details	binding site for Di-peptide ACE F 20 and ALA F 21

Chain	Residue
A	GLU8
B	THR22
B	LYS23
E	HIS47
F	THR22

---

site_id	AD2
Number of Residues	11
Details	binding site for Di-peptide ARG F 26 and M3L F 27

Chain	Residue
E	ALA2
E	SER3
E	GLY4
E	ASP5
E	LEU6
E	TRP29
E	TYR32
E	GLU40
E	HIS44
F	ALA25
F	SER28

---

site_id	AD3
Number of Residues	7
Details	binding site for Di-peptide M3L F 27 and SER F 28

Chain	Residue
E	ASP5
E	TRP29
E	TYR32
E	GLU40
E	HIS44
F	ARG26
F	ALA29

---

site_id	AD4
Number of Residues	7
Details	binding site for Di-peptide ACE H 20 and ALA H 21

Chain	Residue
G	LEU46
G	HIS47
H	THR22
I	GLU8
J	THR22
J	LYS23
J	VAL24

---

site_id	AD5
Number of Residues	10
Details	binding site for Di-peptide ARG H 26 and M3L H 27

Chain	Residue
G	ALA2
G	SER3
G	GLY4
G	ASP5
G	TRP29
G	TYR32
G	GLU40
G	HIS44
H	ALA25
H	SER28

---

site_id	AD6
Number of Residues	8
Details	binding site for Di-peptide M3L H 27 and SER H 28

Chain	Residue
G	ASP5
G	TRP29
G	TYR32
G	GLU40
G	HIS44
H	ARG26
H	ALA29
H	PRO30

---

site_id	AD7
Number of Residues	7
Details	binding site for Di-peptide ACE J 20 and ALA J 21

Chain	Residue
G	GLU8
H	THR22
H	LYS23
H	VAL24
I	LEU46
I	HIS47
J	THR22

---

site_id	AD8
Number of Residues	10
Details	binding site for Di-peptide ARG J 26 and M3L J 27

Chain	Residue
I	GLY4
I	ASP5
I	LEU6
I	TYR32
I	GLU40
I	HIS44
J	ALA25
J	SER28
I	ALA2
I	SER3

---

site_id	AD9
Number of Residues	8
Details	binding site for Di-peptide M3L J 27 and SER J 28

Chain	Residue
I	GLY4
I	ASP5
I	TYR32
I	GLU40
I	HIS44
J	ALA25
J	ARG26
J	ALA29

---

site_id	AE1
Number of Residues	7
Details	binding site for Di-peptide ACE L 20 and ALA L 21

Chain	Residue
C	GLU8
D	THR22
D	LYS23
D	VAL24
K	LEU46
K	HIS47
L	THR22

---

site_id	AE2
Number of Residues	9
Details	binding site for Di-peptide ARG L 26 and M3L L 27

Chain	Residue
K	SER3
K	GLY4
K	ASP5
K	TYR7
K	TYR32
K	GLU40
K	HIS44
L	ALA25
L	SER28

---

site_id	AE3
Number of Residues	7
Details	binding site for Di-peptide M3L L 27 and SER L 28

Chain	Residue
K	ASP5
K	TYR7
K	TYR32
K	GLU40
L	ALA25
L	ARG26
L	ALA29

---

Functional Information from PROSITE/UniProt

site_id	PS00598
Number of Residues	21
Details	CHROMO_1 Chromo domain signature. YlIRWkGYgsted.TWEPehhL

Chain	Residue	Details
A	TYR25-LEU45

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708

Chain	Residue	Details
B	LYS23
D	LYS23
F	LYS23
H	LYS23
J	LYS23
L	LYS23

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Citrulline => ECO:0000269|PubMed:16567635

Chain	Residue	Details
B	ARG26
D	ARG26
F	ARG26
H	ARG26
J	ARG26
L	ARG26

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708

Chain	Residue	Details
B	M3L27
D	M3L27
F	M3L27
H	M3L27
J	M3L27
L	M3L27

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588

Chain	Residue	Details
B	SER28
D	SER28
F	SER28
H	SER28
J	SER28
L	SER28

---