6UXJ
Structure of serine hydroxymethyltransferase 8 from Glycine max cultivar Essex complexed with PLP-glycine and 5-formyltetrahydrofolate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0019264 | biological_process | glycine biosynthetic process from serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| B | 0019264 | biological_process | glycine biosynthetic process from serine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| C | 0019264 | biological_process | glycine biosynthetic process from serine |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
| D | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| D | 0019264 | biological_process | glycine biosynthetic process from serine |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue PLG A 501 |
| Chain | Residue |
| A | SER39 |
| A | HIS218 |
| A | THR241 |
| A | HIS243 |
| A | LYS244 |
| A | ARG389 |
| A | FFO502 |
| B | TYR59 |
| B | TYR69 |
| B | GLY289 |
| B | GLY290 |
| A | SER105 |
| B | HOH610 |
| B | HOH803 |
| A | GLY106 |
| A | SER107 |
| A | HIS134 |
| A | GLY189 |
| A | SER190 |
| A | ASP215 |
| A | ALA217 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | binding site for residue FFO A 502 |
| Chain | Residue |
| A | LEU129 |
| A | GLY132 |
| A | GLY133 |
| A | HIS134 |
| A | LEU135 |
| A | TYR139 |
| A | SER190 |
| A | ALA191 |
| A | ASN374 |
| A | ALA382 |
| A | PLG501 |
| A | EDO503 |
| A | HOH607 |
| A | HOH628 |
| A | HOH639 |
| A | HOH666 |
| A | HOH692 |
| A | HOH776 |
| A | HOH893 |
| B | GLU61 |
| B | TYR68 |
| B | TYR69 |
| B | PHE281 |
| B | PRO285 |
| B | HOH610 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | LYS373 |
| A | LEU383 |
| A | FFO502 |
| B | ASN66 |
| B | ARG67 |
| B | TYR68 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | ASN66 |
| A | ARG67 |
| A | TYR68 |
| A | HOH612 |
| B | LYS373 |
| B | LEU383 |
| B | FFO502 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | ARG123 |
| A | PHE180 |
| A | ARG181 |
| A | HOH648 |
| A | HOH732 |
| C | TYR140 |
| C | LYS146 |
| C | HOH1173 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | GLY52 |
| A | HOH680 |
| A | HOH691 |
| A | HOH716 |
| B | ILE48 |
| B | GLY52 |
| B | HOH793 |
| site_id | AC7 |
| Number of Residues | 21 |
| Details | binding site for residue PLG B 501 |
| Chain | Residue |
| A | TYR59 |
| A | TYR69 |
| A | GLY289 |
| A | GLY290 |
| A | HOH625 |
| A | HOH796 |
| B | SER39 |
| B | SER105 |
| B | GLY106 |
| B | SER107 |
| B | HIS134 |
| B | GLY189 |
| B | SER190 |
| B | ASP215 |
| B | ALA217 |
| B | HIS218 |
| B | THR241 |
| B | HIS243 |
| B | LYS244 |
| B | ARG389 |
| B | FFO502 |
| site_id | AC8 |
| Number of Residues | 27 |
| Details | binding site for residue FFO B 502 |
| Chain | Residue |
| A | EDO504 |
| A | HOH625 |
| B | LEU129 |
| B | GLY132 |
| B | GLY133 |
| B | HIS134 |
| B | LEU135 |
| B | TYR139 |
| B | SER190 |
| B | ALA191 |
| B | ASN372 |
| B | ASN374 |
| B | ALA382 |
| B | PLG501 |
| B | HOH609 |
| B | HOH612 |
| B | HOH624 |
| B | HOH645 |
| B | HOH667 |
| B | HOH674 |
| B | HOH764 |
| B | HOH776 |
| B | HOH796 |
| A | GLU61 |
| A | TYR68 |
| A | TYR69 |
| A | PHE281 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | TYR140 |
| B | THR141 |
| B | SER142 |
| B | HOH636 |
| B | HOH665 |
| D | ASP179 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | ARG123 |
| B | PHE180 |
| B | ARG181 |
| B | HOH649 |
| B | HOH744 |
| D | TYR140 |
| D | LYS146 |
| D | HOH1073 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| A | PHE111 |
| B | PHE111 |
| B | HOH688 |
| B | HOH741 |
| B | HOH858 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 801 |
| Chain | Residue |
| A | ASP128 |
| A | TYR140 |
| A | THR141 |
| A | SER142 |
| C | LEU178 |
| C | ASP179 |
| C | HOH922 |
| site_id | AD4 |
| Number of Residues | 21 |
| Details | binding site for residue PLG C 802 |
| Chain | Residue |
| C | SER39 |
| C | SER105 |
| C | GLY106 |
| C | SER107 |
| C | HIS134 |
| C | GLY189 |
| C | SER190 |
| C | ASP215 |
| C | ALA217 |
| C | HIS218 |
| C | THR241 |
| C | HIS243 |
| C | LYS244 |
| C | ARG389 |
| C | FFO803 |
| D | TYR59 |
| D | TYR69 |
| D | GLY289 |
| D | GLY290 |
| D | HOH810 |
| D | HOH989 |
| site_id | AD5 |
| Number of Residues | 27 |
| Details | binding site for residue FFO C 803 |
| Chain | Residue |
| C | LEU129 |
| C | GLY132 |
| C | GLY133 |
| C | HIS134 |
| C | LEU135 |
| C | TYR139 |
| C | SER190 |
| C | ALA191 |
| C | ASN374 |
| C | ALA382 |
| C | PLG802 |
| C | HOH924 |
| C | HOH939 |
| C | HOH948 |
| C | HOH953 |
| C | HOH984 |
| C | HOH986 |
| C | HOH1021 |
| C | HOH1157 |
| C | HOH1163 |
| D | GLU61 |
| D | TYR68 |
| D | TYR69 |
| D | PHE281 |
| D | PRO285 |
| D | EDO702 |
| D | HOH810 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO C 804 |
| Chain | Residue |
| A | TYR140 |
| A | LYS146 |
| A | HOH702 |
| C | ARG123 |
| C | PHE180 |
| C | ARG181 |
| C | HOH1099 |
| C | HOH1170 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 805 |
| Chain | Residue |
| A | LEU178 |
| A | ASP179 |
| C | TYR140 |
| C | SER142 |
| C | LYS160 |
| C | HOH913 |
| C | HOH1024 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 806 |
| Chain | Residue |
| C | PHE111 |
| C | HOH1004 |
| C | HOH1135 |
| C | HOH1177 |
| D | PHE111 |
| D | HOH961 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 807 |
| Chain | Residue |
| C | HOH1042 |
| C | HOH1140 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO D 701 |
| Chain | Residue |
| B | TYR140 |
| B | LYS146 |
| B | HOH863 |
| D | ARG123 |
| D | PHE180 |
| D | ARG181 |
| D | HOH829 |
| D | HOH953 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO D 702 |
| Chain | Residue |
| C | LYS373 |
| C | ALA382 |
| C | LEU383 |
| C | FFO803 |
| D | ASN66 |
| D | ARG67 |
| D | TYR68 |
| D | HOH841 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO D 703 |
| Chain | Residue |
| C | ILE48 |
| C | GLY52 |
| C | HOH934 |
| C | HOH1014 |
| D | ILE48 |
| D | GLY52 |
| D | HOH881 |
| D | HOH1003 |
| site_id | AE4 |
| Number of Residues | 21 |
| Details | binding site for residue PLG D 704 |
| Chain | Residue |
| C | TYR59 |
| C | TYR69 |
| C | GLY289 |
| C | GLY290 |
| C | HOH928 |
| C | HOH1103 |
| D | SER39 |
| D | SER105 |
| D | GLY106 |
| D | SER107 |
| D | HIS134 |
| D | GLY189 |
| D | SER190 |
| D | ASP215 |
| D | ALA217 |
| D | HIS218 |
| D | THR241 |
| D | HIS243 |
| D | LYS244 |
| D | ARG389 |
| D | FFO705 |
| site_id | AE5 |
| Number of Residues | 24 |
| Details | binding site for residue FFO D 705 |
| Chain | Residue |
| C | GLU61 |
| C | TYR68 |
| C | TYR69 |
| C | PHE281 |
| D | LEU129 |
| D | GLY132 |
| D | GLY133 |
| D | HIS134 |
| D | LEU135 |
| D | TYR139 |
| D | SER190 |
| D | ALA191 |
| D | ASN374 |
| D | ALA382 |
| D | PLG704 |
| D | EDO706 |
| D | HOH817 |
| D | HOH836 |
| D | HOH840 |
| D | HOH888 |
| D | HOH891 |
| D | HOH902 |
| D | HOH932 |
| D | HOH1002 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 706 |
| Chain | Residue |
| C | ASN66 |
| C | ARG67 |
| C | TYR68 |
| D | LYS373 |
| D | FFO705 |
| D | HOH902 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 707 |
| Chain | Residue |
| B | ASP179 |
| D | ASP128 |
| D | TYR140 |
| D | THR141 |
| D | SER142 |
| D | HOH825 |
| D | HOH831 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DIvTTTTHKSLrGPRAG |
| Chain | Residue | Details |
| A | ASP236-GLY252 |
