6US5

DNA polymerase I Large Fragment from Bacillus stearothermophilus with DNA template, 3'-amino primer, dGpNHpp analog, and Mn2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0004518	molecular_function	nuclease activity
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair
A	0006302	biological_process	double-strand break repair
A	0006974	biological_process	DNA damage response
A	0008408	molecular_function	3'-5' exonuclease activity
A	0046872	molecular_function	metal ion binding
A	0071897	biological_process	DNA biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0004518	molecular_function	nuclease activity
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006281	biological_process	DNA repair
D	0006302	biological_process	double-strand break repair
D	0006974	biological_process	DNA damage response
D	0008408	molecular_function	3'-5' exonuclease activity
D	0046872	molecular_function	metal ion binding
D	0071897	biological_process	DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue XG4 A 901

Chain	Residue
A	ARG615
A	ASP830
A	MN902
A	HOH1105
A	HOH1123
A	HOH1144
B	C429
C	DC3
C	DG4
A	TYR654
A	GLN656
A	GLU658
A	HIS682
A	ARG702
A	LYS706
A	TYR710
A	TYR714

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site_id	AC2
Number of Residues	3
Details	binding site for residue MN A 902

Chain	Residue
A	TYR654
A	ASP830
A	XG4901

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site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 903

Chain	Residue
A	MET299
A	ALA300
A	ARG343
A	ARG677
A	SO4905

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site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 904

Chain	Residue
A	ARG306
A	THR308
A	GLU309

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 905

Chain	Residue
A	ASN670
A	SO4903

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 906

Chain	Residue
A	ARG423
A	PRO424
D	ARG779
D	ASN780

---

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 C 101

Chain	Residue
B	DC2
C	DC10

---

site_id	AC8
Number of Residues	16
Details	binding site for residue XG4 D 901

Chain	Residue
D	ARG615
D	ASP653
D	TYR654
D	GLN656
D	ILE657
D	GLU658
D	HIS682
D	ARG702
D	LYS706
D	TYR710
D	TYR714
D	ASP830
D	MN902
E	C429
F	DC3
F	DG4

---

site_id	AC9
Number of Residues	4
Details	binding site for residue MN D 902

Chain	Residue
D	ASP653
D	TYR654
D	ASP830
D	XG4901

---

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 D 903

Chain	Residue
D	ARG306
D	THR308
D	GLU309

---

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 D 904

Chain	Residue
D	GLU321
D	VAL322
D	ARG375
D	ASP425
D	LYS450
D	HOH1033

---

site_id	AD3
Number of Residues	19
Details	binding site for Di-nucleotide DG E 8 and C42 E 9

Chain	Residue
D	ARG615
D	GLN624
D	ASN625
D	ILE626
D	PRO627
D	ILE628
D	ARG629
D	ARG637
D	VAL828
D	HIS829
D	ASP830
D	GLU831
D	XG4901
D	HOH1008
D	HOH1045
E	DA7
F	DG4
F	DC5
F	DT6

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Functional Information from PROSITE/UniProt

site_id	PS00447
Number of Residues	20
Details	DNA_POLYMERASE_A DNA polymerase family A signature. RrqAKavnYGivYgiSdygL

Chain	Residue	Details
A	ARG702-LEU721

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