6URQ

Complex structure of human poly-ADP-ribosyltransferase TNKS1 ARC2-ARC3 and P antigen family member 4 (PAGE4)

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0003713	molecular_function	transcription coactivator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0032872	biological_process	regulation of stress-activated MAPK cascade
C	0035556	biological_process	intracellular signal transduction
C	0042594	biological_process	response to starvation
C	0043066	biological_process	negative regulation of apoptotic process
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0003713	molecular_function	transcription coactivator activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0032872	biological_process	regulation of stress-activated MAPK cascade
D	0035556	biological_process	intracellular signal transduction
D	0042594	biological_process	response to starvation
D	0043066	biological_process	negative regulation of apoptotic process
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 701

Chain	Residue
A	LYS536
A	HOH868
B	LYS517
B	ASN550
B	GLU553
B	HOH919

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site_id	AC2
Number of Residues	4
Details	binding site for residue GOL B 701

Chain	Residue
B	HOH935
B	LYS583
B	MET584
B	ASN585

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: Phosphoserine; by CLK2 => ECO:0000269|PubMed:28289210

Chain	Residue	Details
C	SER7
C	SER73
C	SER79
D	SER7
D	SER73
D	SER79

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by HIPK1 and CLK2 => ECO:0000269|PubMed:26242913, ECO:0000269|PubMed:28289210

Chain	Residue	Details
C	SER9
D	SER9

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by HIPK1 and CLK2 => ECO:0000269|PubMed:24559171, ECO:0000269|PubMed:26242913, ECO:0000269|PubMed:28289210, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	THR51
D	THR51

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site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by CLK2 => ECO:0000269|PubMed:28289210

Chain	Residue	Details
C	THR71
C	THR85
C	THR94
D	THR71
D	THR85
D	THR94

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