6URO
Cryo-EM structure of human CPSF160-WDR33-CPSF30-PAS RNA-CstF77 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005847 | cellular_component | mRNA cleavage and polyadenylation specificity factor complex |
| A | 0006397 | biological_process | mRNA processing |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0035925 | molecular_function | mRNA 3'-UTR AU-rich region binding |
| A | 0180012 | biological_process | co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway |
| B | 0031124 | biological_process | mRNA 3'-end processing |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003723 | molecular_function | RNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005847 | cellular_component | mRNA cleavage and polyadenylation specificity factor complex |
| C | 0006397 | biological_process | mRNA processing |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0046872 | molecular_function | metal ion binding |
| C | 1990837 | molecular_function | sequence-specific double-stranded DNA binding |
| E | 0003723 | molecular_function | RNA binding |
| E | 0003729 | molecular_function | mRNA binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005848 | cellular_component | mRNA cleavage stimulating factor complex |
| E | 0006396 | biological_process | RNA processing |
| E | 0006397 | biological_process | mRNA processing |
| E | 0031123 | biological_process | RNA 3'-end processing |
| E | 0031124 | biological_process | mRNA 3'-end processing |
| E | 0180010 | biological_process | co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway |
| F | 0003723 | molecular_function | RNA binding |
| F | 0003729 | molecular_function | mRNA binding |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005654 | cellular_component | nucleoplasm |
| F | 0005848 | cellular_component | mRNA cleavage stimulating factor complex |
| F | 0006396 | biological_process | RNA processing |
| F | 0006397 | biological_process | mRNA processing |
| F | 0031123 | biological_process | RNA 3'-end processing |
| F | 0031124 | biological_process | mRNA 3'-end processing |
| F | 0180010 | biological_process | co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue ZN C 301 |
| Chain | Residue |
| C | CYS41 |
| C | CYS55 |
| C | HIS59 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 302 |
| Chain | Residue |
| C | CYS68 |
| C | TRP71 |
| C | CYS76 |
| C | CYS82 |
| C | HIS86 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 303 |
| Chain | Residue |
| C | CYS105 |
| C | CYS110 |
| C | HIS114 |
| C | CYS96 |
Functional Information from PROSITE/UniProt
| site_id | PS00213 |
| Number of Residues | 13 |
| Details | LIPOCALIN Lipocalin signature. EVKl.NLNGNWLLT |
| Chain | Residue | Details |
| B | GLU293-THR305 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| E | SER2 | |
| F | SER2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| E | SER691 | |
| F | SER691 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 27 |
| Details | ZN_FING: C3H1-type 3 => ECO:0000255|PROSITE-ProRule:PRU00723 |
| Chain | Residue | Details |
| C | MET90-PRO117 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | ZN_FING: C3H1-type 4 => ECO:0000255|PROSITE-ProRule:PRU00723 |
| Chain | Residue | Details |
| C | GLU118-HIS142 | |
| B | LYS560 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 26 |
| Details | ZN_FING: C3H1-type 5 => ECO:0000255|PROSITE-ProRule:PRU00723 |
| Chain | Residue | Details |
| C | THR143-PHE169 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | MET200 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| C | SER202 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | PRO212 |
