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6URI

HIV-1 Nef in complex with the CD4 cytoplasmic domain and the AP2 clathrin adaptor complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005794cellular_componentGolgi apparatus
A0006886biological_processintracellular protein transport
A0016192biological_processvesicle-mediated transport
A0030117cellular_componentmembrane coat
A0030121cellular_componentAP-1 adaptor complex
B0006886biological_processintracellular protein transport
B0015031biological_processprotein transport
B0016192biological_processvesicle-mediated transport
B0030117cellular_componentmembrane coat
B0030276molecular_functionclathrin binding
M0006886biological_processintracellular protein transport
M0016192biological_processvesicle-mediated transport
M0030131cellular_componentclathrin adaptor complex
N0005525molecular_functionGTP binding
S0005515molecular_functionprotein binding
S0005737cellular_componentcytoplasm
S0005829cellular_componentcytosol
S0005886cellular_componentplasma membrane
S0005905cellular_componentclathrin-coated pit
S0006886biological_processintracellular protein transport
S0006897biological_processendocytosis
S0009898cellular_componentcytoplasmic side of plasma membrane
S0015031biological_processprotein transport
S0016192biological_processvesicle-mediated transport
S0030100biological_processregulation of endocytosis
S0030117cellular_componentmembrane coat
S0030122cellular_componentAP-2 adaptor complex
S0030666cellular_componentendocytic vesicle membrane
S0030669cellular_componentclathrin-coated endocytic vesicle membrane
S0035615molecular_functionclathrin adaptor activity
S0036020cellular_componentendolysosome membrane
S0043231cellular_componentintracellular membrane-bounded organelle
S0045202cellular_componentsynapse
S0045334cellular_componentclathrin-coated endocytic vesicle
S0048268biological_processclathrin coat assembly
S0048488biological_processsynaptic vesicle endocytosis
S0071944cellular_componentcell periphery
S0072583biological_processclathrin-dependent endocytosis
S0098793cellular_componentpresynapse
S0098794cellular_componentpostsynapse
S0098884biological_processpostsynaptic neurotransmitter receptor internalization
Functional Information from PROSITE/UniProt
site_idPS00989
Number of Residues11
DetailsCLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF
ChainResidueDetails
SILE57-PHE67

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by viral protease => ECO:0000255|HAMAP-Rule:MF_04078, ECO:0000269|PubMed:7835426
ChainResidueDetails
NTRP57
DSER415
ATYR53
ALYS57

site_idSWS_FT_FI2
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:1618861
ChainResidueDetails
DCYS394
DCYS397

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS265

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PDB entries from 2024-05-01

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