6UPR
Crystal Structure of GTPase Domain of Human Septin 2 / Septin 8 Heterocomplex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue GDP A 1401 |
| Chain | Residue |
| A | GLY47 |
| A | VAL240 |
| A | GLY241 |
| A | ARG256 |
| A | TYR258 |
| A | HOH1519 |
| A | HOH1528 |
| B | THR160 |
| B | HIS162 |
| B | THR190 |
| B | GLU195 |
| A | LEU48 |
| A | GLY49 |
| A | LYS50 |
| A | SER51 |
| A | THR52 |
| A | ARG66 |
| A | LYS183 |
| A | ASP185 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue GTP B 401 |
| Chain | Residue |
| A | HIS158 |
| A | THR186 |
| A | GLU191 |
| A | HOH1533 |
| B | THR53 |
| B | GLY54 |
| B | ILE55 |
| B | GLY56 |
| B | LYS57 |
| B | SER58 |
| B | THR59 |
| B | ALA74 |
| B | LYS187 |
| B | ASP189 |
| B | VAL240 |
| B | GLY241 |
| B | ARG256 |
| B | TYR258 |
| B | MG402 |
| B | HOH502 |
| B | HOH508 |
| B | HOH509 |
| B | HOH513 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | SER58 |
| B | THR71 |
| B | GTP401 |
| B | HOH502 |
| B | HOH508 |
| B | HOH513 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01056","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01056","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01056","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Region: {"description":"Important for dimerization"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for dimerization"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15150837","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19165576","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18088087","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18318008","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
