6UO7

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with AR-42

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0004407	molecular_function	histone deacetylase activity
A	0006325	biological_process	chromatin organization
A	0016575	biological_process	histone deacetylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	ASP230
A	HIS232
A	ASP323
A	QCP504

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site_id	AC2
Number of Residues	6
Details	binding site for residue K A 502

Chain	Residue
A	HOH711
A	PHE241
A	ASP244
A	VAL247
A	TYR280
A	HOH668

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site_id	AC3
Number of Residues	5
Details	binding site for residue K A 503

Chain	Residue
A	ASP228
A	ASP230
A	HIS232
A	SER251
A	VAL252

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site_id	AC4
Number of Residues	15
Details	binding site for residue QCP A 504

Chain	Residue
A	HIS82
A	PRO83
A	GLU94
A	SER150
A	HIS192
A	HIS193
A	PHE202
A	ASP230
A	HIS232
A	TRP261
A	ASP323
A	TYR363
A	ZN501
A	HOH716
A	HOH748

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