6U90

Crystal structure of DNMT3B(N779A)-DNMT3L in complex with CpGpT DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
D	0008168	molecular_function	methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 901

Chain	Residue
A	VAL719
A	MET720
A	ASN743
A	ARG744
A	VAL746

---

site_id	AC2
Number of Residues	16
Details	binding site for residue SAH A 902

Chain	Residue
A	THR586
A	GLU605
A	VAL606
A	CYS607
A	ASP627
A	VAL628
A	GLY648
A	LEU671
A	ARG832
A	SER833
A	TRP834
A	HOH1010
A	PHE581
A	ASP582
A	GLY583
A	ILE584

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL D 901

Chain	Residue
D	MET720
D	ILE721
D	LYS725
D	ASN743
D	ARG744

---

site_id	AC4
Number of Residues	16
Details	binding site for residue SAH D 902

Chain	Residue
D	PHE581
D	ASP582
D	GLY583
D	ILE584
D	THR586
D	SER604
D	GLU605
D	VAL606
D	CYS607
D	ASP627
D	VAL628
D	GLY648
D	LEU671
D	ARG832
D	SER833
D	TRP834

---

site_id	AC5
Number of Residues	16
Details	binding site for Di-nucleotide DG E 426 and PYO E 427

Chain	Residue
D	SER649
D	CYS651
D	SER655
D	ASN656
D	GLU697
D	VAL699
D	ARG731
D	ARG733
D	GLN772
D	THR773
D	GLY831
D	ARG832
E	DT425
E	DG428
F	DG442
F	DC443

---

site_id	AC6
Number of Residues	17
Details	binding site for Di-peptide PYO E 427 and CYS D 651

Chain	Residue
D	SER649
D	PRO650
D	ASN652
D	ASP653
D	LEU654
D	SER655
D	GLU697
D	ASN698
D	VAL699
D	ARG731
D	ARG733
D	THR773
D	GLY831
D	ARG832
D	HOH1001
E	DG426
E	DG428

---

site_id	AC7
Number of Residues	18
Details	binding site for Di-nucleotide PYO E 427 and DG E 428

Chain	Residue
D	SER649
D	CYS651
D	ASN652
D	SER655
D	VAL657
D	ASN658
D	PRO659
D	GLU697
D	VAL699
D	ARG731
D	ARG733
D	THR773
D	THR776
D	GLY831
D	ARG832
E	DG426
E	DT429
F	DC441

---

site_id	AC8
Number of Residues	19
Details	binding site for Di-nucleotide DG F 426 and PYO F 427

Chain	Residue
A	VAL699
A	ARG731
A	ARG733
A	GLN772
A	THR773
A	THR775
A	THR776
A	GLY831
A	ARG832
E	DG442
E	DC443
F	DT425
F	DG428
A	SER649
A	CYS651
A	SER655
A	ASN656
A	VAL657
A	GLU697

---

site_id	AC9
Number of Residues	20
Details	binding site for Di-nucleotide PYO F 427 and DG F 428

Chain	Residue
A	SER649
A	CYS651
A	ASN652
A	SER655
A	VAL657
A	ASN658
A	PRO659
A	GLU697
A	VAL699
A	ARG731
A	ARG733
A	THR773
A	THR775
A	THR776
A	GLY831
A	ARG832
E	DC441
E	DG442
F	DG426
F	DT429

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS

Chain	Residue	Details
A	ASP643-SER655

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018

Chain	Residue	Details
D	CYS651
A	CYS651

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9Y6K1

Chain	Residue	Details
A	ASP627
A	ARG832
D	ASP582
D	GLU605
D	ASP627
D	ARG832
A	GLU605
A	ASP582

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
D	LYS617
A	LYS617

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