6U39

2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000922	cellular_component	spindle pole
A	0002027	biological_process	regulation of heart rate
A	0005246	molecular_function	calcium channel regulator activity
A	0005509	molecular_function	calcium ion binding
A	0005513	biological_process	detection of calcium ion
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005876	cellular_component	spindle microtubule
A	0005886	cellular_component	plasma membrane
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0010856	molecular_function	adenylate cyclase activator activity
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0016240	biological_process	autophagosome membrane docking
A	0019855	molecular_function	calcium channel inhibitor activity
A	0019901	molecular_function	protein kinase binding
A	0021762	biological_process	substantia nigra development
A	0030017	cellular_component	sarcomere
A	0031432	molecular_function	titin binding
A	0031514	cellular_component	motile cilium
A	0031982	cellular_component	vesicle
A	0032465	biological_process	regulation of cytokinesis
A	0032991	cellular_component	protein-containing complex
A	0034704	cellular_component	calcium channel complex
A	0035458	biological_process	cellular response to interferon-beta
A	0043209	cellular_component	myelin sheath
A	0043539	molecular_function	protein serine/threonine kinase activator activity
A	0044305	cellular_component	calyx of Held
A	0044325	molecular_function	transmembrane transporter binding
A	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0051592	biological_process	response to calcium ion
A	0055117	biological_process	regulation of cardiac muscle contraction
A	0060291	biological_process	long-term synaptic potentiation
A	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
A	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
A	0071346	biological_process	cellular response to type II interferon
A	0072542	molecular_function	protein phosphatase activator activity
A	0097225	cellular_component	sperm midpiece
A	0097720	biological_process	calcineurin-mediated signaling
A	0098901	biological_process	regulation of cardiac muscle cell action potential
A	0099523	cellular_component	presynaptic cytosol
A	0140056	biological_process	organelle localization by membrane tethering
A	0140238	biological_process	presynaptic endocytosis
A	0141110	molecular_function	transporter inhibitor activity
A	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
A	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
A	1902494	cellular_component	catalytic complex
A	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
A	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
C	0000922	cellular_component	spindle pole
C	0002027	biological_process	regulation of heart rate
C	0005246	molecular_function	calcium channel regulator activity
C	0005509	molecular_function	calcium ion binding
C	0005513	biological_process	detection of calcium ion
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005876	cellular_component	spindle microtubule
C	0005886	cellular_component	plasma membrane
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0010856	molecular_function	adenylate cyclase activator activity
C	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0016020	cellular_component	membrane
C	0016240	biological_process	autophagosome membrane docking
C	0019855	molecular_function	calcium channel inhibitor activity
C	0019901	molecular_function	protein kinase binding
C	0021762	biological_process	substantia nigra development
C	0030017	cellular_component	sarcomere
C	0031432	molecular_function	titin binding
C	0031514	cellular_component	motile cilium
C	0031982	cellular_component	vesicle
C	0032465	biological_process	regulation of cytokinesis
C	0032991	cellular_component	protein-containing complex
C	0034704	cellular_component	calcium channel complex
C	0035458	biological_process	cellular response to interferon-beta
C	0043209	cellular_component	myelin sheath
C	0043539	molecular_function	protein serine/threonine kinase activator activity
C	0044305	cellular_component	calyx of Held
C	0044325	molecular_function	transmembrane transporter binding
C	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0051592	biological_process	response to calcium ion
C	0055117	biological_process	regulation of cardiac muscle contraction
C	0060291	biological_process	long-term synaptic potentiation
C	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
C	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
C	0071346	biological_process	cellular response to type II interferon
C	0072542	molecular_function	protein phosphatase activator activity
C	0097225	cellular_component	sperm midpiece
C	0097720	biological_process	calcineurin-mediated signaling
C	0098901	biological_process	regulation of cardiac muscle cell action potential
C	0099523	cellular_component	presynaptic cytosol
C	0140056	biological_process	organelle localization by membrane tethering
C	0140238	biological_process	presynaptic endocytosis
C	0141110	molecular_function	transporter inhibitor activity
C	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
C	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
C	1902494	cellular_component	catalytic complex
C	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
C	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
E	0000922	cellular_component	spindle pole
E	0002027	biological_process	regulation of heart rate
E	0005246	molecular_function	calcium channel regulator activity
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005876	cellular_component	spindle microtubule
E	0005886	cellular_component	plasma membrane
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016240	biological_process	autophagosome membrane docking
E	0019855	molecular_function	calcium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0021762	biological_process	substantia nigra development
E	0030017	cellular_component	sarcomere
E	0031432	molecular_function	titin binding
E	0031514	cellular_component	motile cilium
E	0031982	cellular_component	vesicle
E	0032465	biological_process	regulation of cytokinesis
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0035458	biological_process	cellular response to interferon-beta
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0044305	cellular_component	calyx of Held
E	0044325	molecular_function	transmembrane transporter binding
E	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060291	biological_process	long-term synaptic potentiation
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
E	0071346	biological_process	cellular response to type II interferon
E	0072542	molecular_function	protein phosphatase activator activity
E	0097225	cellular_component	sperm midpiece
E	0097720	biological_process	calcineurin-mediated signaling
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0099523	cellular_component	presynaptic cytosol
E	0140056	biological_process	organelle localization by membrane tethering
E	0140238	biological_process	presynaptic endocytosis
E	0141110	molecular_function	transporter inhibitor activity
E	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
E	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
E	1902494	cellular_component	catalytic complex
E	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
E	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
G	0000922	cellular_component	spindle pole
G	0002027	biological_process	regulation of heart rate
G	0005246	molecular_function	calcium channel regulator activity
G	0005509	molecular_function	calcium ion binding
G	0005513	biological_process	detection of calcium ion
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0005876	cellular_component	spindle microtubule
G	0005886	cellular_component	plasma membrane
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0010856	molecular_function	adenylate cyclase activator activity
G	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G	0016020	cellular_component	membrane
G	0016240	biological_process	autophagosome membrane docking
G	0019855	molecular_function	calcium channel inhibitor activity
G	0019901	molecular_function	protein kinase binding
G	0021762	biological_process	substantia nigra development
G	0030017	cellular_component	sarcomere
G	0031432	molecular_function	titin binding
G	0031514	cellular_component	motile cilium
G	0031982	cellular_component	vesicle
G	0032465	biological_process	regulation of cytokinesis
G	0032991	cellular_component	protein-containing complex
G	0034704	cellular_component	calcium channel complex
G	0035458	biological_process	cellular response to interferon-beta
G	0043209	cellular_component	myelin sheath
G	0043539	molecular_function	protein serine/threonine kinase activator activity
G	0044305	cellular_component	calyx of Held
G	0044325	molecular_function	transmembrane transporter binding
G	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
G	0046872	molecular_function	metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0051592	biological_process	response to calcium ion
G	0055117	biological_process	regulation of cardiac muscle contraction
G	0060291	biological_process	long-term synaptic potentiation
G	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
G	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
G	0071346	biological_process	cellular response to type II interferon
G	0072542	molecular_function	protein phosphatase activator activity
G	0097225	cellular_component	sperm midpiece
G	0097720	biological_process	calcineurin-mediated signaling
G	0098901	biological_process	regulation of cardiac muscle cell action potential
G	0099523	cellular_component	presynaptic cytosol
G	0140056	biological_process	organelle localization by membrane tethering
G	0140238	biological_process	presynaptic endocytosis
G	0141110	molecular_function	transporter inhibitor activity
G	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
G	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
G	1902494	cellular_component	catalytic complex
G	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
G	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
I	0000922	cellular_component	spindle pole
I	0002027	biological_process	regulation of heart rate
I	0005246	molecular_function	calcium channel regulator activity
I	0005509	molecular_function	calcium ion binding
I	0005513	biological_process	detection of calcium ion
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005813	cellular_component	centrosome
I	0005819	cellular_component	spindle
I	0005829	cellular_component	cytosol
I	0005876	cellular_component	spindle microtubule
I	0005886	cellular_component	plasma membrane
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0008076	cellular_component	voltage-gated potassium channel complex
I	0010856	molecular_function	adenylate cyclase activator activity
I	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I	0016020	cellular_component	membrane
I	0016240	biological_process	autophagosome membrane docking
I	0019855	molecular_function	calcium channel inhibitor activity
I	0019901	molecular_function	protein kinase binding
I	0021762	biological_process	substantia nigra development
I	0030017	cellular_component	sarcomere
I	0031432	molecular_function	titin binding
I	0031514	cellular_component	motile cilium
I	0031982	cellular_component	vesicle
I	0032465	biological_process	regulation of cytokinesis
I	0032991	cellular_component	protein-containing complex
I	0034704	cellular_component	calcium channel complex
I	0035458	biological_process	cellular response to interferon-beta
I	0043209	cellular_component	myelin sheath
I	0043539	molecular_function	protein serine/threonine kinase activator activity
I	0044305	cellular_component	calyx of Held
I	0044325	molecular_function	transmembrane transporter binding
I	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
I	0046872	molecular_function	metal ion binding
I	0048306	molecular_function	calcium-dependent protein binding
I	0051592	biological_process	response to calcium ion
I	0055117	biological_process	regulation of cardiac muscle contraction
I	0060291	biological_process	long-term synaptic potentiation
I	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
I	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
I	0071346	biological_process	cellular response to type II interferon
I	0072542	molecular_function	protein phosphatase activator activity
I	0097225	cellular_component	sperm midpiece
I	0097720	biological_process	calcineurin-mediated signaling
I	0098901	biological_process	regulation of cardiac muscle cell action potential
I	0099523	cellular_component	presynaptic cytosol
I	0140056	biological_process	organelle localization by membrane tethering
I	0140238	biological_process	presynaptic endocytosis
I	0141110	molecular_function	transporter inhibitor activity
I	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
I	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
I	1902494	cellular_component	catalytic complex
I	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
I	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
K	0000922	cellular_component	spindle pole
K	0002027	biological_process	regulation of heart rate
K	0005246	molecular_function	calcium channel regulator activity
K	0005509	molecular_function	calcium ion binding
K	0005513	biological_process	detection of calcium ion
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005876	cellular_component	spindle microtubule
K	0005886	cellular_component	plasma membrane
K	0007186	biological_process	G protein-coupled receptor signaling pathway
K	0008076	cellular_component	voltage-gated potassium channel complex
K	0010856	molecular_function	adenylate cyclase activator activity
K	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K	0016020	cellular_component	membrane
K	0016240	biological_process	autophagosome membrane docking
K	0019855	molecular_function	calcium channel inhibitor activity
K	0019901	molecular_function	protein kinase binding
K	0021762	biological_process	substantia nigra development
K	0030017	cellular_component	sarcomere
K	0031432	molecular_function	titin binding
K	0031514	cellular_component	motile cilium
K	0031982	cellular_component	vesicle
K	0032465	biological_process	regulation of cytokinesis
K	0032991	cellular_component	protein-containing complex
K	0034704	cellular_component	calcium channel complex
K	0035458	biological_process	cellular response to interferon-beta
K	0043209	cellular_component	myelin sheath
K	0043539	molecular_function	protein serine/threonine kinase activator activity
K	0044305	cellular_component	calyx of Held
K	0044325	molecular_function	transmembrane transporter binding
K	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
K	0046872	molecular_function	metal ion binding
K	0048306	molecular_function	calcium-dependent protein binding
K	0051592	biological_process	response to calcium ion
K	0055117	biological_process	regulation of cardiac muscle contraction
K	0060291	biological_process	long-term synaptic potentiation
K	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
K	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
K	0071346	biological_process	cellular response to type II interferon
K	0072542	molecular_function	protein phosphatase activator activity
K	0097225	cellular_component	sperm midpiece
K	0097720	biological_process	calcineurin-mediated signaling
K	0098901	biological_process	regulation of cardiac muscle cell action potential
K	0099523	cellular_component	presynaptic cytosol
K	0140056	biological_process	organelle localization by membrane tethering
K	0140238	biological_process	presynaptic endocytosis
K	0141110	molecular_function	transporter inhibitor activity
K	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
K	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
K	1902494	cellular_component	catalytic complex
K	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
K	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
M	0000922	cellular_component	spindle pole
M	0002027	biological_process	regulation of heart rate
M	0005246	molecular_function	calcium channel regulator activity
M	0005509	molecular_function	calcium ion binding
M	0005513	biological_process	detection of calcium ion
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005813	cellular_component	centrosome
M	0005819	cellular_component	spindle
M	0005829	cellular_component	cytosol
M	0005876	cellular_component	spindle microtubule
M	0005886	cellular_component	plasma membrane
M	0007186	biological_process	G protein-coupled receptor signaling pathway
M	0008076	cellular_component	voltage-gated potassium channel complex
M	0010856	molecular_function	adenylate cyclase activator activity
M	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
M	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
M	0016020	cellular_component	membrane
M	0016240	biological_process	autophagosome membrane docking
M	0019855	molecular_function	calcium channel inhibitor activity
M	0019901	molecular_function	protein kinase binding
M	0021762	biological_process	substantia nigra development
M	0030017	cellular_component	sarcomere
M	0031432	molecular_function	titin binding
M	0031514	cellular_component	motile cilium
M	0031982	cellular_component	vesicle
M	0032465	biological_process	regulation of cytokinesis
M	0032991	cellular_component	protein-containing complex
M	0034704	cellular_component	calcium channel complex
M	0035458	biological_process	cellular response to interferon-beta
M	0043209	cellular_component	myelin sheath
M	0043539	molecular_function	protein serine/threonine kinase activator activity
M	0044305	cellular_component	calyx of Held
M	0044325	molecular_function	transmembrane transporter binding
M	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
M	0046872	molecular_function	metal ion binding
M	0048306	molecular_function	calcium-dependent protein binding
M	0051592	biological_process	response to calcium ion
M	0055117	biological_process	regulation of cardiac muscle contraction
M	0060291	biological_process	long-term synaptic potentiation
M	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
M	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
M	0071346	biological_process	cellular response to type II interferon
M	0072542	molecular_function	protein phosphatase activator activity
M	0097225	cellular_component	sperm midpiece
M	0097720	biological_process	calcineurin-mediated signaling
M	0098901	biological_process	regulation of cardiac muscle cell action potential
M	0099523	cellular_component	presynaptic cytosol
M	0140056	biological_process	organelle localization by membrane tethering
M	0140238	biological_process	presynaptic endocytosis
M	0141110	molecular_function	transporter inhibitor activity
M	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
M	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
M	1902494	cellular_component	catalytic complex
M	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
M	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
O	0000922	cellular_component	spindle pole
O	0002027	biological_process	regulation of heart rate
O	0005246	molecular_function	calcium channel regulator activity
O	0005509	molecular_function	calcium ion binding
O	0005513	biological_process	detection of calcium ion
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005813	cellular_component	centrosome
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0005876	cellular_component	spindle microtubule
O	0005886	cellular_component	plasma membrane
O	0007186	biological_process	G protein-coupled receptor signaling pathway
O	0008076	cellular_component	voltage-gated potassium channel complex
O	0010856	molecular_function	adenylate cyclase activator activity
O	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
O	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
O	0016020	cellular_component	membrane
O	0016240	biological_process	autophagosome membrane docking
O	0019855	molecular_function	calcium channel inhibitor activity
O	0019901	molecular_function	protein kinase binding
O	0021762	biological_process	substantia nigra development
O	0030017	cellular_component	sarcomere
O	0031432	molecular_function	titin binding
O	0031514	cellular_component	motile cilium
O	0031982	cellular_component	vesicle
O	0032465	biological_process	regulation of cytokinesis
O	0032991	cellular_component	protein-containing complex
O	0034704	cellular_component	calcium channel complex
O	0035458	biological_process	cellular response to interferon-beta
O	0043209	cellular_component	myelin sheath
O	0043539	molecular_function	protein serine/threonine kinase activator activity
O	0044305	cellular_component	calyx of Held
O	0044325	molecular_function	transmembrane transporter binding
O	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
O	0046872	molecular_function	metal ion binding
O	0048306	molecular_function	calcium-dependent protein binding
O	0051592	biological_process	response to calcium ion
O	0055117	biological_process	regulation of cardiac muscle contraction
O	0060291	biological_process	long-term synaptic potentiation
O	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
O	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
O	0071346	biological_process	cellular response to type II interferon
O	0072542	molecular_function	protein phosphatase activator activity
O	0097225	cellular_component	sperm midpiece
O	0097720	biological_process	calcineurin-mediated signaling
O	0098901	biological_process	regulation of cardiac muscle cell action potential
O	0099523	cellular_component	presynaptic cytosol
O	0140056	biological_process	organelle localization by membrane tethering
O	0140238	biological_process	presynaptic endocytosis
O	0141110	molecular_function	transporter inhibitor activity
O	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
O	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
O	1902494	cellular_component	catalytic complex
O	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
O	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
Q	0000922	cellular_component	spindle pole
Q	0002027	biological_process	regulation of heart rate
Q	0005246	molecular_function	calcium channel regulator activity
Q	0005509	molecular_function	calcium ion binding
Q	0005513	biological_process	detection of calcium ion
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005813	cellular_component	centrosome
Q	0005819	cellular_component	spindle
Q	0005829	cellular_component	cytosol
Q	0005876	cellular_component	spindle microtubule
Q	0005886	cellular_component	plasma membrane
Q	0007186	biological_process	G protein-coupled receptor signaling pathway
Q	0008076	cellular_component	voltage-gated potassium channel complex
Q	0010856	molecular_function	adenylate cyclase activator activity
Q	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Q	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Q	0016020	cellular_component	membrane
Q	0016240	biological_process	autophagosome membrane docking
Q	0019855	molecular_function	calcium channel inhibitor activity
Q	0019901	molecular_function	protein kinase binding
Q	0021762	biological_process	substantia nigra development
Q	0030017	cellular_component	sarcomere
Q	0031432	molecular_function	titin binding
Q	0031514	cellular_component	motile cilium
Q	0031982	cellular_component	vesicle
Q	0032465	biological_process	regulation of cytokinesis
Q	0032991	cellular_component	protein-containing complex
Q	0034704	cellular_component	calcium channel complex
Q	0035458	biological_process	cellular response to interferon-beta
Q	0043209	cellular_component	myelin sheath
Q	0043539	molecular_function	protein serine/threonine kinase activator activity
Q	0044305	cellular_component	calyx of Held
Q	0044325	molecular_function	transmembrane transporter binding
Q	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
Q	0046872	molecular_function	metal ion binding
Q	0048306	molecular_function	calcium-dependent protein binding
Q	0051592	biological_process	response to calcium ion
Q	0055117	biological_process	regulation of cardiac muscle contraction
Q	0060291	biological_process	long-term synaptic potentiation
Q	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
Q	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
Q	0071346	biological_process	cellular response to type II interferon
Q	0072542	molecular_function	protein phosphatase activator activity
Q	0097225	cellular_component	sperm midpiece
Q	0097720	biological_process	calcineurin-mediated signaling
Q	0098901	biological_process	regulation of cardiac muscle cell action potential
Q	0099523	cellular_component	presynaptic cytosol
Q	0140056	biological_process	organelle localization by membrane tethering
Q	0140238	biological_process	presynaptic endocytosis
Q	0141110	molecular_function	transporter inhibitor activity
Q	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
Q	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
Q	1902494	cellular_component	catalytic complex
Q	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
Q	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
S	0000922	cellular_component	spindle pole
S	0002027	biological_process	regulation of heart rate
S	0005246	molecular_function	calcium channel regulator activity
S	0005509	molecular_function	calcium ion binding
S	0005513	biological_process	detection of calcium ion
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005819	cellular_component	spindle
S	0005829	cellular_component	cytosol
S	0005876	cellular_component	spindle microtubule
S	0005886	cellular_component	plasma membrane
S	0007186	biological_process	G protein-coupled receptor signaling pathway
S	0008076	cellular_component	voltage-gated potassium channel complex
S	0010856	molecular_function	adenylate cyclase activator activity
S	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
S	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
S	0016020	cellular_component	membrane
S	0016240	biological_process	autophagosome membrane docking
S	0019855	molecular_function	calcium channel inhibitor activity
S	0019901	molecular_function	protein kinase binding
S	0021762	biological_process	substantia nigra development
S	0030017	cellular_component	sarcomere
S	0031432	molecular_function	titin binding
S	0031514	cellular_component	motile cilium
S	0031982	cellular_component	vesicle
S	0032465	biological_process	regulation of cytokinesis
S	0032991	cellular_component	protein-containing complex
S	0034704	cellular_component	calcium channel complex
S	0035458	biological_process	cellular response to interferon-beta
S	0043209	cellular_component	myelin sheath
S	0043539	molecular_function	protein serine/threonine kinase activator activity
S	0044305	cellular_component	calyx of Held
S	0044325	molecular_function	transmembrane transporter binding
S	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
S	0046872	molecular_function	metal ion binding
S	0048306	molecular_function	calcium-dependent protein binding
S	0051592	biological_process	response to calcium ion
S	0055117	biological_process	regulation of cardiac muscle contraction
S	0060291	biological_process	long-term synaptic potentiation
S	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
S	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
S	0071346	biological_process	cellular response to type II interferon
S	0072542	molecular_function	protein phosphatase activator activity
S	0097225	cellular_component	sperm midpiece
S	0097720	biological_process	calcineurin-mediated signaling
S	0098901	biological_process	regulation of cardiac muscle cell action potential
S	0099523	cellular_component	presynaptic cytosol
S	0140056	biological_process	organelle localization by membrane tethering
S	0140238	biological_process	presynaptic endocytosis
S	0141110	molecular_function	transporter inhibitor activity
S	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
S	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
S	1902494	cellular_component	catalytic complex
S	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
S	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA A 501

Chain	Residue
A	ASP20
A	ASP22
A	ASP24
A	THR26
A	GLU31

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CA A 502

Chain	Residue
A	ASP56
A	ASN60
A	THR62
A	GLU67

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 503

Chain	Residue
A	ASP93
A	ASP95
A	ASN97
A	TYR99
A	GLU104
A	HOH603

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CA C 501

Chain	Residue
C	ASP20
C	ASP22
C	ASP24
C	THR26
C	GLU31

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CA C 502

Chain	Residue
C	ASP56
C	ASP58
C	ASN60
C	THR62
C	GLU67

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CA C 503

Chain	Residue
C	ASP93
C	ASP95
C	ASN97
C	TYR99
C	GLU104

---

site_id	AC7
Number of Residues	5
Details	binding site for residue CA E 501

Chain	Residue
E	ASP20
E	ASP22
E	ASP24
E	THR26
E	GLU31

---

site_id	AC8
Number of Residues	7
Details	binding site for residue CA E 502

Chain	Residue
E	ASP56
E	ASP58
E	ASN60
E	THR62
E	GLU67
E	HOH601
E	HOH602

---

site_id	AC9
Number of Residues	5
Details	binding site for residue CA E 503

Chain	Residue
E	ASP93
E	ASP95
E	ASN97
E	TYR99
E	GLU104

---

site_id	AD1
Number of Residues	5
Details	binding site for residue CA G 501

Chain	Residue
G	ASP20
G	ASP22
G	ASP24
G	THR26
G	GLU31

---

site_id	AD2
Number of Residues	6
Details	binding site for residue CA G 502

Chain	Residue
G	ASP56
G	ASP58
G	ASN60
G	THR62
G	GLU67
G	HOH601

---

site_id	AD3
Number of Residues	5
Details	binding site for residue CA G 503

Chain	Residue
G	ASP93
G	ASP95
G	ASN97
G	TYR99
G	GLU104

---

site_id	AD4
Number of Residues	5
Details	binding site for residue CA I 501

Chain	Residue
I	ASP20
I	ASP22
I	ASP24
I	THR26
I	GLU31

---

site_id	AD5
Number of Residues	6
Details	binding site for residue CA I 502

Chain	Residue
I	ASP56
I	ASP58
I	ASN60
I	THR62
I	GLU67
I	HOH603

---

site_id	AD6
Number of Residues	6
Details	binding site for residue CA K 501

Chain	Residue
K	ASP20
K	ASP22
K	ASP24
K	THR26
K	GLU31
K	HOH602

---

site_id	AD7
Number of Residues	5
Details	binding site for residue CA K 502

Chain	Residue
K	ASP56
K	ASP58
K	ASN60
K	THR62
K	GLU67

---

site_id	AD8
Number of Residues	5
Details	binding site for residue CA K 503

Chain	Residue
K	ASP93
K	ASP95
K	ASN97
K	TYR99
K	GLU104

---

site_id	AD9
Number of Residues	5
Details	binding site for residue CA M 501

Chain	Residue
M	ASP20
M	ASP22
M	ASP24
M	THR26
M	GLU31

---

site_id	AE1
Number of Residues	6
Details	binding site for residue CA M 502

Chain	Residue
M	GLU67
M	HOH601
M	ASP56
M	ASP58
M	ASN60
M	THR62

---

site_id	AE2
Number of Residues	6
Details	binding site for residue CA M 503

Chain	Residue
M	ASP93
M	ASP95
M	ASN97
M	TYR99
M	GLU104
M	HOH602

---

site_id	AE3
Number of Residues	5
Details	binding site for residue CA O 501

Chain	Residue
O	ASP20
O	ASP22
O	ASP24
O	THR26
O	GLU31

---

site_id	AE4
Number of Residues	5
Details	binding site for residue CA O 502

Chain	Residue
O	ASP56
O	ASP58
O	ASN60
O	THR62
O	GLU67

---

site_id	AE5
Number of Residues	5
Details	binding site for residue CA O 503

Chain	Residue
O	ASP93
O	ASP95
O	ASN97
O	TYR99
O	GLU104

---

site_id	AE6
Number of Residues	5
Details	binding site for residue CA Q 501

Chain	Residue
Q	ASP20
Q	ASP22
Q	ASP24
Q	THR26
Q	GLU31

---

site_id	AE7
Number of Residues	6
Details	binding site for residue CA Q 502

Chain	Residue
Q	ASP56
Q	ASP58
Q	ASN60
Q	THR62
Q	GLU67
Q	HOH601

---

site_id	AE8
Number of Residues	5
Details	binding site for residue CA Q 503

Chain	Residue
Q	ASP93
Q	ASP95
Q	ASN97
Q	TYR99
Q	GLU104

---

site_id	AE9
Number of Residues	5
Details	binding site for residue CA S 501

Chain	Residue
S	ASP20
S	ASP22
S	ASP24
S	THR26
S	GLU31

---

site_id	AF1
Number of Residues	6
Details	binding site for residue CA S 502

Chain	Residue
S	ASP56
S	ASP58
S	ASN60
S	THR62
S	ASP64
S	GLU67

---

site_id	AF2
Number of Residues	5
Details	binding site for residue CA S 503

Chain	Residue
S	ASP93
S	ASP95
S	ASN97
S	TYR99
S	GLU104

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
A	ASP20-LEU32
A	ASP56-PHE68
A	ASP93-LEU105

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	350
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	100
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25441029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V0C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29724949","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CNO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	9
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	10
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	20
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	32
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	9
Details	Modified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP29","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	20
Details	Region: {"description":"Calmodulin-binding IQ region","evidences":[{"source":"PubMed","id":"16299511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16338416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19279214","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20953164","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---